Induction of NAD(P)H:quinone Reductase by Probucol: A Possible Mechanism for Protection against Chemical Carcinogenesis and Toxicity

Pharmacology and Toxicology

Volumn 93, Issue 6, 2003, Pages 259-263

  Iqbal, Mohammad ^a   Okada, Shigeru ^a  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROBUCOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CHEMICAL CARCINOGENESIS; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CYTOSOL; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INDUCTION; ENZYME LOCALIZATION; FORESTOMACH; HEART; KIDNEY; LIVER; LUNG; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; SPLEEN;

ANIMALS; ANTIOXIDANTS; ENZYME INDUCTION; MALE; MICE; NAD(P)H DEHYDROGENASE (QUINONE); NADP; NEOPLASMS; PROBUCOL; TISSUE DISTRIBUTION;

ANIMALIA; RODENTIA;

EID: 0346041544     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.2003.pto930602.x     Document Type: Article

References (32)

1. Batzinger, R. P., S. Y. L. Ou & E. Bueding: Anti-mutagenic effects of 2(3)-tert-butyl-4-hydroxyanisole and of antimicrobial agents. Cancer Res. 1978, 38, 4476-4483.
2. Belinsky, M. & A. K. Jaiswal: NAD(P)H:quinone oxidoreductase 1 (DT-diaphorase) expression in normal and tumor tissues. Cancer Metast. Rev. 1993, 12, 103-117.
3. Benson, A. M., M. J. Hunkeler & P. Talalay: Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity. Proc. Natl. Acad. Sci. USA 1980, 77, 5216-5220.
4. Dage, R. C., B. A. Anderson, S. J. Mao & J. E. Koerner: Probucol reduced myocardial dysfunction during reperfusion after short-term ischemia in rabbit heart. J. Cardiovasc. Pharmacol. 1991, 17, 158-165.
5. El-Demerdash, E., E. El-Denshary, M. El-Didi, N. Al-Gharabli & A-M. M. Osman: Probucol and liver efficiency during chemically induced hepatocarcinogenesis. Anticancer Res. 2002, 22, 977-984.
6. Ernster, L.: DT diaphorase. In: Methods in enzymology. Eds: R. W. Estabrook and M. E. Pullman. Academic Press, New York, 1967 pp. 309-317.
7. Favreau, L. V. & C. B. Pickett: Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Identification of regulatory elements controlling basal level expression and inducible expression by planar aromatic compounds and phenolic antioxidants. J. Biol. Chem. 1991, 266, 4556-4561.
8. Gordon, G. B., H. J. Prochaska & L. Y. S. Yang: Induction of NAD(P)H:quinone reductase in human peripheral blood lymphocytes. Carcinogenesis 1991, 12, 2393-2396.
9. Grantham, P. H., J. H. Weisburger & E. K. Weisburger: Effect of antioxidant butylated hydroxytoluene (BHT) on the metabolism of the carcinogens N-2-fluorenylacetamide and N-hydroxy-N-2-flurenylacetamide. Food Cosmet. Toxicol. 1973, 11, 209-217.
10. Hu, Z. & P. G. Wells: In vitro and in vivo biotransformation and covalent binding of benzo(a)pyrene in Gunn and Rha rats with a genetic deficiency in bilirubin uridine diphosphate UDP-glucuronosyltranfearse. J. Pharmacol. Exp. Therap. 1992, 263, 334-342.
11. Iqbal, M., H. Rezazadeh, S. Ansar & M. Athar: ∝-Tocopherol ameliorates ferric nitrilotriacetate-dependent renal proliferative response and toxicity: diminution of oxidative stress. Human Exp. Toxicol. 1998, 17, 163-171.
12. Iqbal, M., U. Giri, D. K. Giri, M. S. Alam & M. Athar: Age dependent renal accumulation of 4-hydroxy-2-nonenal (HNE)-modified proteins following parental administration of ferric nitrilotriacetate commensurate with its differential toxicity: implications for the involvement of HNE-protein adducts in oxidative stress and carcinogenesis. Arch. Biochem. Biophys. 1999a, 365, 101-112.
13. Iqbal, M., S. D. Sharma, A. Rahman, P. Trikha & M. Athar: Evidence that ferric nitrilotriacetate mediates oxidative stress by down-regulating DT-diaphorase activity, implications for carcinogenesis. Cancer Lett. 1999, 141, 151-157.
14. Iqbal, M., S. D. Sharma, Y. Okazaki, M. Fujisawa & S. Okada: Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY mice: Possible role in protection against chemical carcinogenesis and toxicity. Pharmacology & Toxicology 2003, 92, 33-38.
15. Kahl, R.: Synthetic antioxidants: biochemical actions and interference with radiation toxic compounds, chemical mutagens and chemical carcinogens. Toxicology 1984, 33, 185-228.
16. Kuzuya, M. & F. Kuzuya: Probucol as an antioxidant and antiatherogenic drug. Free Rad. Biol. Med. 1993, 14, 67-77.
17. Lafuente, A., F. Pujol, P. Carretero, J. Perez Villa & A. Cuchi: Human glutathione S-transferase μ (GST μ) deficiency as a marker for the susceptibility to bladder and larynx cancer among smokers. Cancer Lett. 1993, 68, 49-54.
18. Li, Y. & A. K. Jaiswal: Regulation of human NAD(P)H:quinone oxidoreductase gene. Role of AP1-binding site contained with in human antioxidant responsive element. J. Biol. Chem. 1992, 267, 15097-15104.
19. Nishimura, G., S. Yanoma, H. Mizuno, K. Kawakami & M. Tsukuda: An antioxidant, probucol, induces anti-angiogenesis and apoptosis in athymic nude mouse xenografted human head and neck squamous carcinoma cells. Jap. J. Cancer Res. 1999, 90, 1224-1230.
20. Parthasarathy, S.: Evidence for an additional intracellular site of action of probucol in the prevention of oxidative modification of low-density lipoprotein. Use of new water-soluble probucol derivative. J. Clin. Invest. 1992, 89, 1618-1621.
21. Prestera, T., Y. Zhang, S. R. Spencer, C. A. Wilczak & P. Talalay: The electrophillic counterattack response: protection against neoplasia and toxicity. Adv. Enzyme Reg. 1993, 33, 281-296.
22. Qin, S., S. Zhang, M. Zarkovic, Y. Yamazaki, H. Oda, Y. Nakatsuru & T. Ishikawa: Inhibitory effect of probucol on nephrotoxicity induced by ferric nitrilotriacetate in rats. Carcinogenesis 1995, 16, 2549-2552.
23. Rushmore, T. H. & C. B. Pickett: Transcriptional regulation of rat glutathione S-transferase Ya subunit gene. Characterization of a xenobiotics-responsive element controlling inducible expression by phenolic antioxidants. J. Biol. Chem. 1990, 265, 14648-14653
24. Rushmore, T H., M. R. Morton & C. B. Pickett: The antioxidant response element. Activation by oxidative stress and identification of DNA consensus sequence required for functional activity. J. Biol. Chem. 1991, 266, 11632-11639.
25. Seidegard, J., R. W. Pero, M. M. Markowitz, G. Roush, D. G. Miller & E. J. Beatine: Isozyme (s) of glutathione transferase (class μ) as a marker for the susceptibility to lung cancer: a follow up study. Carcinogenesis (Lond.), 1990, 11, 33-36.
26. Siveski-Iliskovic, N., M. Hill, D. A. Chow & P. K. Singal: Probucol protects against adriamycin cardiomyopathy without interfering with its antitumor effect. Circulation 1995, 91, 10-15.
27. Siveski-Iliskovic, N., B. B. Hasinoff, K. L. Malisza, I. Danielson & P. K. Singal: Mechanisms of beneficial effects of probucol in adriamycin cardiomyopathy. Mol. Cell. Biochem. 1999, 196, 43-49.
28. Spencer, S. R., A. A. Wilczak & P. Talalay: Induction of glutathione transferases and NAD(P)H: quinone reductase by fumaric acid derivatives in rodent cells and tissues. Cancer Res. 1990, 50, 7871-7875.
29. Ulland, B. M., J. H. Weisburger, R. S. Yamamoto & E. K. Weisberger: Antioxidants and carcinogenesis: butylated hydroxytoluene, but not dipenyl-p-phenylenediamine, inhibits cancer induction by N-2-fluorenylacetamide and by N-hydroxy-N-2-flurenylacetamide in rats. Food Cosmet. Toxicol. 1973, 11, 199-207.
30. Wattenberg, L. W.: Inhibition of carcinogenic and toxic effects of polycyclic aromatic hydrocarbons by phenolic antioxidants and ethoxyquin. J. Natl. Cancer Inst. 1972, 48, 1425-1430
31. Wang, W & C. M. Higuchi: Induction of NAD(P)H: quinone reductase by vitamins A, E and C in Colo205 colon cancer cells. Cancer Lett. 1995, 98, 63-69.
32. Zarkovic, M., X, Qin, Y. Nakatsuru, S. Zhang, Y. Yamazaki, H. Oda, T. Ishikawa & T. Ishikawa: Inhibitory effect of probucol on benzo[a]pyrene induced lung tumorigenesis. Carcinogenesis 1995, 16, 2599-2601.