Efficient Route to 1,3-Di-N-imidazolylbenzene. A Comparison of Monodentate vs Bidentate Carbenes in Pd-Catalyzed Cross Coupling

Organic Letters

Volumn 5, Issue 25, 2003, Pages 4847-4849

  Vargas, Victor C ^a   Rubio, Ramel J ^a   Hollis, T Keith ^a   Salcido, Martha E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DI N IMIDAZOLYLBENZENE; BENZENE DERIVATIVE; BENZENEBORONIC ACID; CARBENOID; CHLOROBENZENE; HALIDE; LIGAND; PALLADIUM; PALLADIUM COMPLEX; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CATALYST; CROSS COUPLING REACTION; METHODOLOGY; SUZUKI REACTION; SYNTHESIS;

EID: 0346422361     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol035906z     Document Type: Article

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31. 4, 391.1923).
32. 4, 301.1453).
33. 3 (2.0 mmol). Imidazolium salt with a 2:1 carbene: palladium ratio: 2, 6.0 mol %; 3, 3.0 mol %; 4, 3.0 mol %; 5, 3.0 mol %; 6, 3.0 mol %. Imidazolium salt with a 1:1 carbene:Pd ratio: 2, 3.0 mol %; 3, 1.5 mol %; 4, 1. 5 mol %; 5, 1.5 mol %; 6, 1.5 mol %. The vial was placed in an 80°C heating block and stirred for 2 h. An aliquot was analyzed by GC.
34. 2 (1.5 mmol) was then added. The vial was then heated to 80°C and stirred for 2 h. An aliquot was analyzed by GC.