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Volumn 2, Issue 4, 2001, Pages 318-323

Stem Cell Grafting for Epilepsy: Clinical Promise and Ethical Concerns

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EID: 0346611137     PISSN: 15255050     EISSN: None     Source Type: Journal    
DOI: 10.1006/ebeh.2001.0230     Document Type: Review
Times cited : (4)

References (54)
  • 1
    • 0021988433 scopus 로고
    • Transplantation of adrenal medullary tissue to striatum in parkinsonism: First clinical trials
    • Backlund EO, Granberg PO, Hamberger B, et al. Transplantation of adrenal medullary tissue to striatum in parkinsonism: first clinical trials. J Neurosurg 1985;62:169-73.
    • (1985) J Neurosurg , vol.62 , pp. 169-173
    • Backlund, E.O.1    Granberg, P.O.2    Hamberger, B.3
  • 3
    • 0031938976 scopus 로고    scopus 로고
    • Primary neural precursors and intermitotic nuclear migration in the ventricular zone of adult canaries
    • Alvarez-Buylla A, Garcia-Verdugo JM, Mateo A, Merchant-Larios H. Primary neural precursors and intermitotic nuclear migration in the ventricular zone of adult canaries. J Neurosci 1998;18:1020-37.
    • (1998) J Neurosci , vol.18 , pp. 1020-1037
    • Alvarez-Buylla, A.1    Garcia-Verdugo, J.M.2    Mateo, A.3    Merchant-Larios, H.4
  • 4
    • 0034712047 scopus 로고    scopus 로고
    • Mammalian neural stem cells
    • Gage FH. Mammalian neural stem cells. Science 2000;287: 1433-8.
    • (2000) Science , vol.287 , pp. 1433-1438
    • Gage, F.H.1
  • 5
    • 0034057219 scopus 로고    scopus 로고
    • Characterization of the subventricular zone of the adult human brain: Evidence for the involvement of Bcl-2
    • Bernier PJ, Vinet J, Cossette M, Parent A. Characterization of the subventricular zone of the adult human brain: evidence for the involvement of Bcl-2. Neurosci Res 2000;37:67-78.
    • (2000) Neurosci Res , vol.37 , pp. 67-78
    • Bernier, P.J.1    Vinet, J.2    Cossette, M.3    Parent, A.4
  • 6
    • 0033987675 scopus 로고    scopus 로고
    • Enhancement of progenitor cell division in the dentate gyrus triggered by initial limbic seizures in rat models of epilepsy
    • Nakagawa E, Aimi Y, Yasuhara O, Tooyama I, Shimada M, McGeer PL, Kimura H. Enhancement of progenitor cell division in the dentate gyrus triggered by initial limbic seizures in rat models of epilepsy. Epilepsia 2000;41:10-8.
    • (2000) Epilepsia , vol.41 , pp. 10-18
    • Nakagawa, E.1    Aimi, Y.2    Yasuhara, O.3    Tooyama, I.4    Shimada, M.5    McGeer, P.L.6    Kimura, H.7
  • 7
    • 0034663012 scopus 로고    scopus 로고
    • Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: Functional implications of seizure-induced neurogenesis
    • Scharfman HE, Goodman JH, Sollas AL. Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: functional implications of seizure-induced neurogenesis. J Neurosci 2000;20:6144-58.
    • (2000) J Neurosci , vol.20 , pp. 6144-6158
    • Scharfman, H.E.1    Goodman, J.H.2    Sollas, A.L.3
  • 8
    • 0034007074 scopus 로고    scopus 로고
    • Hippocampal stem cells differentiate into excitatory and inhibitory neurons
    • Vicario-Abejon C, Collin C, Tsoulfas P, McKay RD. Hippocampal stem cells differentiate into excitatory and inhibitory neurons. Eur J Neurosci 2000;12:677-88.
    • (2000) Eur J Neurosci , vol.12 , pp. 677-688
    • Vicario-Abejon, C.1    Collin, C.2    Tsoulfas, P.3    McKay, R.D.4
  • 9
    • 2642702860 scopus 로고    scopus 로고
    • Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra
    • Loscher W, Ebert U, Lehmann H, Rosenthal C, Nikkhah G. Seizure suppression in kindling epilepsy by grafts of fetal GABAergic neurons in rat substantia nigra. J Neurosci Res 1998;51:196-209.
    • (1998) J Neurosci Res , vol.51 , pp. 196-209
    • Loscher, W.1    Ebert, U.2    Lehmann, H.3    Rosenthal, C.4    Nikkhah, G.5
  • 10
    • 0002059790 scopus 로고    scopus 로고
    • Porcine fetal GABA-producing neural cell transplants for human partial-onset seizures: Safety and feasibility
    • Schachter SC, Schomer DL, Blume H, Ives JR, Joseph J, Vonsattel JP, Dinsmore J. Porcine fetal GABA-producing neural cell transplants for human partial-onset seizures: safety and feasibility. Epilepsia 1998;39(suppl 6):67.
    • (1998) Epilepsia , vol.39 , Issue.6 SUPPL. , pp. 67
    • Schachter, S.C.1    Schomer, D.L.2    Blume, H.3    Ives, J.R.4    Joseph, J.5    Vonsattel, J.P.6    Dinsmore, J.7
  • 11
    • 85031468963 scopus 로고    scopus 로고
    • Porcine embryonic GABAergic cell transplants
    • Bialer M, Johannessen SI, Kupferberg HJ, Levy RH, Loiseau P, Perucca E, editors. Conference review: progress report on new antiepileptic drugs. A summary of the 5th Eilat Conference
    • Schachter SC. Porcine embryonic GABAergic cell transplants. In: Bialer M, Johannessen SI, Kupferberg HJ, Levy RH, Loiseau P, Perucca E, editors. Conference review: progress report on new antiepileptic drugs. A summary of the 5th Eilat Conference. Epilepsy Res 2001;43:32.
    • (2001) Epilepsy Res , vol.43 , pp. 32
    • Schachter, S.C.1
  • 12
    • 0033564219 scopus 로고    scopus 로고
    • Long-term survival of fetal porcine lateral ganglionic eminence cells in the hippocampus of rats
    • Jacoby DB, Lindberg C, Cunningham MG, Ratliff J, Dinsmore J. Long-term survival of fetal porcine lateral ganglionic eminence cells in the hippocampus of rats. J Neurosci Res 1999;56: 581-94.
    • (1999) J Neurosci Res , vol.56 , pp. 581-594
    • Jacoby, D.B.1    Lindberg, C.2    Cunningham, M.G.3    Ratliff, J.4    Dinsmore, J.5
  • 13
    • 1842369693 scopus 로고    scopus 로고
    • Long term improvement in patients with severe Parkinson's disease after implantation of fetal ventral mesencephalic tissue in a cavity of the caudate nucleus: 5 year follow-up in 10 patients
    • Lopez-Lozano JJ, Bravo G, Brera B, Millan I, Dargallo J, Salmean J. Long term improvement in patients with severe Parkinson's disease after implantation of fetal ventral mesencephalic tissue in a cavity of the caudate nucleus: 5 year follow-up in 10 patients. J Neurosurg 1997;86:931-42.
    • (1997) J Neurosurg , vol.86 , pp. 931-942
    • Lopez-Lozano, J.J.1    Bravo, G.2    Brera, B.3    Millan, I.4    Dargallo, J.5    Salmean, J.6
  • 14
    • 0034051525 scopus 로고    scopus 로고
    • Intrastriatal and intranigral grafting of hNT neurons in the 6-OHDA rat model of Parkinson's disease
    • Baker KA, Hong M, Sadi D, Mendez I. Intrastriatal and intranigral grafting of hNT neurons in the 6-OHDA rat model of Parkinson's disease. Exp Neurol 2000;162:350-60.
    • (2000) Exp Neurol , vol.162 , pp. 350-360
    • Baker, K.A.1    Hong, M.2    Sadi, D.3    Mendez, I.4
  • 15
    • 0033955716 scopus 로고    scopus 로고
    • Differential response of ventral midbrain and striatal progenitor cells to lesions of the nigrostriatal dopaminergic projection
    • Kay JN, Blum M. Differential response of ventral midbrain and striatal progenitor cells to lesions of the nigrostriatal dopaminergic projection. Dev Neurosci 2000;22:56-67.
    • (2000) Dev Neurosci , vol.22 , pp. 56-67
    • Kay, J.N.1    Blum, M.2
  • 16
    • 33644684826 scopus 로고    scopus 로고
    • Transplantation of expanded mesencephalic precursors leads to recovery in Parkinsonian rats
    • Studer L, Tabar V, McKay RD. Transplantation of expanded mesencephalic precursors leads to recovery in Parkinsonian rats. Nat Neurosci 1998;1:290-5.
    • (1998) Nat Neurosci , vol.1 , pp. 290-295
    • Studer, L.1    Tabar, V.2    McKay, R.D.3
  • 17
    • 0035826089 scopus 로고    scopus 로고
    • Transplantation of embryonic dopamine neurons for severe Parkinson's disease
    • Freed C, Greene PE, Breeze RE, et al. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med 2001;344:710-9.
    • (2001) N Engl J Med , vol.344 , pp. 710-719
    • Freed, C.1    Greene, P.E.2    Breeze, R.E.3
  • 18
    • 0032858203 scopus 로고    scopus 로고
    • Differentiation and angiogenesis of central nervous system stem cells implanted with mesenchyme into ischemic rat brain
    • Fukunaga A, Uchida K, Hara K, Kuroshima Y, Kawase T. Differentiation and angiogenesis of central nervous system stem cells implanted with mesenchyme into ischemic rat brain. Cell Transplant 1999;8:435-41.
    • (1999) Cell Transplant , vol.8 , pp. 435-441
    • Fukunaga, A.1    Uchida, K.2    Hara, K.3    Kuroshima, Y.4    Kawase, T.5
  • 19
    • 0033845975 scopus 로고    scopus 로고
    • Transplantation of cultured human neuronal cells for patients with stroke
    • Kondziolka D, Wechsler L, Goldstein S, et al. Transplantation of cultured human neuronal cells for patients with stroke. Neurology 2000;55:565-9.
    • (2000) Neurology , vol.55 , pp. 565-569
    • Kondziolka, D.1    Wechsler, L.2    Goldstein, S.3
  • 20
    • 0032759046 scopus 로고    scopus 로고
    • Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord
    • McDonald JW, Liu XZ, Qu Y, et al. Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat Med 1999;5:1410-2.
    • (1999) Nat Med , vol.5 , pp. 1410-1412
    • McDonald, J.W.1    Liu, X.Z.2    Qu, Y.3
  • 21
    • 0033757632 scopus 로고    scopus 로고
    • Functional recovery of paraplegic rats and motor axon regeneration in spinal cord by olfactory ensheathing glia
    • Ramon Cueto A, Cordero MI, Santos-Benito FF, Avila J. Functional recovery of paraplegic rats and motor axon regeneration in spinal cord by olfactory ensheathing glia. Neuron 2000;25: 425-35.
    • (2000) Neuron , vol.25 , pp. 425-435
    • Ramon Cueto, A.1    Cordero, M.I.2    Santos-Benito, F.F.3    Avila, J.4
  • 22
    • 0032818773 scopus 로고    scopus 로고
    • Intraspinal delivery of neurotrophin-3 using neural stem cells genetically modified by recombinant retrovirus
    • Liu Y, Himes BT, Solowska J, et al. Intraspinal delivery of neurotrophin-3 using neural stem cells genetically modified by recombinant retrovirus. Exp Neurol 1999;158:9-26.
    • (1999) Exp Neurol , vol.158 , pp. 9-26
    • Liu, Y.1    Himes, B.T.2    Solowska, J.3
  • 23
    • 0033618593 scopus 로고    scopus 로고
    • Embryonic stem cell-derived glial precursors: A source of myelinating transplants
    • Brustle O, Jones KN, Learish RD, et al. Embryonic stem cell-derived glial precursors: a source of myelinating transplants. Science 1999;285:754-6.
    • (1999) Science , vol.285 , pp. 754-756
    • Brustle, O.1    Jones, K.N.2    Learish, R.D.3
  • 24
    • 0033935379 scopus 로고    scopus 로고
    • Survival, neuronal differentiation, and fiber outgrowth of propagated human neural precursor grafts in an animal model of Huntington's disease
    • Armstrong RJ, Watts C, Svendsen CN, Dunnett SB, Rosser ARE. Survival, neuronal differentiation, and fiber outgrowth of propagated human neural precursor grafts in an animal model of Huntington's disease. Cell Transplant 2000;9:55-64.
    • (2000) Cell Transplant , vol.9 , pp. 55-64
    • Armstrong, R.J.1    Watts, C.2    Svendsen, C.N.3    Dunnett, S.B.4    Rosser, A.R.E.5
  • 25
    • 0030885063 scopus 로고    scopus 로고
    • Grafts of EGF-responsive neural stem cells derived from GFAP-hNGF transgenic mice: Trophic and tropic effects in a rodent model of Huntington's disease
    • Kordower JH, Chen EY, Winkler C, et al. Grafts of EGF-responsive neural stem cells derived from GFAP-hNGF transgenic mice: trophic and tropic effects in a rodent model of Huntington's disease. J Comp Neurol 1997;387:96-113.
    • (1997) J Comp Neurol , vol.387 , pp. 96-113
    • Kordower, J.H.1    Chen, E.Y.2    Winkler, C.3
  • 26
    • 0033919344 scopus 로고    scopus 로고
    • The human pluripotent stem cell: Impact on medicine and society
    • Edwards BE, Gearhart JD, Wallach EE. The human pluripotent stem cell: impact on medicine and society. Fertil Steril 2000;74: 1-7.
    • (2000) Fertil Steril , vol.74 , pp. 1-7
    • Edwards, B.E.1    Gearhart, J.D.2    Wallach, E.E.3
  • 27
    • 0034612168 scopus 로고    scopus 로고
    • The politics and ethics of human embryo and stem cell research
    • Ryan KJ. The politics and ethics of human embryo and stem cell research. Womens Health Issues 2000;10:105-10.
    • (2000) Womens Health Issues , vol.10 , pp. 105-110
    • Ryan, K.J.1
  • 28
    • 0342614901 scopus 로고    scopus 로고
    • A time for restraint
    • Young FE. A time for restraint. Science 2000;287:1424.
    • (2000) Science , vol.287 , pp. 1424
    • Young, F.E.1
  • 29
    • 0034116497 scopus 로고    scopus 로고
    • Human embryonic stem cells and respect for life
    • Meyer JR. Human embryonic stem cells and respect for life. J Med Ethics 2000;26:166-70.
    • (2000) J Med Ethics , vol.26 , pp. 166-170
    • Meyer, J.R.1
  • 30
    • 0030894092 scopus 로고    scopus 로고
    • Stem cells in the central nervous system
    • McKay R. Stem cells in the central nervous system. Science 1997;276:66-71.
    • (1997) Science , vol.276 , pp. 66-71
    • McKay, R.1
  • 31
    • 0002880481 scopus 로고    scopus 로고
    • Health-care delivery and resource allocation
    • Veatch RM, editor. Boston: Jones & Bartlett
    • Buchanan A. Health-care delivery and resource allocation. In: Veatch RM, editor. Medical ethics. 2nd ed. Boston: Jones & Bartlett, 1997:321-62.
    • (1997) Medical Ethics. 2nd Ed. , pp. 321-362
    • Buchanan, A.1
  • 32
    • 0006040046 scopus 로고    scopus 로고
    • Ethical aspects of gene therapy: A clinical perspective
    • Fundación BBV, editor. Bilbao: Fundación BBV
    • Grisolía JS. Ethical aspects of gene therapy: a clinical perspective. In: Fundación BBV, editor. Gene therapy. Bilbao: Fundación BBV, 1999:67-82.
    • (1999) Gene Therapy , pp. 67-82
    • Grisolía, J.S.1
  • 33
    • 0031106282 scopus 로고    scopus 로고
    • The ethics of human genetic intervention: A post-modern perspective
    • Dyer AR. The ethics of human genetic intervention: a post-modern perspective. Exp Neurol 1997;144:168-72.
    • (1997) Exp Neurol , vol.144 , pp. 168-172
    • Dyer, A.R.1
  • 34
    • 0001874760 scopus 로고    scopus 로고
    • Informed consent
    • Veatch RM, editor. Boston: Jones & Bartlett
    • Beauchamp TL. Informed consent. In: Veatch RM, editor. Medical ethics. 2nd ed. Boston: Jones & Bartlett, 1997:185-209.
    • (1997) Medical Ethics. 2nd Ed. , pp. 185-209
    • Beauchamp, T.L.1
  • 35
    • 0029890418 scopus 로고    scopus 로고
    • Do brain transplants alter personal identity? Inadequacies of some "standard" arguments
    • Northoff G. Do brain transplants alter personal identity? Inadequacies of some "standard" arguments. J Med Ethics 1996;22: 174-80.
    • (1996) J Med Ethics , vol.22 , pp. 174-180
    • Northoff, G.1
  • 36
    • 0034027481 scopus 로고    scopus 로고
    • Relationship of lesion location to cognitive outcome following microelectrode-guided pallidotomy for Parkinson's disease: Support for the existence of cognitive circuits in the human pallidum
    • Lombardi WJ, Gross RE, Trepanier LL, Lang AE, Lozano AM, Saint-Cyr JA. Relationship of lesion location to cognitive outcome following microelectrode-guided pallidotomy for Parkinson's disease: support for the existence of cognitive circuits in the human pallidum. Brain 2000;123:746-58.
    • (2000) Brain , vol.123 , pp. 746-758
    • Lombardi, W.J.1    Gross, R.E.2    Trepanier, L.L.3    Lang, A.E.4    Lozano, A.M.5    Saint-Cyr, J.A.6
  • 37
    • 0029809914 scopus 로고    scopus 로고
    • Empirical techniques for determining reliability, magnitude and pattern of neuropsychological change after epilepsy surgery
    • Hermann BP, Seidenberg M, Schoenfeld J, Peterson J, Leveron C, Wyler AR. Empirical techniques for determining reliability, magnitude and pattern of neuropsychological change after epilepsy surgery. Epilepsia 1996;37:942-50.
    • (1996) Epilepsia , vol.37 , pp. 942-950
    • Hermann, B.P.1    Seidenberg, M.2    Schoenfeld, J.3    Peterson, J.4    Leveron, C.5    Wyler, A.R.6
  • 38
    • 0027093541 scopus 로고
    • Psychosurgery in the modern era: Therapeutic and ethical aspects
    • Rappaport ZH. Psychosurgery in the modern era: therapeutic and ethical aspects. Med Law 1992;11:449-53.
    • (1992) Med Law , vol.11 , pp. 449-453
    • Rappaport, Z.H.1
  • 40
  • 41
  • 45
    • 0006040047 scopus 로고
    • The human search for meaning
    • Fundación BBV, editor. Bilbao: Fundación BBV
    • Grisolía JS. The human search for meaning. In: Fundación BBV, editor. Human Genome Project: ethics. Bilbao: Fundación BBV, 1990:183-200.
    • (1990) Human Genome Project: Ethics , pp. 183-200
    • Grisolía, J.S.1
  • 47
    • 0034277857 scopus 로고    scopus 로고
    • On the sanctity of nature
    • Kaebnick GE. On the sanctity of nature. Hastings Center Rep 2000;30(5):16-23.
    • (2000) Hastings Center Rep , vol.30 , Issue.5 , pp. 16-23
    • Kaebnick, G.E.1
  • 48
    • 84935432409 scopus 로고
    • The Human Genome Project and our sense of self
    • Grisolía JS. The Human Genome Project and our sense of self. Impact Sci Soc 1991;41:45-8.
    • (1991) Impact Sci Soc , vol.41 , pp. 45-48
    • Grisolía, J.S.1
  • 49
    • 0024413030 scopus 로고
    • Genes and dreams
    • Grisolía JS. Genes and dreams. West J Med 1989;151:564-6.
    • (1989) West J Med , vol.151 , pp. 564-566
    • Grisolía, J.S.1
  • 52
    • 0006041980 scopus 로고    scopus 로고
    • Narrative in medical ethics
    • Jones AH. Narrative in medical ethics. WJM 1999;171:50-2.
    • (1999) WJM , vol.171 , pp. 50-52
    • Jones, A.H.1


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