α-Inhibin Immunoreactivity in Soft-Tissue Neoplasia

Modern Pathology

Volumn 16, Issue 12, 2003, Pages 1205-1209

  Schraith, Daniel F ^a,c   Hahm, Geoffrey K ^b,d   Niemann, Theodore H ^b,e   DeYoung, Barry R ^a  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c GUNDERSEN LUTHERAN MEDICAL CENTER   (United States)

^d WRIGHT PATTERSON AIR FORCE BASE   (United States)

^e St Anne's Hospital   (United States)

Author keywords

Immunohistochemistry; Inhibin; Soft tissue neoplasms

Indexed keywords

ALPHA INHIBIN; ALPHA INHIBIN ANTIBODY; ANTIBODY; AVIDIN; BIOTIN; EPITOPE; FORMALDEHYDE; INHIBIN; PARAFFIN; UNCLASSIFIED DRUG;

ADRENAL CORTEX; ANGIOSARCOMA; ARTICLE; DIFFERENTIAL DIAGNOSIS; HEMANGIOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIPOMA; LIPOSARCOMA; MAJOR CLINICAL STUDY; NEURILEMOMA; PRIORITY JOURNAL; RETROPERITONEAL TUMOR; RHABDOMYOMA; SEX CORD TUMOR; SOFT TISSUE TUMOR; STAINING;

HUMANS; IMMUNOHISTOCHEMISTRY; INHIBINS; NEOPLASMS, CONNECTIVE AND SOFT TISSUE;

EID: 0346362403     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.MP.0000095647.58306.DB     Document Type: Article

References (29)

1. Cuevas P, Ying S-Y, Ling N, Uneo N, Esch F, Guillemin R. Immunohistochemical detection of inhibin in the gonad. Biochem Biophys Res Commun 1987;142:23-30.
2. Vale W, Rivier C, Hsueh A, Campen C, Meunier H, Bicsak T, et al. Chemical and biological characterization of the inhibin family of protein hormones. Recent Prog Horm Res 1988;44: 1-34.
3. Kingsley D. The TGF-B superfamily; new members, new receptors, and new genetic tests of function in different organisms. Genes Dev 1994;8:133-46.
4. Vannelli GB, Barni T, Forti G, Negro-Vilar A, Vale W, Serio M, et al. Immunolocalization of inhibin alpha-subunit in the human testis. A light- and electron-microscopy study. Cell Tissue Res 1992;269:221-7.
5. Zheng W, Sung CJ, Hanna I, DePetris G, Lambert-Messerlian G, Steinhoff M, et al. Alpha and beta subunits of inhibin/activin as sex cord-stromal differentiation markers. Int J Gynecol Pathol 1997;16:263-71.
6. Spencer SJ, Rabinovici J, Mesiano S, Goldsmith PC, Jaffe RB. Activin and inhibin in the human adrenal gland. Regulation and differential effects in fetal and adult cells. J Clin Invest 1992;90:142-9.
7. Munro LMA, Kennedy A, McNicol AM. The expression of inhibin/activin subunits in the human adrenal cortex and its tumours. J Endocrinol 1999;161:341-7.
8. Ucella S, La Rosa S, Genasetti A, Capella C. Localization of inhibin/activin subunits in normal pituitary and pituitary adenomas. Pituitary 2000;3:131-9.
9. McCluggage WG, Maxwell P, Sloan JM. Immunohistochemical staining of ovarian granulosa cell tumors with monoclonal antibody against inhibin. Hum Pathol 1997;28:1034-8.
10. Rishi M, Howard LN, Bratthauer GL, Tavassoli FA. Use of monoclonal antibody against human inhibin as a marker for sex cord-stromal tumors of the ovary. Am J Surg Pathol 1997;21:583-9.
11. Zheng W, Lu JJ, Luo F, Hsieh J, Wang CY, Zhang C, et al. Tumor stroma as the main source of inhibin production in ovarian epithelial tumors. Am J Reprod Immunol 2000;44:104-13.
12. McCluggage WG, Shanks JH, Whiteside C, Maxwell P, Banerjee SS, Biggart JD. Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. Am J Surg Pathol 1998;22:615-9.
13. Iczkowski K, Bostwick D, Roche P, Cheville J. Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. Mod Pathol 1998;11:774-9.
14. Choi YL, Kim HS, Ahn G. Immunoexpression of inhibin alpha subunit, inhibin/activin betaA subunit and CD99 in ovarian tumors. Arch Pathol Lab Med 2000;124:563-9.
15. Pelkey T, Frierson H Jr, Mills S, Stoler M. The a subunit of inhibin in adrenal cortical neoplasia. Mod Pathol 1998;11: 516-24.
16. Renshaw A, Granter S. A comparison of A103 and inhibin reactivity in adrenal cortical tumors: distinction from hepatocellular carcinoma and renal tumors. Mod Pathol 1998;11: 1160-4.
17. Arola J, Liu J, Heikkila P, Ilvesmaki V, Salmenkivi K, Voutilainen R, et al. Expression of inhibin a in adrenocortical tumours reflects the hormonal status of the neoplasm. J Endocrinol 2000;165:223-9.
18. Stewart CJ, Jeffers MD, Kennedy A. Diagnostic value of inhibin immunoreactivity in ovarian gonadal stromal tumours and their histological mimics. Histopathology 1997;31:67-74.
19. Costa MJ, Ames PF, Walls J, Roth LM. Inhibin immunohistochemistry applied to ovarian neoplasms: a novel, effective diagnostic tool. Hum Pathol 1997;28:1247-54.
20. Pelkey T, Frierson H Jr, Mills S, Stoler M. The diagnostic utility of inhibin staining in ovarian neoplasms. Int J Gynecol Pathol 1998;17:97-105.
21. Wells M. Making sense of inhibin in ovarian tumors. Histopathology 1998;32:81-3.
22. McCluggage WG. Value of inhibin staining in gynecological pathology. Int J Gynecol Pathol 2001;20:79-85.
23. Oliva E, Young RH, Amin MB, Clement PB. An immunohistochemical analysis of endometrial stromal and smooth muscle tumors of the uterus: a case of 54 cases emphasizing the importance of using a panel because of overlap in immunoreactivity for individual antibodies. Am J Surg Pathol 2002;26:403-12.
24. Taylor CR, Shi S-R, Barr NJ, Wu N. Techniques of immunohistochemistry: principles, pitfalls, and standardization. In: Dabbs DJ, editor. Diagnostic immunohistochemistry. Philadelphia: Churchill-Livingstone; 2002. p. 3-43.
25. Busam KJ, Iversen K, Coplan KA, Old LJ, Stockert E, Chen Y-T, et al. Immunoreactivity for A103, an antibody to Melan-A (Mart-1), in adrenocortical and other steroid tumors. Am J Surg Pathol 1998;22:57-63.
26. Cote RJ, Cordon-Cardo C, Reuter VE, Rosen PP. Immunopathology of adrenal and renal cortical tumors: coordinated change in antigen expression is associated with neoplastic conversion in the adrenal cortex. Am J Pathol 1990;136:1077-84.
27. DeLellis RA, Shin SJ. Diagnostic immunohistochemistry of endocrine tumors. In: Dabbs DJ, editor. Diagnostic immunohistochemistry. Philadelphia: Churchill-Livingstone; 2002. p. 209-40.
28. Wick MR, Cherwitz DL, McGlennen RC, Dehner LP. Adrenocortical carcinoma: an immunohistochemical comparison with renal cell carcinoma. Am J Surg Pathol 1986;122:343-52.
29. DeYoung BR, Wick MR, Fitzgibbon JF, Sirgi KE, Swanson PE. CD31: an immunospecific marker for endothelial differentiation in human neoplasms. Appl Immunol 1993; 1(2):97-103.