Use of the local lymph node assay in the evaluation of the sensitizing potential of pharmaceutical process intermediates

Contact Dermatitis

Volumn 49, Issue 3, 2003, Pages 148-154

  Durand, Geneviève ^a,c   De Burlet, Georges ^a   Virat, Michel ^a   Nauman, Bruce D ^b  

^a MSD Chibret   (France)

^b MERCK RESEARCH LABORATORIES   (United States)

^c Dohme Chibret Centre de Recherche Riom   (France)

Author keywords

Contact allergy; Guinea pig maximization test; Human data; Local lymph node assay; Potency estimation; Process intermediates; Risk assessment

Indexed keywords

CHEMICAL AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL WELFARE; ARTICLE; ASSAY; CONCENTRATION (PARAMETERS); CONTACT ALLERGY; CONTACT SENSITIZATION; CONTROLLED STUDY; DRUG INDUSTRY; DRUG MANUFACTURE; FEMALE; GUINEA PIG MAXIMIZATION TEST; HUMAN; LOCAL LYMPH NODE ASSAY; MOUSE; NONHUMAN; OCCUPATIONAL HAZARD; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY;

ALLERGENS; ANIMALS; DERMATITIS, ALLERGIC CONTACT; FEMALE; GUINEA PIGS; HUMANS; LOCAL LYMPH NODE ASSAY; MICE; MICE, INBRED CBA; PHARMACEUTICAL SOLUTIONS; PREDICTIVE VALUE OF TESTS;

EID: 0345802751     PISSN: 01051873     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0105-1873.2003.00197.x     Document Type: Article

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