3,4-DAP-evoked transmitter release in hippocampal slices of aged rats with impaired memory

Brain Research Bulletin

Volumn 62, Issue 2, 2003, Pages 129-136

  Schweizer, Theresa ^a   Birthelmer, Anja ^a   Lazaris, Anelise ^b   Cassel, Jean Christophe ^a,b   Jackisch, Rolf ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b Centre de Neurochimie   (France)

Author keywords

Acetylcholine; Aging; Hippocampus; Noradrenaline; Serotonin; Water maze

Indexed keywords

3,4 DIAMINOPYRIDINE; ACETYLCHOLINE; NICOTINIC RECEPTOR; NORADRENALIN; POTASSIUM CHANNEL BLOCKING AGENT; PRESYNAPTIC RECEPTOR; SEROTONIN;

ACETYLCHOLINE RELEASE; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; COGNITIVE DEFECT; CONTROLLED STUDY; CORRELATION ANALYSIS; EVOKED RESPONSE; FEMALE; HIPPOCAMPUS; MAZE TEST; MEMORY DISORDER; MENTAL TASK; NERVE CELL EXCITABILITY; NEUROPATHOLOGY; NEUROTRANSMITTER RELEASE; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; RAT; SEROTONIN RELEASE;

EID: 0345724851     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2003.09.003     Document Type: Article

References (25)

1. Bangalore R., Triggle D.J. Age-dependent changes in voltage-gated calcium channels and ATP-dependent potassium channels in Fischer 344 rats. Gen. Pharmacol. 26:1995;1237-1242.
2. Bartus R.T. On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp. Neurol. 163:2000;495-529.
3. Baxter M.G., Chiba A.A. Cognitive functions of the basal forebrain. Curr. Opin. Neurobiol. 9:1999;178-183.
4. Birthelmer A., Ehret A., Amtage F., Forster S., Lehmann O., Jeltsch H., Cassel J.C., Jackisch R. Neurotransmitter release and its presynaptic modulation in the rat hippocampus after selective damage to cholinergic or/and serotonergic afferents. Brain Res. Bull. 59:2003;371-381.
5. Birthelmer A., Stemmelin J., Jackisch R., Cassel J.C. Presynaptic modulation of acetylcholine, noradrenaline, and serotonin release in the hippocampus of aged rats with various levels of memory impairments. Brain Res. Bull. 60:2003;283-296.
6. Cassel J.C., Jeltsch H. Serotonergic modulation of cholinergic function in the central nervous system: cognitive implications. Neuroscience. 69:1995;1-41.
7. 3H ]hemicholinium binding to high-affinity choline uptake sites in aged rat brain Brain Res. 570:1992;354-357.
8. Gallagher M., Burwell R.D. Relationship of age-related decline across several behavioral domains. Neurobiol. Aging. 10:1989;691-708.
9. Ghirardi O., Giuliani A., Caprioli A., Ramacci M.T., Angelucci L. Spatial memory in aged rats: population heterogeneity and effect of levocarnitine acetyl. J. Neurosci. Res. 31:1992;375-379.
10. Ingram D.K., Spangler E.L., Iijima S., Ikari H., Kuo H., Greig N.H., London E.D. Rodent models of memory dysfunction in Alzheimer's disease and normal aging: moving beyond the cholinergic hypothesis. Life Sci. 55:1994;2037-2049.
11. Kiss T., Laszlo Z., Szabadics J. Mechanism of 4-aminopyridine block of the transient outward K-current in identified Helix neuron. Brain Res. 927:2002;168-179.
12. Lauth D., Hertting G., Jackisch R. 3,4-Diaminopyridine-evoked noradrenaline release in rat hippocampal slices: facilitation by endogenous or exogenous nitric oxide. Brain Res. 692:1995;174-182.
13. Lindner M.D. Reliability, distribution, and validity of age-related cognitive deficits in the Morris water maze. Neurobiol. Learn. Mem. 68:1997;203-220.
14. McMahon H.T., Nicholls D.G. The bioenergetics of neurotransmitter release. Biochim. Biophys. Acta. 1059:1991;243-264.
15. Meyer E.M., Crews F.T., Otero D.H., Larsen K. Aging decreases the sensitivity of rat cortical synaptosomes to calcium ionophore-induced acetylcholine release. J. Neurochem. 47:1986;1244-1246.
16. Sarter M., Bruno J.P., Turchi J. Basal forebrain afferent projections modulating cortical acetylcholine, attention, and implications for neuropsychiatric disorders. Ann. N.Y. Acad. Sci. 877:1999;368-382.
17. Schweizer T., Birthelmer A., Jeltsch H., Cassel J.C., Jackisch R. Raphe grafts, and 3,4-diaminopyridine-evoked overflow of serotonin in the rat hippocampus after 5,7-dihydroxytryptamine lesions: evidence for 5-HT1A autoreceptors. Neuroreport. 13:2002;1871-1874.
18. Shores M.M., White S.S., Veith R.C., Szot P. Tyrosine hydroxylase mRNA is increased in old age and norepinephrine uptake transporter mRNA is decreased in middle age in locus coeruleus of Brown-Norway rats. Brain Res. 826:1999;143-147.
19. Stemmelin J., Cassel J.C., Will B., Kelche C. Sensitivity to cholinergic drug treatments of aged rats with variable degrees of spatial memory impairment. Behav. Brain Res. 98:1999;53-66.
20. Stemmelin J., Lazarus C., Cassel S., Kelche C., Cassel J.C. Immunohistochemical and neurochemical correlates of learning deficits in aged rats. Neuroscience. 96:2000;275-289.
21. Suhr R., Balse E., Haaf A., Kelche C., Cassel J.C., Jackisch R. Modulation of acetylcholine and 5-hydroxytryptamine release in hippocampal slices of rats with fimbria-fornix lesions and intrahippocampal grafts containing cholinergic and/or serotonergic neurons. Brain Res. Bull. 50:1999;15-25.
22. Tanaka Y., Hasegawa A., Ando S. Impaired synaptic functions with aging as characterized by decreased calcium influx and acetylcholine release. J. Neurosci. Res. 43:1996;63-76.
23. van der Staay F.J., de Jonge M. Effects of age on water escape behavior and on repeated acquisition in rats. Behav. Neural Biol. 60:1993;33-41.
24. Vizi E.S., Kiss J.P. Neurochemistry and pharmacology of the major hippocampal transmitter systems: synaptic and nonsynaptic interactions. Hippocampus. 8:1998;566-607.
25. Zsilla G., Zelles T., Mike A., Kekes-Szabo A., Milusheva E., Vizi E.S. Differential changes in presynaptic modulation of transmitter release during aging. Int. J. Dev. Neurosci. 12:1994;107-115.