Passive transfer of purified IgG from patients with amyotrophic lateral sclerosis to mice results in degeneration of motor neurons accompanied by Ca2+ enhancement

Acta Neuropathologica

Volumn 107, Issue 1, 2004, Pages 35-46

  Pullen, A H ^a   Demestre, M ^a   Howard, R S ^b   Orrell, R W ^b,c  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Amyotrophic lateral sclerosis; Antibodies; Cytotoxicity; Degeneration; Motor neurone; Serum

Indexed keywords

CALCIUM ION; FIXATIVE; IMMUNOGLOBULIN G; PROTEIN A;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL COUNT; CELL KILLING; CELL NUCLEUS MEMBRANE; CELL ORGANELLE; CELL STRUCTURE; CELL ULTRASTRUCTURE; CHROMATIN CONDENSATION; CLINICAL ARTICLE; CONTROLLED STUDY; DENSITOMETRY; DIALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOCHEMISTRY; HISTOPATHOLOGY; HUMAN; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MOTONEURON; MOUSE; NERVE CELL CULTURE; NERVE CELL DEGENERATION; NONHUMAN; PARAPROTEINEMIA; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; PROTEIN TARGETING; SPINAL CORD;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; APOPTOSIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON; MIDDLE AGED; MOTOR NEURONS; NERVE DEGENERATION; SPINAL CORD;

EID: 0345868837     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-003-0777-z     Document Type: Article

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