The Global Transcriptional Activator of Saccharomyces cerevisiae, Gcr1p, Mediates the Response to Glucose by Stimulating Protein Synthesis and CLN-Dependent Cell Cycle Progression

Genetics

Volumn 165, Issue 3, 2003, Pages 1017-1029

  Willis, Kristine A ^a   Barbara, Kellie E ^a   Menon, Balaraj B ^a   Moffat, Jason ^b   Andrews, Brenda ^b   Santangelo, George M ^a  

^a The University of Southern Mississippi   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GLUCOSE; PHOSPHOPROTEIN; PHOSPHOPROTEIN GCR1P; RIBOSOME PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL METABOLISM; DNA CONTENT; GENETIC TRANSCRIPTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SACCHAROMYCES CEREVISIAE;

BASE SEQUENCE; CELL CYCLE; CYCLINS; DNA PRIMERS; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GLUCOSE; MUTATION; PROTEIN BIOSYNTHESIS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0345730825     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. AMON, A., S. IRNIGER and K. NASMYTH, 1994 Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle. Cell 77: 1037-1050.
2. ANTHONY, C., Q. ZONG and A. DE BENEDETTI, 2001 Overexpression of c1F4E in Saccharomyces cerevisiae causes slow growth and decreased alpha-factor response through alterations in CLN3 expression. J. Biol. Chem. 276: 39645-39652.
3. ASHE, M. P., J. W. SLAVKN, S. K. DE LONG, S. IBRAHIMO and A. B. SACHS, 2001 A novel eIF2B-dependent mechanism of translational control in yeast as a response to fusel alcohols. EMBO J. 20: 6464-6474.
4. BARONI, M. D., P. MONTI and L. ALBERGHINA, 1994 Repression of growth-regulated G1 cyclin expression by cyclic AMP in budding yeast. Nature 371: 339-342.
5. BENTON, B. K., A. H. TINKELENBERG, D. JEAN, S. D. PLUMP and F. R. CROSS, 1993 Genetic analysis of Cln/Cdc28 regulation of cell morphogenesis in budding yeast. EMBO J. 12: 5267-5275.
6. BONY, M., P. BARRE and B. BLONDIN, 1998 Distribution of the flocculation protein, flop, at the cell surface during yeast growth: the availability of flop determines the flocculation level. Yeast 14: 25-35.
7. BURKE, D. J., and D. CHURCH, 1991 Protein synthesis requirements for nuclear division, cytokinesis, and cell separation in Saccharomyces cerevisiae. Mol. Cell. Biol. 11: 3691-3698.
8. CROSS, F. R., 1988 DAF1, a mutant gene affecting sine control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae. Mol. Cell. Biol. 8: 4675-4684.
9. CULLEN, P. J., and G. F. SPRAGUE, 2000 Glucose depletion causes haploid invasive growth in yeast. Proc. Natl. Acad. Sci. USA 97: 13619-13624.
10. CVRCKOVA, F., and K. NASMYTH, 1993 Yeast G1 cyclins CLN1 and CLN2 and a GAP-like protein have a role in bud formation. EMBO J. 12: 5277-5286.
11. CVRCKOVA, F., C. DE VIRGILIO, E. MANSER, J. R. PRINGLE and K. NASMYTH, 1995 Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Genes Dev. 9: 1817-1830.
12. DANAIE, P., M. ALTMANN, M. N. HALL, H. TRACHSEL and S. B. HELLIWELL, 1999 CLN3 overexpression is sufficient to restore G1 to S phase progression in Saccharomyces cerevisiae mutants defective in translation initiation factor eIF4E. Biochem. J. 340: 135-141.
13. DEMINOFF, S. J., and G. M. SANTANGELO, 2001 Rap1p requires Gcr1p and Gcr2p homodimers to activate ribosomal protein and glycolytic genes, respectively. Genetics 158: 133-143.
14. DEMINOFF, S. J., J. TORNOW and G. M. SANTANGELO, 1995 Unigenic evolution: a novel genetic method localizes a putative leucine zipper that mediates dimerization of the Saccharomyces cerevisiae regulatory Gcr1p. Genetics 141: 1263-1274.
15. DEMINOFF, S. J., K. WILLIS and G. M. SANTANGELO, 2003 Coordination between eukaryotic growth and cell cycle progression: RAP1/GCR1 transcriptional activation mediates glucose-dependent CLN function. Recent Res. Dev. Genet. 3: 1-16.
16. DIRICK, L., T. BOHM and K. NASMYTH, 1995 Roles and regulation of Cln-Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae. EMBO J. 14: 4803-4813.
17. GALLEGO, C., E. GARI, N. COLOMINA, E. HERRERO and M. ALDEA, 1997 The Cln3 cyclin is down-regulated by translational repression and degradation during the G1 arrest caused by nitrogen deprivation in budding yeast. EMBO J. 16: 7196-7206.
18. HALL, D. D., D. D. MARKWARDT, F. PARVIZ and W. HEIDEMAN, 1998 Regulation of the Cln3-Cdc28 kinase by cAMP in Sacchoromyces cerevisiae. EMBO J. 17: 4370-4376.
19. KOBAYASHI, O., H. YOSHIMOTO and H. SONE, 1999 Analysis of the genes activated by the FLO8 gene in Saccharomyces cerevisiae. Curr. Genet. 36: 256-261.
20. LAROCHE, T., S. G. MARTIN, M. TSAI-PFLUGFELDER and S. M. GASSER, 2000 The dynamics of yeast telomeres and silencing proteins through the cell cycle. J. Struct. Biol. 129: 159-174.
21. LENBURG, M. E., and E. K. O'SHEA, 2001 Genetic evidence for a morphogenetic function of the Saccharomyces cerevisiae Pho85 cyclin-dependent kinase. Genetics 157: 39-51.
22. LEW, D.J., T. WEINERT and J. R. PRINGLE, 1997 Cell cycle control in Saccharomyces cerevisiae, pp. 607-695 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Cell Cycle and Cell Biology, edited by J. R. PRINGLE, J. R. BROACH and E. W. JONES. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
23. LINSKENS, M., M. TYERS and B. FUTCHER, 1993 CLN3 functions in both daughter and mother cells of S. cerevisiae. Cell 72: 47-48.
24. LIU, H., C. A. STYLES and G. R. FINK, 1996 Saccharomyces cerevisiae S288C has a mutation in FLO8, a gene required for filamentous growth. Genetics 144: 967-978.
25. MACKAY, V. L., B. MAI, L. WATERS and L. L. BREEDEN, 2001 Early cell cycle box-mediated transcription of CLN3 and SWI4 contributes to the proper timing of the G1 to S transition in budding yeast. Mol. Cell. Biol. 21: 4140-4148.
26. MASY, C. L., A. HENQUINET and M. M. MESTDAGH, 1992 Flocculation of Saccharomyces cerevisiae, inhibition by sugars. Can. J. Microbiol. 38: 1298-1306.
27. MEASDAY, V., L. MOORE, J. OGAS, M. TYERS and B. ANDREWS, 1994 The PCL2 (ORFD)-PHO85 cyclin-dependent kinase complex: a cell cycle regulator in yeast. Science 266: 1391-1395.
28. MEASDAY, V., L. MOORE, R. RETNAKARAN, J. LEE, M. DENOVIEL et al., 1997 A family of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase. Mol. Cell. Biol. 17: 1212-1223.
29. MENCIA, M., Z. MOQTADERI, J. V. GEISBERG, L. KURAS and K. STRUHL, 2002 Activator-specific recruitment of TFIID and regulation of ribosomal protein genes in yeast. Mol. Cell 9: 823-833.
30. MOORE, S. A., 1988 Kinetic evidence for a critical rate of protein synthesis in the Saccharomyces cerevisiae yeast cell cycle. J. Biol. Chem. 263: 9674-9681.
31. NASMYTH, K., and L. DIRICK, 1991 The role of SWI4 and SWI6 in the activity of G1 cyclins in yeast. Cell 66: 995-1013.
32. OGAS, J., B. J. ANDREWS and I. HERSKOWITZ, 1991 Transcriptional activation of CLN1, CLN2, and a putative new G1 cyclin (HCS26) by SWI4, a positive regulator of G1-specific transcription. Cell 66: 1015-1026.
33. PALECEK, S. P., A. S. PARIKH and S. J. KRON, 2000 Genetic analysis reveals that FLO11 upregulation and cell polarization independently regulate invasive growth in Saccharomyces cerevisiae. Genetics 156: 1005-1023.
34. PARVIZ, F., and W. HEIDEMAN, 1998 Growth-independent regulation of CLN3 mRNA levels by nutrients in Saccharomyces cerevisiae. J. Bacteriol. 180: 225-230.
35. POLAKIS, E. S., and W. BARTLEY, 1966 Changes in the enzyme activities of Saccharomyces cerevisiae during aerobic growth on different carbon sources. Biochem. J. 97: 284-297.
36. POLYMENIS, M., and E. V. SCHMIDT, 1997 Coupling of cell division to cell growth by translational control of the G1 cyclin CLN3 in yeast. Genes Dev. 11: 2522-2531.
37. POPOLO, L., M. VANONI and L. ALBERGHINA, 1982 Control of the yeast cell cycle by protein synthesis. Exp. Cell Res. 142: 69-78.
38. PRINGLE, J. R., and L. H. HARTWELL, 1981 The Saccharomyces cerevisiae cell cycle, pp. 97-142 in The Molecular Biology of the Yeast Saccharomyces: Life Cycle and Inheritance, edited by J. N. STRATHERN, E. W. JONES and J. R. BROACH. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
39. SANTANGELO, G. M., and J. TORNOW, 1990 Efficient transcription of the glycolylic gene ADH1 and three translational component genes requires the GCR1 product, which can act through TUF/GRF/RAP binding sites. Mol. Cell. Biol. 10: 859-862.
40. SHEDDEN, K., and S. COOPER, 2002 Analysis of cell-cycle gene expression in Saccharomyces cerevisiae using microarrays and multiple synchronization methods. Nucleic Acids Res, 30: 2920-2929.
41. SHEN, W. C., and M. R. GREEN, 1997 Yeast TAF(II)145 functions as a core promoter selectivity factor, not a general coactivator. Cell 90: 615-624.
42. SHERMAN, F., G. R. FINK and J. B. HICKS, 1986 Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
43. SOARES, E. V., and M. MOTA, 1996 Flocculation onset, growth phase, and genealogical age in Saccharomyces cerevisiae. Can. J. Microbiol. 42: 539-547.
44. SPELLMAN, P. T., G. SHERLOCK, M. Q. ZHANG, V. R. IYER, K. ANDERS et al., 1998 Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Mol. Biol. Cell 9: 3272-3297.
45. STUART, D., and C. WITTENBERG, 1995 CLN3, not positive feedback, determines the timing of CLN2 transcription in cycling cells, Genes Dev. 15: 2780-2794.
46. TENNYSON, C. N., J. LEE and B. J. ANDREWS, 1998 A role for the Pcl9-Pho85 cyclin-cdk complex at the M/G1 boundary in Saccharomyces cerevisiae. Mol. Microbiol. 28: 69-79.
47. TORNOW, J., X. ZENG, W. GAO and G. M. SANTANGELO, 1993 GCR1, a transcriptional activator in Saccharomyces cerevisiae, complexes with RAP1 and can function without its DNA binding domain. EMBO J. 12: 2431-2437.
48. TYERS, M., G. TOKIWA and B. FUTCHER, 1993 Comparison of the Saccharomyces cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins. EMBO J. 12: 1955-1968.
49. VELCULESCO, V. E., L. ZHANG, W. ZHOU, J. VOGELSTEIN, M. A. BASRAI et al., 1997 Characterization of the yeast transcriptome. Cell 88: 243-251.
50. ZENG, X., S. J. DEMINOFF and G. M. SANTANGELO, 1997 Specialized Rap1p/Gcr1p transcriptional activation through Gcr1p DNA contacts requires Gcr2p, as does hyperphosphorylation of Gcr1p. Genetics 147: 493-505.