High spontaneous colony growth in chronic myelomonocytic leukemia correlates with increased disease activity and is a novel prognostic factor for predicting short survival

Annals of Hematology

Volumn 83, Issue 1, 2004, Pages 9-13

  Sagaster, Verena ^a   Ohler L ^a   Berer, A ^a   Kabrna, E ^a   Ofner, P ^b   Lechner, K ^a   Geissler, K ^c  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

^c 3rd Medical Department Oncology   (Austria)

Author keywords

Chronic myelomonocytic leukemia; Colony growth; Survival

Indexed keywords

CLADRIBINE; CYCLOPHOSPHAMIDE; CYTARABINE; CYTOKINE; ETOPOSIDE; HYDROXYUREA; IDARUBICIN; INTERLEUKIN 10;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ARTICLE; BLAST CELL; BLOOD TRANSFUSION; BONE MARROW; CANCER SURVIVAL; CELL GROWTH; CHRONIC MYELOMONOCYTIC LEUKEMIA; CLINICAL ARTICLE; COLONY FORMING UNIT GM; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKOCYTE COUNT; LEUKOCYTE CULTURE; MALE; MALIGNANT TRANSFORMATION; MONONUCLEAR CELL; PREDICTION; PRIORITY JOURNAL; PROBABILITY; PROGNOSIS; SPLENOMEGALY; STATISTICAL SIGNIFICANCE; SURVIVAL TIME; THROMBOCYTE COUNT;

AGED; AGED, 80 AND OVER; COLONY-FORMING UNITS ASSAY; FEMALE; GRANULOCYTES; HUMANS; LEUKEMIA, MYELOMONOCYTIC, CHRONIC; MACROPHAGES; MALE; MIDDLE AGED; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RISK; SURVIVAL ANALYSIS; TUMOR STEM CELLS;

EID: 0346007924     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-003-0743-9     Document Type: Article

References (17)

1. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1982) Proposals for the classification of the myelodysplastic syndromes. The French-American-British (FAB) Co-operative Group. Br J Haematol 51:189-199
2. Cox DR (1972) Regression models and life-tables. J R Stat Soc B 34:187-220
3. De Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE (1991) Interleukin-10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 174:1209-1220
4. Everson MP, Brown CB, Lilly MB (1989) Interleukin-6 and granulocyte-macrophage colony-stimulating factor are candidate growth factors for chronic myelomonocytic leukemia cells. Blood 74:1472-1476
5. Fenaux P, Beuscart R, Lai JL, Jouet JP, Bauters F (1988) Prognostic factors in adult chronic myelomonocytic leukemia: an analysis of 107 cases. J Clin Oncol 6:1417-1424
6. Geary CG, Catovsky D, Wiltshow E, Milner GR, Scholes MC, Van Noorden S, Wadworth LD, Muldal S, MacIver JE, Galton DAG (1975) Chronic myelomonocytic leukemia. Br J Haematol 30:289-302
7. Geissler K, Hinterberger W, Bettelheim P, Haas O, Lechner K (1988) Colony growth characteristics in chronic myelomonocytic leukemia. Leuk Res 12:373-377
8. Geissler K, Öhler L, Födinger M, Virgolini I, Leimer M, Kabrna E, Kollars M, Skoupy S, Bohle B, Rogy M, Lechner K (1996) Interleukin 10 inhibits growth and granulocyte/macrophage colony-stimulating factor production in chronic myelomonocytic leukemia cells. J Exp Med 184:1377-1384
9. Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, Lister TA, Bloomfield CD (1999) World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997. JCO 17:3835-3849
10. Kaplan EL, Meier P (1958) Non parametric estimation from incomplete observations. J Am Stat Assoc 53:457
11. Mantel N (1966) Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50:163-170
12. Oehler L, Foedinger M, Koeller M, Kollars M, Reiter E, Bohle B, Skoupy S, Fritsch G, Lechner K, Geissler K (1997) Interleukin-10 inhibits spontaneous colony-forming unit-granulocyte-macrophage growth from human peropheral blood mononuclear cells by suppression of endogenous granulocyte-macrophage colony-stimulating factor release. Blood 89:1147-1153
13. Onida F, Kantarjian HM, Smith TL, Ball G, Keating MJ, Estey EH, Glassman AB, Albitar M, Kwari MI, Beran M (2002) Prognostic factors and scoring systems in chronic myelomonocytic leukemia: a retrospective analysis of 213 patients. Blood 99:840-849
14. Schrader JW (1993) Re-examining the autocrine loop in acute myeloid leukaemia. Adv Cancer Ther 4:5-16
15. Solal-Celigny P, Desaint B, Herrera A, Chastang C, Amar M, Vroclans M, Brousse N, Mancilla F, Renoux M, Bernard JF, Boivin P (1984) Chronic myelomonocytic leukemia according to FAB classification: analysis of 35 cases. Blood 63:634-638
16. Wattel E, Guerci A, Hecquet B, Economopoulos T, Copplestone A, Mahe B, Couteaux ME, Resegotti L, Voglova V, Foussard C, Pegourie B, Michaux JL, Deconinck E, Stoppa AM, Mufti G, Oscier D, Fenaux P, Groupe Francais des Myeodysplasies and European CMML Group (1996) A randomized trial of hydroxyurea versus VP16 in adult chronic myelomonocytic leukemia. Blood 88:2480-2487
17. Worsley A, Oscier DG, Stevens J, Darlow S, Ann Figes, Mufti GJ, Hamblin TJ (1988) Prognostic features of chronic myelomonocytic leukaemia: a modified Bournemouth score gives the best prediction of survival. Br J Haematol 68:17-21