Theoretical Study of Ribonucleotide Reductase Mechanism-Based Inhibition by 2′-Azido-2′-Deoxyribonucleoside 5′-Diphosphates

Journal of Computational Chemistry

Volumn 25, Issue 2, 2004, Pages 227-237

  Pereira, Susana ^a   Fernandes, Pedro Alexandrino ^a   Ramos, Maria João ^a  

^a UNIVERSITY OF PORTO   (Portugal)

Author keywords

2 azido 2 deoxyribonucleoside 5 diphosphate; DFT; Mechanism; Ribonucleotide reductase; RNR

Indexed keywords

CELLS; DISCRETE FOURIER TRANSFORMS; DNA; ENZYME INHIBITION; ESCHERICHIA COLI; METABOLISM; MOLECULAR BIOLOGY; MUTAGENESIS; NITROGEN COMPOUNDS; OPTIMIZATION; PERMITTIVITY; PHOSPHATES; STOICHIOMETRY; TUMORS; VIRUSES;

BINDING SITES; INTERNAL REACTION COORDINATES (IRC); RIBONUCLEOTIDE REDUCTASE; ZERO POINT ENERGIES;

ENZYMES;

DEOXYRIBONUCLEOSIDE; ENZYME INHIBITOR; RIBONUCLEOTIDE REDUCTASE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; ELECTRON SPIN RESONANCE; KINETICS; THERMODYNAMICS;

DEOXYRIBONUCLEOSIDES; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME INHIBITORS; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RIBONUCLEOTIDE REDUCTASES; THERMODYNAMICS;

EID: 0345763175     PISSN: 01928651     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcc.10375     Document Type: Article

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