Axotomy abolishes NeuN expression in facial but not rubrospinal neurons

Experimental Neurology

Volumn 185, Issue 1, 2004, Pages 182-190

  McPhail, Lowell T ^a   McBride, Christopher B ^a   McGraw, John ^a   Steeves, John D ^a   Tetzlaff, Wolfram ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Axotomy; Crush; Facial motoneurons; Injury; NeuN; Rubrospinal neurons

Indexed keywords

ANTIBODY; MARKER; NEURONAL NUCLEI ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CERVICAL SPINAL CORD; CONTROLLED STUDY; FACIAL NERVE; IMMUNOREACTIVITY; MALE; MOTONEURON; MOUSE; NERVE CELL; NERVE CRUSH; NERVE FIBER TRANSECTION; NERVE SURGERY; NONHUMAN; PERIPHERAL NERVE; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RUBROSPINAL TRACT; WESTERN BLOTTING;

EID: 0345732566     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.expneurol.2003.10.001     Document Type: Article

References (13)

1. Fernandes K.J., Tetzlaff W. Gene expression in axotomized neurons: identifying the intrinsic determinants of axonal growth. Ingoglia N.A., Murray M. Axonal regeneration in the central nervous system. 2000;219-266 Marcel Dekker, New York.
2. Fernandes K.J., Fan D.P., Tsui B.J., Cassar S.L., Tetzlaff W. Influence of the axotomy to cell body distance in rat rubrospinal and spinal motoneurons: differential regulation of GAP-43, tubulins, and neurofilament-M. J. Comp. Neurol. 414:1999;495-510.
3. Ferri C.C., Moore F.A., Bisby M.A. Effects of facial nerve injury on mouse motoneurons lacking the p75 low-affinity neurotrophin receptor. J. Neurobiol. 34:1998;1-9.
4. Houle J.D., Ye J.H. Survival of chronically-injured neurons can be prolonged by treatment with neurotrophic factors. Neuroscience. 94:1999;929-936.
5. Jongen-Relo A.L., Feldon J. Specific neuronal protein: a new tool for histological evaluation of excitotoxic lesions. Physiol. Behav. 76:2002;449-456.
6. Kobayashi N.R., Fan D.P., Giehl K.M., Bedard A.M., Wiegand S.J., Tetzlaff W. BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate Gap-43 and T-alpha-1-tubulin mRNA expression, and promote axonal regeneration. J. Neurosci. 17:1997;9583-9595.
7. Kwon B.K., Liu J., Messerer C., Kobayashi N.R., McGraw J., Oschipok L., Tetzlaff W. Survival and regeneration of rubrospinal neurons 1 year after spinal cord injury. Proc. Natl. Acad. Sci. U. S. A. 99:2002;3246-3251.
8. Kwon B.K., Liu J., Oschipok L., Tetzlaff W. Reaxotomy of chronically injured rubrospinal neurons results in only modest cell loss. Exp. Neurol. 177:2002;332-337.
9. Miller F.D., Tetzlaff W., Bisby M.A., Fawcett J.W., Milner R.J. Rapid induction of the major embryonic alpha-tubulin mRNA, T alpha 1, during nerve regeneration in adult rats. J. Neurosci. 9:1989;1452-1463.
10. Mori F., Himes B.T., Kowada M., Murray M., Tessler A. Fetal spinal cord transplants rescue some axotomized rubrospinal neurons from retrograde cell death in adult rats. Exp. Neurol. 143:1997;45-60.
11. Mullen R.J., Buck C.R., Smith A.M. NeuN, a neuronal specific nuclear protein in vertebrates. Development. 116:1992;201-211.
12. Naumann T., Kermer P., Frotscher M. Fine structure of rat septohippocampal neurons. III. Recovery of choline acetyltransferase immunoreactivity after fimbria-fornix transection. J. Comp. Neurol. 350:1994;161-170.
13. Tetzlaff W., Alexander S.W., Miller F.D., Bisby M.A. Response of facial and rubrospinal neurons to axotomy: changes in mRNA expression for cytoskeletal proteins and GAP-43. J. Neurosci. 11:1991;2528-2544.