Uptake of immunoglobulin G from amyotrophic lateral sclerosis patients by motor nerve terminals in mice

Journal of the Neurological Sciences

Volumn 137, Issue 2, 1996, Pages 97-102

  Fratantoni, Silvina A ^a   Dubrovsky, Alberto L ^b   Uchitel, Osvaldo D ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b HOSPITAL FRANCÉS   (Argentina)

Author keywords

Amyotrophic lateral sclerosis (ALS); Immunocytochemistry; Immunoglobulin G; Motoneuron; Uptake

Indexed keywords

IMMUNOGLOBULIN G;

ADULT; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MALE; MOTONEURON; MOUSE; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RETROGRADE NERVE FIBER TRANSPORT;

EID: 0029945079     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-510X(95)00345-3     Document Type: Article

References (39)

1. Alexianu, M.E., A. Habib Mohamed, R.G. Smith, L.V. Colom and S.H. Appel (1994) Apoptotic cell death of a hybrid motoneuron cell line induced by immunoglobulins from patients with amyotrophic lateral sclerosis. J. Neurochem., 63: 2365-2368.
2. Appel, S.H., V. Stockton-Appel, S.S. Stewart and R.H. Kerman (1986) Amyotrophic lateral sclerosis: associated clinical disorders and immunologic evaluation. Arch. Neurol., 43: 234-238.
3. Appel, S.H., J.I. Engelhardt, J. Garcia and E. Stefani (1991a) Immunoglobulins from animal models of motor neuron disease and human ALS patients passively transfer physiological abnormalities to the neuromuscular junction. Proc. Natl. Acad. Sci. USA, 88: 647-651.
4. Appel, S.H., J.I. Engelhardt, J. Garcia and E. Stefani (1991b) Rowland, L.P. (Ed.), Advances in Neurology, Vol. 56, Raven Press, New York, NY, pp. 405-412.
5. Borges, L.F. and N.A. Busis (1985) Intraneuronal accumulation of myeloma proteins. Arch. Neurol., 42: 690-694.
6. Broadwell, R.D. and M.W. Brightman (1976) Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood. J. Comp. Neurol., 166: 257-284.
7. Brown, R.H., D. Johnson, M. Ogomowsky et al. (1987) Type 1 human poliovirus binds to human synaptosomes. Ann. Neurol., 21: 64-70.
8. Delbono, O., J. Garcia, S.H. Appel and E. Stefani (1991) Calcium current and charge movement of mammalian muscle: action of amyotrophic lateral sclerosis immunoglobulins. J. Physiol. (Lond.), 444: 723-742.
9. Engelhardt, J.I., S.H. Appel, J.M. Killian (1989) Experimental autoimmune motoneuron disease. Ann. Neurol., 26: 368-376.
10. Engelhardt, J.I., S.H. Appel and J.M. Killian (1990) Motor neuron destruction in guinea pigs immunized with bovine ventral horn homogenate: experimental autoimmune gray matter disease. J. Neuroimmunol., 27: 21-31.
11. Fabian, R.H. (1988) Uptake of plasma IgG by CNS motoneurons: comparison of antineuronal and normal IgG. Neurology, 38: 1775-1780.
12. Fabian, R.H. (1990) Uptake of antineuronal IgM by CNS neurons: comparison with antineuronal IgG. Neurology, 40: 419-422.
13. Fabian, R.H. and G. Petroff (1987) Intraneuronal IgG in the CNS: uptake by retrograde axonal transport. Neurology, 37: 1780-1784.
14. Fabian, R.H. and T.C. Ritchie (1986) Intraneuronal IgG in the CNS. J. Neurol. Sci., 73: 257-267.
15. Fishman, P.S. and D.R. Carrigan (1988) Motoneuron uptake from the circulation of the binding fragment of tetanus toxin. Arch. Neurol., 45: 558-561.
16. Fishman, P.S., D.A. Farrand, D.A. Kristt (1990) Internalization of plasma proteins by cerebellar Purkinje cells. J. Neurol. Sci., 100: 43-49.
17. Fishman, P.S., D.A. Farrand, D.A. Kristt (1991) Penetration and internalization of plasma proteins in the human spinal cord. J. Neurol. Sci., 104: 166-175.
18. Haberman, E. (1978) Tetanus. In: Vinken, P.J. and Bruyn, G.W. (Eds.), Handbook of Clinical Neurology, North-Holland Publishing Co., Amsterdam, pp. 491-547.
19. Jubelt, B., G. Gallez-Hawkins, O. Narayan and R.T. Johnson (1980) Pathogenesis of human poliovirus infection in mice. I. Clinical and pathological studies. J. Neuropathol. Exp. Neurol., 39: 128-148.
20. Kawamata, T., H. Akiyama, T. Yamada and P.L. McGeer (1992) Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord. Am. J. Pathol., 140: 691-707.
21. 1 subunit. Ann. Neurol, 35: 164-171.
22. Klatzo, I. (1967) Neuropathological aspects of brain edema. J. Neuropathol. Exp. Neurol., 26: 1-14.
23. Llinás, R., M. Sugimori, B.D. Cherksey, et al. (1993) IgG from amyotrophic lateral sclerosis patients increases current through P-type calcium channels in mammalian cerebellar Purkinje cells and in isolated channel protein in lipid bilayer. Proc. Natl. Acad. Sci. USA, 90: 11743-11747.
24. Meeker, M.L., R.B. Meeker and J.N. Hayward (1987) Accumulation of circulating endogenous and exogenous immunoglobulins by hypothalamic magnocellular neurons. Brain Res., 423: 45-55.
25. Price, D.L. and J. Griffin (1975) Tetanus toxin: direct evidence for retrograde intra-axonal transport. Science, 188: 945-947.
26. Protti, D.A., R. Reisin, T.A. Mackinley and O.D. Uchitel Calcium channel blockers and transmitter release at the normal human neuromuscular junction. Neurology, in press.
27. Ritchie, T.C., R.H. Fabian, J.D. Coulter (1985) Axonal transport of antibodies to subcellular and protein fractions of rat brain. Brain Res., 343: 252-261.
28. Schwab, M.E. and H. Thoenen (1978) Selective binding, uptake and retrograde transport of tetanus toxin by nerve terminals in the rat iris. J. Cell Biol., 77: 1-13.
29. Shy, M.E., L.P. Rowland, T. Smith et al. (1986) Motor neuron disease and plasma cell dyscrasia. Neurology, 36: 1429-1436.
30. Smith, R.G., S. Hamilton, F. Hofmann, T. Schneider, W. Nastainczyk, et al. (1992) Serum antibodies to L-type calcium channels in patients with amyotrophic lateral sclerosis. New Engl. J. Med., 327: 1721-1728.
31. Smith, R.G., M.E. Alexianu, G. Crawford, O. Nyormoi, E. Stefani and S.H. Appel (1994) The cytotoxicity of immunoglobulins from amyotrophic lateral sclerosis on a hybrid motoneuron cell line. Proc. Natl. Acad. Sci. USA, 91: 3393-3397.
32. Sparrow, J.R. (1981) Immunocytochemical localization of plasma proteins in neuronal perikarya. Brain Res., 212: 159-163.
33. Troost, D., J.J. van den Oord, J.M.B.V. de Jong and D.F. Swaab (1989) Lymphocytic infiltration in the spinal cord of patients with amyotrophic lateral sclerosis. Clin. Neuropathol., 8: 289-294.
34. Uchitel, O.D. and D.A. Protti (1994) P-type calcium channels and transmitter release from nerve terminals. News Physiol. Sci., 9: 101-105.
35. Uchitel, O.D., S.H. Appel, F. Crawford, L. Sczcupak (1988) Immunoglobulins from amyotrophic lateral sclerosis patients enhance spontaneous transmitter release from motor-nerve terminals. Proc. Natl. Acad. Sci. USA, 85: 7371-7374.
36. Uchitel, O.D., F. Scornik, D.A. Protti, C.G. Fumberg, V. Alvarez, S.H. Appel (1992) Long-term neuromuscular dysfunction produced by passive transfer of amyotrophic lateral sclerosis immunoglobulins. Neurology, 42: 2175-2180.
37. Valtorta, F., R. Jahn, R. Fesce, P. Greengard and B. Ceccarelli (1988) Synaptophysin (p38) at the frog neuromuscular junction: its incorporation into the axolemma and recycling after intense quantal secretion. J. Cell Biol., 107: 2717-2727.
38. Wenthold, R.J., K.K. Skaggs and R.R. Reale (1984) Retrograde axonal transport of antibodies to synaptic membrane components. Brain Res., 304: 162-165.
39. Yamamoto, T., Y. Iwasaki, H. Konno, H. Iizuka and J. Zhao (1987) Retrograde transport and differential accumulation of serum proteins in motor neurons: implications for motor neuron diseases. Neurology, 37: 843-846.