No Association between a Neuronal Nitric Oxide Synthase (NOS1) Gene Polymorphism on Chromosome 12q24 and Bipolar Disorder

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 124 B, Issue 1, 2004, Pages 73-75

  Buttenschön, Henriette N ^a   Mors, O ^a   Ewald, H ^a   McQuillin, A ^b   Kalsi, G ^b   Lawrence, J ^b   Gurling, H ^b   Kruse, T A ^c  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; NEURONAL NITRIC OXIDE SYNTHASE;

BIPOLAR DISORDER; CAUCASIAN; CHROMOSOME 12Q; DISEASE ASSOCIATION; GENE FREQUENCY; GENE FUNCTION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; LETTER; PRIORITY JOURNAL; SCHIZOPHRENIA; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED KINGDOM;

EID: 0346102510     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.20040     Document Type: Letter

References (11)

1. Bailer U, Leisch F, Meszaros K, Lenzinger E, Willinger U, Strobl R, et al. 2002. Genome scan for susceptibility loci for schizophrenia and bipolar disorder. Biol Psychiatry 52:40-52.
2. Bruun TG, Ewald H. 1999. Selection bias of susceptibility genes possible when using parent-offspring trios in genetic association studies. Mol Psychiatry 4:414-415.
3. Craddock N, Owen M, Burge S, Kurian B, Thomas P, McGuffin P. 1994. Familial cosegregation of major affective disorder and Darier's disease (keratosis follicularis). Br J Psychiatry 164:355-358.
4. Curtis D, Kalsi G, Sigmundsson Th, McInnis M, O'Neill J, Smyth C, Moloney M, Murphy P, McQuillin A, Gurling H. 2003. Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p36 and 1q42. Psychiatr Genet (in press).
5. Degn B, Lundorf MD, Wang A, Vang M, Mors O, Kruse TA, et al. 2001. Further evidence for a bipolar risk gene on chromosome 12q24 suggested by investigation of haplotype sharing and allelic association in patients from the Faroe Islands. Mol Psychiatry 6:450-455.
6. DeLisi LE, Shaw SH, Crow TJ, Shields G, Smith AB, Larach VW, et al. 2002. A genome-wide scan for linkage to chromosomal regions in 382 siblings pairs with schizophrenia or schizoaffective disorder. Am J Psychiatry 159:803-812.
7. Ewald H, Degn B, Mors O, Kruse TA. 1998. Significant linkage between bipolar affective disorder and chromosome 12q24. Psychiatr Genet 8:131-140.
8. Ewald H, Flint T, Kruse TA, Mors O. 2002. A genomewide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22-21, 4p16, 6q14-22, 10q26 and 16p13.3. Mol Psychiatry 7:734-744.
9. Jones I, Jacobsen N, Green EK, Elvidge GP, Owen MJ, Craddock N. 2002. Evidence for familial cosegregation of major affective disorder and genetic markers flanking the gene for Darier's disease. Mol Psychiatry 7:424-427.
10. Morissette J, Villeneuve A, Bordeleau L, Rochette D, Laberge C, Gagne B, et al. 1999. Genome-wide search for linkage of bipolar affective disorders in a very large pedigree derived from a homogeneous population in quebec points to a locus of major effect on chromosome 12q23-q24. Am J Med Genet 88:567-587.
11. Shinkai T, Ohmori O, Hori H, Nakamura J. 2002 Allelic association of the neuronal nitric oxide synthase (NOS1) gene with schizophrenia. Mol Psychiatry 7:560-563.