Critical Role for the Oct-2/OCA-B Partnership in Ig-Secreting Cells

Journal of Immunology

Volumn 171, Issue 12, 2003, Pages 6589-6598

  Salas, Mabel ^a,b   Eckhardt, Laurel A ^a,c  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b ANTECH DIAGNOSTICS   (United States)

^c Department of Biological Sciences ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOB1 PROTEIN; DNA BINDING PROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN J CHAIN; OCTAMER TRANSCRIPTION FACTOR OTF 2; OCTAMER TRANSCRIPTION FACTOR OTF-2; ONCOPROTEIN; PROTO ONCOGENE PROTEIN SPI 1; PROTO-ONCOGENE PROTEIN SPI-1; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BETAHERPESVIRINAE; BIOSYNTHESIS; CELL CLONE; CELL FUNCTION; CELL FUSION; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; HUMAN; HYBRID CELL; HYBRIDOMA; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN J CHAIN GENE; IMMUNOGLOBULIN PRODUCTION; IMMUNOGLOBULIN SECRETING CELL; IMMUNOLOGY; METABOLISM; MOUSE; MOUSE MUTANT; MOUSE STRAIN; NONHUMAN; NUTRITIONAL DEFICIENCY; PHENOTYPE; PHYSIOLOGY; PLASMACYTOMA; PRIORITY JOURNAL; T CELL LYMPHOMA; T LYMPHOCYTE; TRANSCRIPTION FACTOR OCA B GENE; TRANSCRIPTION FACTOR OCT 2 GENE; TRANSCRIPTION FACTOR PU.1 GENE; TRANSGENE; TUMOR CELL LINE;

EID: 0345735828     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.12.6589     Document Type: Article

References (51)

1. Staudt, L. M., R. G. Clerc, H. Singh, J. H. LeBowitz, P. A. Sharp, and D. Baltimore. 1988. Cloning of a lymphoid-specific cDNA encoding a protein binding the regulating octamer DNA motif. Science 241:577.
2. Strubin, M., J. W. Newell, and P. Matthias. 1995. OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. Cell 80:497.
3. Luo, Y., H. Fujii, T. Gerster, and R. G. Roeder. 1992. A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors. Cell 71:231.
4. Gstaiger, M., L. Knoepfel, O. Georgiev, W. Schaffner, and C. M. Hovens. 1995. A B-cell coactivator of octamer-binding transcription factors. Nature 373:360.
5. Klemsz, M. J., S. R. McKercher, A. Celada, C. VanBeveren, and R. A. Maki. 1990. The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell 61:113.
6. Cockerill, P. N., and S. P. Klinken. 1990. Octamer-binding proteins in diverse hemopoietic cells. Mol. Cell. Biol. 10:1293.
7. Nelsen, B., G. Tian, B. Erman, J. Gregoire, R. Maki, B. Graves, and R. Sen. 1993. Regulation of lymphoid-specific immunoglobulin μ heavy chain gene enhancer by ETS-domain proteins. Science 261:82.
8. Scott, E. W., M. C. Simon, J. Anastasi, and H. Singh. 1994. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265:1573.
9. McKercher, S. R., B. E. Torbett, K. L. Anderson, G. W. Henkel, D. J. Vestal, H. Baribault, M. Klemsz, A. J. Feeney, G. E. Wu, C. J. Paige, et al. 1996. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 15:5647.
10. Corcoran, L. M., M. Karvelas, G. J. Nossal, Z. S. Ye, T. Jacks, and D. Baltimore. 1993. Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. Genes Dev. 7:570.
11. Schubart, D. B., A. Rolink, M. H. Kosco-Vilbois, F. Botteri, and P. Matthias. 1996. B-cell-specific coactivator OBF-1/OCA-B/Bob-1 required for immune response and germinal centre formation. Nature 383:538.
12. Kim, U., X. F. Qin, S. Gong, S. S., Y. Luo, M. Nussenzweig, and R. G. Roeder. 1996. The B-cell-specific transcriptional coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes. Nature 383:542.
13. Schubart, K., M. Steffen, D. Schubart, L. M. Corcoran, A. G. Rolink, and P. Matthias. 2001. B cell development and immunoglobulin gene transcription in the absence of Oct-2 and OBF-1. Nat. Immunol. 2:69.
14. Zaller, D. M., H. Yu, and L. A. Eckhardt. 1988. Genes activated in the presence of an immunoglobulin enhancer or promoter are negatively regulated by a T-lymphoma cell line. Mol. Cell. Biol. 8:1932.
15. Lieberman, S. A., M. D. Hines, P. L. Bergsagel, W. M. Kuehl, and L. A. Eckhardt. 1993. Coordinate silencing of myeloma-specific genes in myeloma × T lymphoma hybrids. J. Immunol. 151:2588.
16. Hines, M. D., H. S. Radomska, and L. A. Eckhardt. 1998. Transcription factor effects on chromosome constitution of cell hybrids. Cytogenet. Cell. Genet. 83:64.
17. Radomska, H. S., C. P. Shen, T. Kadesch, and L. A. Eckhardt. 1994. Constitutively expressed Oct-2 prevents immunoglobulin gene silencing in myeloma × T cell hybrids. Immunity 1:623.
18. Sharif, N., H. S. Radomska, D. M. Miller, and L. A. Eckhardt. 2001. Unique function for carboxyl-terminal domain of Oct-2 in Ig-secreting cells. J. Immunol. 167:4421.
19. Hyman, R., and V. Stallings. 1974. Complementation patterns of Thy-1 variants and evidence that antigen loss variants "pre-exist" in the parental population. J. Natl. Cancer Inst. 52:429.
20. Laskov, R., and M. D. Scharff. 1970. Synthesis assembly and secretion of γ globulin by mouse myeloma cells. I. Adoption of the MPC-11 tumor to culture, cloning and characterization of gamma globulin subunits. J. Exp. Med. 131:515.
21. Hartman, S. C., and R. C. Mulligan. 1988. Two dominant-acting selectable markers for gene transfer studies in mammalian cells. Proc. Natl. Acad. Sci. USA 85:8047.
22. Van Doren, K., D. Hanahan, and Y. Gluzman. 1984. Infection of eucaryotic cells by helper-independent recombinant adenoviruses: early region 1 is not obligatory for integration of viral DNA. J. Virol. 50:606.
23. Schubart, D., P. Sauter, S. Massa, E. Friedl, H. Schwarzenbach, and P. Matthias. 1996. Gene structure and characterization of the murine homologue of the B cell-specific transcriptional coactivator OBF-1. Nucleic Acids Res. 24:1913.
24. Karasuyama, H., and F. Melchers. 1988. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. Eur. J. Immunol. 18:97.
25. Nordeen, S. 1988. Luciferase reporter gene vectors for analysis of promoters and enhancers. BioTechniques 6:454.
26. Radomska, H. S., and L. A. Eckhardt. 1995. Mammalian cell fusion in an electroporation device. J. Immunol. Methods 188:209.
27. Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475.
28. Yu, H., B. Porton, L. Shen, and L. A. Eckhardt. 1989. Role of the octamer motif in hybrid cell extinction of immunoglobulin gene expression; extinction is dominant in a two enhancer system. Cell 58:441.
29. Maniatis, T., E. Fritsch, and J. Sambrook. 1989. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratories, Cold Spring Harbor.
30. Cann, G. M., A. Zaritsky, and M. E. Koshland. 1982. Primary structure of the immunoglobulin J chain from the mouse. Proc. Natl. Acad. Sci. USA 79:6656.
31. Zaller, D. M., and L. A. Eckhardt. 1985. Deletion of a B-cell-specific enhancer affects transfected, but not endogenous, immunoglobulin heavy-chain gene expression. Proc. Natl. Acad. Sci. USA 82:5088.
32. Simon, M. C. 1998. PU.1 and hematopoiesis: lessons learned from gene targeting experiments. Semin. Immunol. 10:111.
33. Scott, E. W., R. C. Fisher, M. C. Olson, E. W. Kehrli, M. C. Simon, and H. Singh. 1997. PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. Immunity 6:437.
34. Shin, M. K., and M. E. Koshland. 1993. Ets-related protein PU.1 regulates expression of the immunoglobulin J-chain gene through a novel Ets-binding element. Genes Dev. 7:2006.
35. Zhang, D.-E., C. Hetherington, H.-M. Chen, and D. Tenen. 1994. The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor. Mol. Cell. Biol. 14:373.
36. Chen, H., P. Zhang, H. Radomska, C. Hetherington, D. Zhanz, and D. Tenen. 1996. Octamer binding factors and their coactivator can activate the murine PU.1 promoter. J. Biol. Chem. 271:15743.
37. Luo, Y., and R. G. Roeder. 1995. Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. Mol. Cell. Biol. 15:4115.
38. Tjian, R., and M. Levine. 2003. Transcriptional regulation and animal diversity. Nature 424:147.
39. Stevens, S., J. Ong, U. Kim, L. A. Eckhardt, and R. G. Roeder. 2000. Role of OCA-B in 3′-IgH enhancer function. J. Immunol. 164:5306.
40. Tang, H., and P. A. Sharp. 1999. Transcriptional regulation of the murine 3′IgH enhancer by OCT-2. Immunity 11:517.
41. Stevens, S., L. Wang, and R. G. Roeder. 2000. Functional analysis of the OCA-B promoter. J. Immunol. 164:6372.
42. Schwering, I., A. Brauninger, U. Klein, B. Jungnickel, M. Tinguely, V. Diehl, M.-L. Hansmann, R. Dalla-Favera, K. Rajewsky, and R. Kuppers. 2003. Loss of the B lineage-specific gene expression program in Hodgkin and Reed/Sternberg cells of Hodgkin's lymphoma. Blood 101:1505.
43. Nielsen, P., O. Georgiev, B. Lorenz, and W. Schaffner. 1996. B lymphocytes are impaired in mice lacking the transcriptional co-activator Bob1/OCA-B/OBF1. Eur. J. Immunol. 26:3214.
44. Humbert, P. O., and L. M. Corcoran. 1997. Oct-2 gene disruption eliminates the peritoneal B-1 lymphocyte lineage and attenuates B-2 cell maturation and function. J. Immunol. 159:5237.
45. Hess, J., P. Nielsen, K. Fischer, H. Bujard, and T. Wirth. 2001. The B lymphocyte-specific coactivator BOB.1/OBF.1 is required at multiple stages of B cell development. Mol. Cell. Biol. 21:1531.
46. Samardzic, T., J. Gerlach, K. Muller, D. Marinkovic, J. Hess, L. Nitschke, and T. Wirth. 2002. CD22 regulates early B cell development in BOB.1/OBF.1-deficient mice. Eur. J. Immunol. 32:2481.
47. 1 progression and for proliferation. Immunity 1:635.
48. Qin, X. F., A. Reichlin, Y. Luo, R. G. Roeder, and M. C. Nussenzweig. 1998. OCA-B integrates B cell antigen receptor-, CD40L- and IL 4-mediated signals for the germinal center pathway of B cell development. EMBO J. 17:5066.
49. Kang, S. M., W. Tsang, S. Doll, P. Scherle, H. S. Ko, A. C. Tran, M. J. Lenardo, and L. M. Staudt. 1992. Induction of the POU domain transcription factor Oct-2 during T-cell activation by cognate antigen. Mol. Cell. Biol. 12:3149.
50. Sauter, P., and P. Matthias. 1997. The B cell-specific coactivator OBF-1 (OCA-B, Bob-1) is inducible in T cells and its expression is dispensable for IL-2 gene induction. Immunobiology 198:207.
51. Moriuchi, M., and H. Moriuchi. 2001. Octamer transcription factors up-regulate the expression of CCR5, a coreceptor for HIV-1 entry. J. Biol. Chem. 276:8639.