Understanding the role of the CD40-CD40L interaction in resistance to parasitic infections

Parasite Immunology

Volumn 25, Issue 4, 2003, Pages 179-183

  Wilson, Emma H ^a   Hunter, Christopher A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

CD40; CD40L; Cryptosporidium; Helminth; Immunoregulation; Leishmania; Toxoplasma

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND;

ARTICLE; CELL INTERACTION; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; CYTOKINE PRODUCTION; HELMINTH; HELMINTHIASIS; HUMAN; IMMUNOREGULATION; LEISHMANIA; LEISHMANIASIS; NONHUMAN; PARASITE IMMUNITY; PARASITOSIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ANIMALS; ANTIGENS, CD40; CD40 LIGAND; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; HELMINTHIASIS; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; LEISHMANIASIS; MODELS, IMMUNOLOGICAL; PARASITIC DISEASES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TOXOPLASMOSIS;

CRYPTOSPORIDIUM; CRYPTOSPORIDIUM PARVUM; TOXOPLASMA; TOXOPLASMA GONDII; VERMES;

EID: 0346250106     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3024.2003.00624.x     Document Type: Article

References (47)

1. Arpin C, Dechanet J, Van Kooten C et al. Generation of memory B cells and plasma cells in vitro. Science 1995; 268: 720-722.
2. Notarangelo LD, Duse M & Ugazio AG. Immunodeficiency with hyper-IgM (HIGM). Immunodefic Rev 1992; 3: 101.
3. Allen RC, Armitage RJ, Conley ME et al. CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science 1993; 259: 990-993.
4. Aruffo A, Farrington M, Hollenbaugh D et al. The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome. Cell 1993; 72: 291.
5. Callard RE, Smith SH, Herbert J et al. CD40 ligand (CD40L) expression and B cell function in agammaglobulinemia with normal or elevated levels of IgM (HIM). J Immunol 1994; 153: 3295.
6. DiSanto JP, Bonnefoy JY, Gauchat JF, Fischer A & de Saint Basile G. CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM. Nature 1993; 361: 541.
7. Fuleihan R, Ramesh N, Loh R et al. Defective expression of the CD40 ligand in X-linked immunodeficiency with normal or elevated IgM (HIGMX-1). Proc Nat Acad Sci USA 1993; 90: 2170.
8. Korthauer U, Garf D, Mages HW et al. Defective expression of T cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. Nature 1993; 361: 539.
9. Levy J, Espanol-Boren T, Thomas C et al. Clinical spectrum of X-linked hyper-IgM syndrome. J Pediatr 1997; 131: 47-54.
10. Tsuge I, Matsuoka H, Nakagawa A et al. Necrotizing toxoplasmic encephalitis in a child with the X-linked hyper-IgM syndrome. Eur J Pediatr 1998; 157: 735-737.
11. Yap G, Pesin M & Sher A. IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen Toxoplasma gondii. J Immunol 2000; 165: 628-631.
12. Subauste CS, Wessendarp M, Sorensen RU & Leiva LE. CD40-CD40 ligand interaction is central to cell-mediated immunity against Toxoplasma gondii: patients with hyper IgM syndrome have a defective type-1 immune response which can be restored by soluble CD40L trimer. J Immunol 1999; 162: 6690-6700.
13. Subauste CS & Wessendarp M. Human dendritic cells discriminate between viable and killed Toxoplasma gondii: dendritic cell activation after activation with viable parasites results in CD28 and CD40 signaling that controls IL-12-dependent and independent T cell production of IFN-g. J Immunol 2000; 165: 1498-1505.
14. Zhou P & Seder RA. CD40 ligand is not essential for induction of type-1 cytokine responses or protective immunity after primary or secondary infection with Histoplasma capsulatum. J Exp Med 1998; 187: 1315-1324.
15. Campos-Neto A, Ovendale P, Bement T et al. Cutting Edge: CD40 ligand is not essential for the development of cell-mediated immunity and resistance to Mycobacterium tuberculosis. J Immunol 1998; 160: 2037-2041.
16. Reichmann G, Walker W, Villegas EN et al. The CD40/CD40 ligand interaction is required for resistance to toxoplasmic encephalitis. Infect Immun 2000; 68: 1312-1318.
17. Becher B, Blain M & Antel JP. CD40 engagement stimulates IL-12 p70 production by human microglial cells: basis for Th1 polarization in the CNS. J Neuroimmunol 2000; 102: 44-50.
18. Becher B, Durell BG, Miga AV, Hickey WF & Noelle RJ. The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system. J Exp Med 2001; 193: 967-974.
19. D'Aversa TG, Weidenheim KM & Berman JW. CD40-CD40L interactions induce chemokine expression by human microglia. Am J Path 2002; 160: 559-567.
20. Tan J, Town T, Mori T et al. CD40 is expressed and functional on neuronal cells. EMBO J 2002; 21: 643-652.
21. Jana M, Liu X, Koka S, Ghosh S, Petro TM & Pahan K. Ligation of CD40 stimulates the induction of nitric-oxide synthase in microglial cells. J Biol Chem 2001; 276: 44527-44533.
22. de Goer de Herve MG, Delfraissy JF & Taoufik Y. Following direct CD40 activation, human primary microglial cells produce IL-12 p40 but not bioactive IL-12 p70. Cytokine 2001; 14: 88-96.
23. Fischer H, Bonifas U & Reichmann G. Phenotype and functions of brain dendritic cells emerging during chronic infection of mice with Toxoplasma gondii. J Immunol 2000; 164: 4826-4834.
24. Cella M, Scheidegger D, Palmer-Lehmann K, Lane P, Lanzavechia A & Alber G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med 1996; 184: 747-752.
25. Cosyns M, Tsirkin S, Jones M, Flavell R, Kikutani H & Hayward AR. Requirement for CD40-CD40 ligand interaction for elimination of Cryptosporidium parvum from mice. Infect Immun 1998; 66: 603-607.
26. Hayward AR, Levy J, Facchetti F et al. Cholangiopathy and tumors of the pancreas, liver, and biliary tree in boys with X-linked immunodeficiency with hyper-IgM. J Immunol 1997; 158: 977-983.
27. Hayward AR, Cosyns M, Jones M & Ponnuraj EM. Marrow-derived CD40-positive cells are required for mice to clear Cryptosporidium parvum infection. Infect Immun 2001; 69: 1630-1634.
28. Martin JC, Sancho T, Sierra FJ et al. Visceral leishmaniasis in a patient with hyper-IgM hypogammaglobulinemia. Clin Infect Dis 1996; 23: 1188-1189.
29. Campbell KA, Ovendale PJ, Kennedy MK, Fanslow WC, Reed SG & Maliszewski CR. CD40 ligand is required for protective cell-mediated immunity to Leishmania major. Immunity 1996; 4: 283-289.
30. Kamanaka M, Yu, P, Yasui T, Yoshida K et al. Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity. Immunity 1996; 4: 275-281.
31. Soong L, Jian-Chao X, Grewal IS et al. Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Immunity 1996; 4: 263-273.
32. Ferlin WG, von der Weid T, Cottrez F, Ferrick DA, Coffman & Howard MC. The induction of a protective response in Leishmania mojor-infected BALB/c mice with anti-CD40 mAb. Eur J Immunol 1998; 28: 525-531.
33. Marovich MA, McDowell MA, Thomas EK & Nutman TB. IL-12p70 production by Leishmania major-harboring human dendritic cells is a CD40/CD40 ligand-dependent process. J Immunol 2000; 164: 5858-5865.
34. Speirs K, Caamano J, Goldschmidt MH, Hunter CA & Scott P. NF-kB2 is required for optimal CD40-induced IL-12 production but dispensable for Th1 cell differentiation. J Immunol 2002; 168: 4406-4413.
35. Padigel UM, Perrin PJ & Farrell JP. The development of a Th1-type response and resistance to Leishmania major infection in the absence of CD40-CD40L costimulation. J Immunol 2000; 167: 5874-5879.
36. Padigel UM & Farrell JP. CD40-CD40 ligand costimulation is not required for initiation and maintenance of a Th1-type response to Leishmania major infection. Infect Immun 2003; 71: 1389-1395.
37. Lu P, Urban JF, Zhou XD et al. CD40-mediated stimulation contributes to lymphocyte proliferation, antibody production, eosinophilia, and mastocytosis during an in vivo type 2 response, but is not required for T cell IL-4 production. J Immunol 1996; 156: 3327-3333.
38. MacDonald AS, Straw AD, Dalton NM & Pearce EJ. Cutting edge: Th2 response induction by dendritic cells: a role for CD40. J Immunol 2002; 168: 537-540.
39. Martin DL, King CL, Pearlman E, Strine E & Heinzel FP. IFN-γ is necessary but not sufficient for anti-CD40 antibody-mediated inhibition of the Th2 response to Schistosoma mansoni eggs. J Immunol 2000; 164: 779-785.
40. MacDonald AS, Patton EA, La Flamme AC et al. Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40/CD154 interaction. J Immunol 2002; 168: 4643-4649.
41. Straw AD, MacDonald AS, Denkers EY & Pearce EJ. CD154 plays a central role in regulating dendritic cell activation during infections that induce Th1 or Th2 responses. J Immunol 2003; 170: 727-734.
42. Imai S, Tezuka H, Furuhashi Y, Muto R & Fujita K. A factor of inducing IgE from a filarial parasite is an agonist of human CD40. J Biol Chem 2000; 276: 46118-46124.
43. Tezuka H, Imai S, Tsukidate S & Fujita K. A Dirofilaria immitis polyprotein up-regulates nitric oxide production. Infect Immun 2002; 70: 5283-5286.
44. Van Overtvelt L, Vandereyde N, Verhasselt V et al. Trypanasoma cruzi infects human dendritic cells and prevents their maturation: Inhibition of cytokines, HLA-DR, and costimulatory molecules. Infect Immunol 1999; 67: 4033-4040.
45. Moutaftsi M, Mehl AM, Borysiewicz LK & Tabi Z. Human cytomegalovirus inhibits maturation and impairs function of monocyte-derived dendritic cells. Blood, 2002; 99: 2913-2921.
46. Uronen H & Callard RE. Absence of CD40-CD40 ligand interactions in X-linked hyper-IgM syndrome does not affect differentiation of T helper cell subsets. Clin Exp Immunol 2000; 121: 346-352.
47. + T cell memory. Science 2002; 297: 2060-2063.