Longer survival of rat limb allograft: Combined immunosuppression of FK-506 and 15-deoxyspergualin

Acta Orthopaedica Scandinavica

Volumn 68, Issue 6, 1997, Pages 581-585

  Muramatsu, Keiichi ^a,c   Doi, Kazuteru ^b   Akino, Tatsuaki ^a   Shigetomi, Mitsunori ^a   Kawai, Shinya ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Ogori Daiichi Hospital

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXYSPERGUALIN; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; TACROLIMUS;

ALLOGRAFT; ALLOTRANSPLANTATION; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GRAFT REJECTION; GRAFT SURVIVAL; HINDLIMB; IMMUNOSUPPRESSIVE TREATMENT; NONHUMAN; RAT;

EID: 0031449208     PISSN: 00016470     EISSN: None     Source Type: Journal    
DOI: 10.3109/17453679708999031     Document Type: Article

References (21)

1. Arai K, Hotokebuchi T, Miyahara H. Limb allografts in rats immunosuppressed with FK-506. Transplantation 1989; 48: 782-6.
2. Black K S, Hewitt C W, Fraser L A. Comas and damian in the laboratory. N Eng J Med 1982; 306: 368-9.
3. Borel J F, Feurer C, Gubler H U, Stahlin H. Biological effects of Cyclosporin A: A new anti-lymphocytic agent. Agents Actions 1976; 6: 468-75.
4. Carobbi A, Arenada D, Patselas T. Effect of splenectomy in combination with FK-506 and 15-deoxyspergualin on cardiac xenograft survival. Transplant Proc 1993; 23: 549-50.
5. Collier D, Calne R, Thiru S. 15-deoxyspergualin in experimental dog renal allografts. Transplant Proc 1988; 20: 240-1.
6. Doi K. Homotransplantation of limbs in rats. Plast Reconstr Surg 1979; 64: 613-21.
7. Fealy M J, Umansky W S, Bickel K D, Nino J J. Efficacy of rapamycin and FK-506 in prolonging rat hind limb allograft survival. Ann Surg 1994; 219: 88-93.
8. Goto T, Kino T, Hatanaka H. Discovery of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis. Transplant Proc 1987; 19: 4-8.
9. Hotokebuchi T, Arai K, Arita C, Sugioka Y, Kaibara N. Limb allografts in rats immunosuppressed with Cyclosporine: as a whole joint allograft. Plast Reconstr Surg 1989; 83: 1027-36.
10. Kuroki H, Ishida O, Y Ikuta. Morphological and immunological analysis of rats with long-term surviving limb allografts induced by a short course of FK-506 or Cyclosporine. Transplant Proc 1991; 23: 516-20.
11. Min Z, Jones N F. Limb transplantation in rats: immunosuppression with FK-506. J Hand Surg 1995; 20A: 77-87.
12. Muramatsu K, Doi K, Kawai S. Vascularized allogeneic joint, muscle and peripheral nerve transplantation. Clin Orthop 1995; 320: 194-204.
13. Nakajima K, Sakamoto K, Ochiai T. Prolongation of cardiac xenograft survival in rats treated with 15-deoxyspergualin alone and in combination with FK-506. Transplantation 1988; 45: 1146-51.
14. Nemoto K, Sugawara Y, Mae T. Therapeutic activity of deoxyspergualin in comparison with cyclosporin A and its combined use with cyclosporin A and prednisolone in highly allogeneic skin transplantation in the rat. Agents Actions 1992; 36: 306-11.
15. Schubert G, Stoffregen C, Loske G. Synergistic effect of 15-deoxyspergualin and Cyclosporin A in pancreatic transplantation. Transplant Proc 1989; 21: 1096.
16. Suzuki S, Kanashiro M, Amemiya H. Effect of 15-deoxyspergualin on rejection detected by 31P nuclear magnetic resonance spectroscopy and in vivo mechanisms of action in rat heart transplantation. In: Deoxyspergualin immunosuppressive properties (Ed. H Amemiya). Appleton & Lange, New York 1989; 9-10.
17. Tufveson G, Gannedahl G. Deoxyspergualin-A different and intriguing immunosuppressant. Transplant Proc 1994; 26: 3029-39.
18. Umezawa H, Moriguchi M, Takeuchi T. Suppression of tissue graft rejection by spergualin. J Antibiot 1985; 38: 283-93.
19. Walter P, Dickenite G, Feifel G, Thies J. Deoxyspergualin induces tolerance in allogeneic kidney transplantation. Transplant Proc 1987; 19: 3980-1.
20. Walter P, Menger J, Dickenite G. Prolongation of graft survival in allogeneic limb transplantation by 15-deoxyspergualin. In: Deoxyspergualin immunosuppressive properties (Ed. H Amemiya). Appleton & Lange, New York 1989; 41-3.
21. Yuh D D, Morris R E. The immunopharmacology of immunosuppression by 15-deoxyspergualin. Transplantation 1993; 55: 578-91.