Renal abnormalities in rat fetuses exposed to doxorubicin

Journal of Urology

Volumn 171, Issue 2 I, 2004, Pages 877-881

  Temelcos, Catherine ^a   Hutson, John M ^a,b  

^a MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

Bladder; Doxorubicin; Fetus; Kidney; Rats, Sprague Dawley

Indexed keywords

DOXORUBICIN;

AGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER; CONTROLLED STUDY; FEMALE; FETUS; FETUS MALFORMATION; HISTOLOGY; HISTOPATHOLOGY; HYDRONEPHROSIS; KIDNEY MALFORMATION; KIDNEY MASS; KIDNEY SIZE; NONHUMAN; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RAT; URETER;

EID: 0346499029     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000105068.37019.e7     Document Type: Article

References (20)

1. Thompson, D. J., Molello, J. A., Strebing, R. J. and Dyke, I. L.: Teratogenicity of adriamycin and daunomycin in the rat and rabbit. Teratology, 17: 151, 1978
2. Quan, L. and Smith, D. W.: The VATER association: vertebral defects, anal atresia, T-E fistula with esophageal atresia, radial and renal dysplasia: a spectrum of associated defects. J Pediatr, 82: 104, 1973
3. Chevalier, R. L.: Molecular and cellular pathophysiology of obstructive nephropathy. Pediatr Nephrol, 13: 612, 1999
4. Peters, C. A.: Obstruction of the fetal urinary tract. J Am Soc Nephrol, 8: 653, 1997
5. Thomasson, B. H., Esterly, J. R. and Ravitch, M. M.: Morphologic changes in the fetal rabbit kidney after intrauterine ureteral ligation. Invest Urol, 8: 261, 1970
6. Liu, M. I. and Hutson, J. M.: Cloacal and urogenital malformations in adriamycin-exposed rat fetuses. BJU Int, 86: 107, 2000
7. Merei, J., Hasthorpe, S., Farmer, P. and Hutson, J. M.: Visceral anomalies in prenatally adriamycin-exposed rat fetuses: a model for the VATER association. Pediatr Surg Int, 15: 11, 1999
8. Penington, E. C.: Anorectal and urogenital embryology. Clues from comparative embryology. Thesis, University of Melbourne, Melbourne, Victoria, Australia, 2001
9. Weaver, D. D., Mapstone, C. L. and Yu, P. L.: The VATER association. Analysis of 46 patients. Am J Dis Child, 140: 225, 1986
10. Orford, J. E. and Cass, D. T.: Dose response relationship between adriamycin and birth defects in a rat model of VATER association. J Pediatr Surg, 34: 392, 1999
11. Gulmi, F. A., Felsen, D. and Vaughan, E. D., Jr.: Pathophysiology of urinary tract obstruction. In: Campbell's Urology, 7th ed. Edited by P. C. Walsh, A. B. Retik, E. D. Vaughan, Jr. and A. J. Wein. Philadelphia: W. B. Saunders Co., vol. 1, chapt. 3, pp. 342-385, 1998
12. Beck, A. D.: The effect of intra-uterine urinary obstruction upon the development of the fetal kidney. J Urol, 105: 784, 1971
13. Kuure, S., Vuolteenaho, R. and Vainio, S.: Kidney morphogenesis: cellular and molecular regulation. Mech Dev, 92: 31, 2000
14. Lipschutz, J. H.: Molecular development of the kidney: a review of the results of gene disruption studies. Am J Kidney Dis, 31: 383, 1998
15. Matsell, D. G.: Renal dysplasia: new approaches to an old problem. Am J Kidney Dis, 32: 535, 1998
16. Woolf, A. S.: Emerging roles of obstruction and mutations in renal malformations. Pediatr Nephrol, 12: 690, 1998
17. Giavini, E., Lemonica, I. P., Lou, Y., Broccia, M. L. and Prati, M.: Induction of micronuclei and toxic effects in embryos of pregnant rats treated before implantation with anticancer drugs: cyclophosphamide, cis-platinum, adriamycin. Teratogen Carcinogen Mutagen, 10: 417, 1990
18. Glackin, C. A., Murray, E. J. and Murray, S. S.: Doxorubicin inhibits differentiation and enhances expression of the helix-loop-helix genes Id and mTwi in mouse osteoblastic cells. Biochem Int, 28: 67, 1992
19. Nishimura, H., Yerkes, E., Hohenfellner, K., Miyazaki, Y., Ma, J., Hunley, T. et al: Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Mol Cell, 3: 1, 1999
20. Chevalier, R. L. and Klahr, S.: Therapeutic approaches in obstructive uropathy. Semin Nephrol, 18: 652, 1998