Steroid ligands bind human sex hormone-binding globulin in specific orientations and produce distinct changes in protein conformation

Journal of Biological Chemistry

Volumn 277, Issue 35, 2002, Pages 32086-32093

  Grishkovskaya, Irina ^a,b,c,d   Avvakumov, George V ^a,b,c,d   Hammond, Geoffrey L ^a,b,c,d   Catalano, Maria G ^a,b,c,d   Muller, Yves A ^a,b,c,d  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

^d UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; CRYSTAL STRUCTURE; HORMONES; HYDROGEN BONDS; MACROMOLECULES; METABOLITES; PROTEINS;

LIGANDS;

BIOCHEMISTRY;

3BETA ANDROSTANEDIOL; 5ALPHA ANDROSTAN 3BETA,17ALPHA DIOL; ANDROSTANEDIOL; ANDROSTANOLONE; ESTRADIOL; LAMININ; LEVONORGESTREL; LIGAND; PROGESTERONE DERIVATIVE; SERINE; SEX HORMONE BINDING GLOBULIN; STEROID; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; HYDROGEN BOND; LIGAND BINDING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE; STEROID BINDING;

AMINO ACID SUBSTITUTION; BASE SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DNA PRIMERS; HUMANS; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; SEX HORMONE-BINDING GLOBULIN; STEROIDS; SUBSTRATE SPECIFICITY; VARIATION (GENETICS);

EID: 0037200050     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M203999200     Document Type: Article

References (35)