Accumulation of 5-phosphoribosyl-1-pyrophosphate in human CCRF-CEM leukaemia cells treated with antifolates

International Journal of Biochemistry and Cell Biology

Volumn 36, Issue 3, 2004, Pages 545-551

  Kamal, M A ^a   Christopherson, R I ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

5 Phosphoribosyl 1 pyrophosphate; Amido phosphoribosyltransferase; Antifolates; CCRF CEM leukaemia; De novo purine biosynthesis

Indexed keywords

2,4 DIAMINO 6 (3,4,5 TRIMETHOXYANILINO)METHYLPYRIDO[3,2 D]PYRIMIDINE; 2,4 DIAMINO 6 (3,4,5 TRIMETHOXYBENZYL) 5,6,7,8 TETRAHYDROQUINAZOLINE; CARBON 14; CELLULOSE DERIVATIVE; FOLIC ACID ANTAGONIST; LOMETREXOL; METHOTREXATE; METODICLOROFEN; N [4 [2 (2 AMINO 3,4 DIHYDRO 4 OXO 7H PYRROLO[2,3 D]PYRIMIDIN 5 YL)ETHYL]BENZOYL]GLUTAMIC ACID; NALPHA (4 AMINO 4 DEOXYPTEROYL) NDELTA HEMIPHTHALOYLORNITHINE; OROTIC ACID; OROTIDINE; OROTIDINE 5' PHOSPHATE; PHOSPHORIBOSYL PYROPHOSPHATE; PIRITREXIM; POLY(ETHYLENEIMINE)CELLULOSE; PY 873; PY 899; UNCLASSIFIED DRUG; URIDINE PHOSPHATE;

ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG EFFECT; DRUG EXPOSURE; DRUG MECHANISM; DRUG POTENCY; ENZYME INHIBITION; EXTRACTION; HUMAN; HUMAN CELL; HYDROLYSIS; INHIBITION KINETICS; ISOLATION PROCEDURE; LEUKEMIA CELL; MEASUREMENT; QUANTITATIVE ANALYSIS; REACTION ANALYSIS; STEADY STATE; THIN LAYER CHROMATOGRAPHY; TIME;

EID: 0346219108     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2003.08.014     Document Type: Article

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