Cholesterol synthesis inhibition distal to squalene upregulates biliary phospholipid secretion and counteracts cholelithiasis in the genetically prone C57L/J mouse

Gut

Volumn 53, Issue 1, 2004, Pages 136-142

  Clarke, G A ^a   Bouchard, G ^a   Paigen, B ^b   Carey, M C ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOCKING AGENT; CHOLESTEROL; CHOLESTEROL BIOSYNTHESIS INHIBITOR; ENZYME INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; OXIDOSQUALENE LANOSTEROL CYCLASE INHIBITOR; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; RO 48 8071; SQUALENE EPOXIDASE INHIBITOR; TU 2208; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL DIET; CHOLELITHIASIS; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INHIBITION; EXPERIMENTAL MOUSE; FEEDING; GALLSTONE; GENETIC PREDISPOSITION; HEPATOBILIARY SYSTEM; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; UPREGULATION;

ANIMALS; ANTICHOLESTEREMIC AGENTS; BENZOPHENONES; BILE; BILE CANALICULI; CHOLELITHIASIS; CHOLESTEROL; ENZYME INHIBITORS; GENETIC PREDISPOSITION TO DISEASE; INTRAMOLECULAR TRANSFERASES; LIPIDS; LIVER; MALE; MICE; MICE, INBRED AKR; MICE, INBRED C57BL; OXYGENASES; PHOSPHOLIPIDS; SQUALENE MONOOXYGENASE; THIOPHENES;

EID: 0345830637     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.53.1.136     Document Type: Article

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