Enzymatic resolution of a quaternary stereogenic centre as the key step in the synthesis of (S)-(+)-citalopram

Tetrahedron Asymmetry

Volumn 15, Issue 2, 2004, Pages 341-345

  Solares, Laura F ^a   Brieva, Rosario ^a   Quirós, Margarita ^b   Llorente, Isidro ^b   Bayod, Miguel ^b   Gotor, Vicente ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

^b Astur Pharma SA Poligono I   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

4 [(4 DIMETHYLAMINO) 1 (4' FLUOROPHENYL) 1 HYDROXY 1 BUTYL] 3 (HYDROXYMETHYL)BENZONITRILE; BENZONITRILE; BENZYL ALCOHOL; CITALOPRAM; FUNGAL ENZYME; LIPASE B; METHYL GROUP; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CANDIDA ANTARCTICA; CATALYSIS; CATALYST; CHEMICAL REACTION; CONTROLLED STUDY; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; ENZYME ACTIVITY; HYDROLYSIS; NONHUMAN; PRECURSOR; PRIORITY JOURNAL;

EID: 0346339486     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetasy.2003.10.022     Document Type: Article

References (9)

1. Gravem A., Amthor K.F., Astrup C., Elgen K., Gjessing L.R., Gunby B., Pettersen R.D., Kyrdalen L., Vaadal J., Ofsti E. Acta Psych. Scand. 75:1987;478-486.
2. Boegeso, K. P. EP Patent 0347066, 1989; Chem. Abstr. 1990, 113, 78150.
3. Boegeso, K. P. U.S. Patent 4,650,884, 1987; EP 171943, Chem. Abstr. 1986, 105, 42560.
4. Bech Sommer, M.; Nielsen, O.; Pedersen, H.; Ahmadian, H.; Pedersen, H.; Brosen, P.; Geiser, F.; Lee, J.; Cox, G.; Dapremont, O.; Steu, C.; Assenza, S. P.; Hariharan, S.; Nair, U. WO Patent 03/006449, 2003.
5. Schmid A., Dordick J.S., Hauer B., Kiener A., Wubbolts M., Witholt B. Nature. 409:2001;258-268.
6. Hari Krishna S., Persson M., Bornscheuer U.T. Tetrahedron: Asymmetry. 13:2002;2693-2696.
7. Henke E., Pleiss J., Bornscheuer U.T. Angew. Chem., Int. Ed. 41:2002;3211-3213.
8. Chen C.S., Fujimoto Y., Girdaukas G., Sih C.J. J. Am. Chem. Soc. 104:1982;7294-7299.
9. Bayod, M.; Llorente, I.; Gotor, V.; Quirós, M.; Fernández-Solares, L.; Brieva, R. ES Patent application P200302215 to Astur Pharma.