Antiviral Therapy in Children with Varicella Zoster Virus and Herpes Simplex Virus Infections

Herpes

Volumn 10, Issue 2, 2003, Pages 32-37

  Enright, Andrea M ^a   Prober, Charles ^a  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Chickenpox; Gingivostomatitis; Healthy children; Herpes simplex virus type 1 (HSV 1) and type 2 (HSV 2); Immuno compromised children; Mucocutaneous HSV infection; Newborns; Shingles; Varicella zoster virus (VZV); Zoster

Indexed keywords

ACICLOVIR; ANTIVIRUS AGENT; AZATHIOPRINE; CD4 ANTIGEN; CELL ENZYME; CIDOFOVIR; CORTICOSTEROID; CYCLOSPORIN; DNA POLYMERASE; DRUG METABOLITE; FAMCICLOVIR; FOSCARNET; GUANOSINE DERIVATIVE; NUCLEOSIDE ANALOG; PENCICLOVIR; PLACEBO; PROBENECID; PRODRUG; PYROPHOSPHORIC ACID DERIVATIVE; SALICYLIC ACID; THYMIDINE KINASE; VALACICLOVIR; VIDARABINE;

CHICKENPOX; CLINICAL FEATURE; CLINICAL PROTOCOL; CLINICAL TRIAL; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; DISEASE SEVERITY; DNA SYNTHESIS INHIBITION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CHOICE; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG HALF LIFE; DRUG INDICATION; DRUG MECHANISM; DRUG MEGADOSE; DRUG TOXICITY; ENZYME INHIBITION; HERPES SIMPLEX; HERPES SIMPLEX VIRUS; HERPES ZOSTER; HIGH RISK PATIENT; HUMAN; IMMUNE DEFICIENCY; IMMUNE RESPONSE; INFECTION RISK; LYMPHOCYTE COUNT; NEPHROTOXICITY; NEUTROPENIA; OUTCOMES RESEARCH; PATIENT COMPLIANCE; PHARMACOKINETICS; PHOSPHORYLATION; POSTHERPETIC NEURALGIA; PRESCRIPTION; PRIORITY JOURNAL; RECURRENT INFECTION; REVIEW; SYMPTOM; VARICELLA ZOSTER VIRUS; VIRUS ISOLATION; VIRUS LATENCY; VIRUS REPLICATION; VIRUS TRANSMISSION;

ANTIVIRAL AGENTS; CHICKENPOX; CHILD; CHILD, PRESCHOOL; DRUG APPROVAL; HERPES SIMPLEX; HUMANS; INFANT; INFANT, NEWBORN; RANDOMIZED CONTROLLED TRIALS; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 3; SIMPLEXVIRUS;

EID: 0345724848     PISSN: 09697667     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (99)

1. Kimberlin DW, Prober CG. Antiviral Agents in Principles and Practice of Pediatric Infectious Diseases, 2nd edn. New York: Churchill Livingstone, 2003;pp1527-1546.
2. Waugh SM, Pillay D, Carrington D, Carman WF. Antiviral prophylaxis and treatment (excluding HIV therapy). J Clin Virol 2002;25:241-266.
3. Oram RJ, Marcellino D, Strauss D, Gustafson E, Talarico CL, Root AK et al. Characterization of an acyclovir-resistant herpes simplex virus type 2 strain isolated from a premature neonate. J Infect Dis 2000;181:1458-1461.
4. Morfin F, Thouvenot D, De Turenne-Tessier M, Lina B, Aymard M, Ooka T. Phenotypic and genetic characterization of thymidine kinase from clinical strains of varicella-zoster virus resistant to acyclovir. Antimicrob Agents and Chemother 1999;43:2412-2416.
5. Breton G, Fillet AM, Katlama C, Bricaire F, Caumes E. Acyclovir-resistant herpes zoster in human immunodeficiency virus-infected patients: results of foscarnet therapy. Clin Infect Dis 1998;27:1525-1527.
6. Saint-Leger E, Caumes E, Breton G, Douard D, Saiag P, Huraux JM et al. Clinical and virologic characterization of acyclovir-resistant varicella-zoster viruses isolated from 11 patients with acquired immunodeficiency syndrome. Clin Infect Dis 2001;33:2061-2067.
7. Ida M, Kageyama S, Sato H, Kamiyama T, Yamamura J, Kurokawa M et al. Emergence of resistance to acyclovir and penciclovir in varicella-zoster virus and genetic analysis of acyclovir-resistant variants. Antiviral Res 1999;40:155-166.
8. Pahwa S, Biron K, Lim W, Swenson P, Kaplan MH, Sadick N et al. Continuous varicella-zoster infection associated with acyclovir resistance in a child with AIDS. JAMA 1988;260:2879-2882.
9. Jacobson MA. Valaciclovir (BW256U87): the L-valyl ester of acyclovir. J Med Viral 1993;Suppl 1:150-153.
10. Soul-Lawton J, Seaber E, On N, Wootton R, Rolan P, Posner J. Absolute bioavailability and metabolic disposition of valaciclovir, the L-valyl ester of acyclovir, following oral administration to humans. Antimicrob Agents Chemother 1995;39:2759-2764.
11. Nadal D, Leverger G, Sokal EM, Floret D, Perel Y, Leibundgut K et al. An investigation of the steady-state pharmacokinetics of oral valacyclovir in immunocompromised children. J Infect Dis 2002;186(Suppl 1): S123-130.
12. Arvin AM. Oral therapy with acyclovir in infants and children. Pediatr Infect Dis J 1987;6:56-58.
13. Crumpacker C. The pharmacological profile of famciclovir. Semin Dermatol 1996;15(2 Suppl 1):14-26.
14. Jacobson MA, Berger TG, Fikrig S, Becherer P, Moohr JW, Stanat SC et al. Acyclovir-resistant varicella zoster virus infection after chronic oral acyclovir therapy in patients with the acquired immunodeficiency syndrome (AIDS). Ann Intern Med 1990;112:187-191.
15. Safrin S, Berger TG, Gilson I, Wolfe PR, Wofsy CB, Mills J et al. Foscarnet therapy in five patients with AIDS and acyclovir-resistant varicella-zoster virus infection. Ann Intern Med 1991;115:19-21.
16. Dunkle LM, Arvin AM, Whitley RJ, Rotbart HA, Feder HM, Jr, Feldman S et al. A controlled trial of acyclovir for chickenpox in normal children. N Engl J Med 1991;325:1539-1544.
17. Balfour HH, Jr, Rotbart HA, Feldman S, Dunkle LM, Feder HM Jr, Prober CG et al. Acyclovir treatment of varicella in otherwise healthy adolescents. The Collaborative Acyclovir Varicella Study Group. J Pediatr 1992;120:627-633.
18. Balfour HH, Jr, Kelly JM, Suarez CS, Heussner RC, Englund JA, Crane DD et al. Acyclovir treatment of varicella in otherwise healthy children. J Pediatr 1990;116:633-639.
19. Balfour HH, Jr, Edelman CK, Anderson RS, Reed NV, Slivken RM, Marmor LH et al. Controlled trial of acyclovir for chickenpox evaluating time of initiation and duration of therapy and viral resistance. Pediatr Infect Dis J 2001;20:919-926.
20. Klassen TP, Belseck EM, Wiebe N, Hartling L. Acyclovir for treating varicella in otherwise healthy children and adolescents (Cochrane Review). Cochrane Database Syst Rev 2002; CD002980.
21. American Academy of Pediatrics Committee on Infectious Diseases. The use of oral acyclovir in otherwise healthy children with varicella. Pediatrics 1993;91:674-676.
22. American Academy of Pediatrics. Varicella zoster infections. In: 2003 Red Book: Report of the Committee on Infectious Diseases, 26th edn. (Pickering LK, ed). Elk Grove Village, IL: American Academy of Pediatrics, 2003; pp672-686.
23. Ogilvie MM. Antiviral prophylaxis and treatment in chickenpox. A review prepared for the UK Advisory Group on Chickenpox on behalf of the British Society for the Study of Infection. J Infect 1998;36(Suppl 1): 31-38.
24. Tarlow MJ, Walters S. Chickenpox in childhood. A review prepared for the UK Advisory Group on Chickenpox on behalf of the British Society for the Study of Infection. J Infect 1998;36 (Suppl 1):39-47.
25. Manfredi R, Chiodo F. Aciclovir therapy for immunocompetent children with chickenpox. Clin Infect Dis 1997;24:1261-1262.
26. Wallace MR, Bowler WA, Murray NB, Brodine SK, Oldfield EC 3rd. Treatment of adult varicella with oral acyclovir. A randomized, placebo-controlled trial. Ann Intern Med 1992;117:358-363.
27. Clover RD. Acyclovir in chickenpox. N Engl J Med 1992;326:1224; author reply 1225-1226.
28. Smith CG, Glaser DA. Herpes zoster in childhood: case report and review of the literature. Pediatr Dermotol 1996;13:226-229.
29. Elmer KB, George RM. Herpes zoster in a 7-month-old infant: a case report and review. Cutis 1999;63:217-218.
30. Guess HA, Broughton DD, Melton LJ 3rd, Kurland LT. Epidemiology of herpes zoster in children and adolescents: a population-based study. Pediatrics 1985;76:512-517.
31. Wurzel CL, Kahan I, Heitler M, Rubin LG. Prognosis of herpes zoster in healthy children. Am J Dis Child 1986;140:477-478.
32. Rothe MJ, Feder HM, Jr, Grant-Kels JM. Oral acyclovir therapy for varicella and zoster infections in pediatric and pregnant patients: a brief review. Pediatr Dermatol 1991;8:236-242, 246-247.
33. Wood MJ, Johnson RW, McKendrick MW, Taylor J, Mandal BK, Crooks J. A randomized trial of acyclovir for 7 days or 21 days with and without prednisolone for treatment of acute herpes zoster. N Engl J Med 1994;330:896-900.
34. Wood MJ, Kay R, Dworkin RH, Soong SJ, Whitley RJ. Oral acyclovir therapy accelerates pain resolution in patients with herpes zoster: a meta-analysis of placebo-controlled trials. Clin Infect Dis 1996;22:341-347.
35. Wood MJ, Ogan PH, McKendrick MW, Care CD, McGill JI, Webb EM. Efficacy of oral acyclovir treatment of acute herpes zoster. Am J Med 1988;115:79-83.
36. Beutner KR, Friedman DJ, Forszpaniak C, Andersen PL, Wood MJ. Valaciclovir compared with acyclovir for improved therapy for herpes zoster in immunocompetent adults. Antimicrob Agents Chemother 1995;39:1546-1553.
37. Tyring S, Barbarash RA, Nahlik JE, Cunningham A, Marley J, Heng M et al. Famciclovir for the treatment of acute herpes zostee: effects on acute disease and postherpetic neuralgia. A randomized, double-blind, placebo-controlled trial. Collaborative Famciclovir Herpes Zoster Study Group. Ann Intern Med 1995;123:89-96.
38. American Academy of Pediatrics. Varicella zoster infections. In: 2003 Red Book: Report of the Committee on Infectious Diseases, 26th edn (Pickering LK, ed). Elk Grove, IL: American Academy of Pediatrics, 2003;pp678-680.
39. Prober CG, Gershon AA, Grose C, McCracken GH, Jr, Nelson JD. Consensus: varicella-zoster infections in pregnancy and the perinatal period. Pediatr Infect Dis J 1990;9:865-869.
40. King SM, Gorensek M, Ford-Jones EL, Read SE. Fatal varicella-zoster infection in a newborn treated with varicella-zoster immunoglobulin. Pediatr Infect Dis 1986;5:588-589.
41. Kavaliotis J. Acyclovir therapy in neonates. J Pediatr 1992;120:665.
42. Williams H, Latif A, Morgan J, Ansari BM. Acyclovir in the treatment of neonatal varicella. J Infect 1987;15:65-67.
43. Arvin AM. Varicella zoster virus. In: Principles and Practice of Pediatric Infectious Diseases, 2nd edn (Long SS, Pickering LK, Prober CG, eds). New York: Churchill Livingstone, 2003; pp1041-1049.
44. Englund JA, Fletcher CV, Balfour HH, Jr. Acyclovir therapy in neonates. J Pediatr 1991;119:129-135.
45. Whitley RJ, Soong SJ, Dolin R, Betts R, Linnemann C, Jr, Alford CA Jr. Early vidarabine therapy to control the complications of herpes zoster in immunosuppressed patients. N Engl J Med 1982;307:971-975.
46. Prober CG, Kirk LE, Keeney RE. Acyclovir therapy of chickenpox in immune-suppressed children - a collaborative study. J Pediatr 1982;101:622-625.
47. Morgan ER, Smalley LA. Varicella in immunocompromised children. Incidence of abdominal pain and organ involvement. Am J Dis Child 1983;137:883-885.
48. McGregor RS, Zitelli BJ, Urbach AH, Malatack JJ, Gartner IC, Jr, Varicella in pediatric orthotopic liver transplant recipients. Pediatrics 1989;83:256-261.
49. Lynfield R, Herrin JT, Rubin RH, Varicella in pediatric renal transplant recipients. Pediatrics 1992;90:216-220.
50. Feldman S, Hughes WT, Daniel CB. Varicella in children with cancer: seventy-seven cases. Pediatrics 1975;56:368-397.
51. Feldman S, Lott L. Varicella in children with cancer: impact of antiviral therapy and prophylaxis. Pediatrics 1987;80:465-472.
52. Gershon AA, Mervish N, LaRussa P, Steinberg S, Lo SH, Hodes D et al. Varicella-zoster virus infection in children with underlying human immunodeficiency virus infection. J Infect Dis 1997;176;1496-1500.
53. Arvin AM, Kushner JH, Feldman S, Baehner RL, Hammond D, Merigan TC. Human leukocyte interferon for the treatment of varicella in children with cancer. N Engl J Med 1982;306:761-765.
54. Dodd DA, Burger J, Edwards KM, Dummer JS. Varicella in a pediatric heart transplant population on nonsteroid maintenance immunosuppression. Pediatrics 2001;108:E80.
55. Derryck A, LaRussa P, Steinberg S, Capasso M, Pitt J, Gershon AA. Varicella and zoster in children with human immunodeficiency virus infection. Pediatr Infect Dis J 1998;17:931-933.
56. Balfour HH, Jr, Bean B, Laskin OL, Ambinder RE Meyers JD, Wade JC et al. Acyclovir halts progression of herpes zoster in immunocompromised patients. N Engl J Med 1983;308:1448-1453.
57. Fanelli C, Sattler FR. Acyclovir for varicella zoster infection. N Engl J Med 1984;310;987-988.
58. Whitley RJ, Gnann TW, Jr, Hinthorn D, Liu C, Pollard RB, Hayden F et al. Disseminated herpes zoster in the immunocompromised host: a comparative trial of acyclovir and vidarabine. The NIAID Collaborative Antiviral Study Group. J Infect Dis 1992;165:450-455.
59. Meszner Z, Nyerges G, Bell AR. Oral acyclovir to prevent dissemination of varicella in immunocompromised children. J Infect 1993;26:9-15.
60. Carcao MD, Lau RC, Gupta A, Huerter H, Koren G, King SM. Sequential use of intravenous and oral acyclovir in the therapy of varicella in immunocompromised children. Pediatr Infect Dis J 1998;17:626-631.
61. Kawasaki H, Takayama J, Ohira M. Herpes zoster infection after bone marrow transplantation in children. J Pediatr 1996;128:353-356.
62. Kamiyama T, Kurokawa M, Shiraki K. Characterization of the DNA polymerase gene of varicella-zoster viruses resistant to acyclovir. J Gen Virol 2001;82:2761-2765.
63. Bendel AE, Gross TG, Woods WG, Edelman CK, Balfour HH, Jr. Failure of foscarnet in disseminated herpes zoster. Lancet 1993;341:1342.
64. Visse B, Dumont B, Huraux JM, Fillet AM. Single amino acid change in DNA polymerase is associated with foscarnet resistance in a varicella-zoster virus strain recovered from a patient with AIDS. J Infect Dis 1998;178 (Suppl 1):S55-57.
65. Visse B, Huraux JM, Fillet AM. Point mutations in the varicella-zoster virus DNA polymerase gene confers resistance to foscarnet and slow growth phenotype. J Med Virol 1999;59:84-90.
66. American Academy of Pediatrics. Herpes simplex, In: 2003 Red Book: Report of the Committee on Infectious Diseases, 26th edn (Pickering LK, edn). Elk Grove Village, IL: American Academy of Pediatrics, 2003;pp344-353.
67. Prober C. Herpes Simplex Virus, 2nd edn New York: Churchill Livingstone, 2003.
68. Arvin AM, Whitley RJ. Herpes simplex infections. In: Infectious Diseases of the Fetus and Newborn Infant, 5th edn (Remington JS, Klein JO, eds). Philadelphia: WB Saunders Company, 2001;pp425-446.
69. Whitley RJ, Corey L, Arvin A, Lakeman FD, Sumaya CV, Wright PF et al. Changing presentation of herpes simplex virus infection in neonates. J Infect Dis 1988;158:109-116.
70. Whitley RJ, Nahmias AJ, Visintine AM, Fleming CL, Alford CA. The natural history of herpes simplex virus infection of mother and newborn. Pediatrics 1980;66:489-494.
71. Kimberlin DW, Lin CY, Jacobs RF, Powell DA, Frenkel LM, Gruber WC et al. Natural history of neonatal herpes simplex virus infections in the acyclovir era. Pediatrics 2001;108:223-229.
72. Whitley R, Arvin A, Prober C, Burchett S, Corey L, Powell D et al. A controlled trial comparing vidarabine with acyclovir in neonatal herpes simplex virus infection. Infectious Diseases Collaborative Antiviral Study Group. N Engl J Med 1991;324:444-449.
73. Kimberlin DW, Lin CY, Jacobs RF, Powell DA, Corey L, Gruber WC et al. Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections. Pediatrics 2001;108:230-238.
74. Kimberlin D, Powell D, Gruber W, Diaz P, Arvin A, Kumar M et al. Administration of oral acyclovir suppressive therapy after neonatal herpes simplex virus disease limited to the skin, eyes and mouth: results of a phase I/II trial. Pediatr Infect Dis J 1996;15:247-254.
75. Rimsza ME, Niggemann EH. Medical evaluation of sexually abused children: a review of 311 cases. Pediatrics 1982;69:8-14.
76. Ingram DL, Everett VD, Lyna PR, White ST, Rockwell LA. Epidemiology of adult sexually transmitted disease agents in children being evaluated for sexual abuse. Pediatr Infect Dis J 1992;11:945-950.
77. Dershewitz. Herpetic vulvovaginitis and child abuse. Am J Dis Child 1985;139:542-544.
78. Neinstein LS, Goldenring J, Carpenter S. Nonsexual transmission of sexually transmitted diseases: an infrequent occurrence. Pediatrics 1984;74:67-76.
79. Kaplan KM, Fleisher GR, Paradise JE, Friedman HN. Social relevance of genital herpes simplex in children. Am J Dis Child 1984;138:872-874.
80. Gardner M, Jones JG. Genital herpes acquired by sexual abuse of children. J Pediatr 1984;104:243-244.
81. American Academy of Pediatrics. Sexual victimization and STDs In: 2003 Red Book: Report of the Committee on Infectious Diseases, 26th edn (Pickering LK ed). Elk Grove, IL: American Academy of Pediatrics. 2003;pp162-167.
82. Douglas JM, Corey L. Fomites and herpes simplex viruses: a case for nonvenereal transmission? JAMA 1983;250:3093-3094.
83. Krugman S. Primary herpetic vulvovaginitis; Report of a case; isolation and identification of herpes simplex virus. Pediatrics 1952;9:585-588.
84. Jenny C. Sexually transmitted diseases and child abuse. Pediatr Ann 1992;21:497-503.
85. Reichman RC, Badger GJ, Mertz GJ, Corey L, Richman DD, Connor JD et al. Treatment of recurrent genital herpes simplex infections with oral acyclovir. A controlled trial. JAMA 1984;251:2103-2107.
86. Bryson YJ, Dillon M, Lovett M, Acuna G, Taylor S, Cherry JB et al. Treatment of first episodes of genital herpes simplex virus infection with oral acyclovir. A randomized double-blind controlled trial in normal subjects. N Engl J Med 1983;308:916-921.
87. Do AN, Green PA, Demmler GJ. Herpes simplex virus type 2 meningitis and associated genital lesions in a three-year-old child. Pediatr Infect Dis J 1994;13:1014-1016.
88. Nahmias AJ, Whitley RJ, Visintine AN, Takei Y, Alford CA, Jr. Herpes simplex virus encephalitis: laboratory evaluations and their diagnostic significance. J Infect Dis 1982;145:829-836.
89. Whitley RJ, Soong SJ, Linneman C, Jr, Liu C, Pazin G, Alford CA. Herpes simplex encephalitis. Clinical Assessment. JAMA 1982;247:317-320.
90. Whitley RJ, Alford CA, Hirsch MS, Schooley RT, Luby JP, Aoki FY et al. Vidarabine versus acyclovir therapy in herpes simplex encephalitis. N Engl J Med 1986;314:144-149.
91. Ito Y, Kimura H, Yabuta Y, Ando Y, Murakami T, Shiomi M et al. Exacerbation of herpes simplex encephalitis after successful treatment with acyclovir. Clin Infect Dis 2000;30:185-187.
92. Amir J, Harel L, Smetana Z, Varsano I. Treatment of herpes simplex gingivostomatitis with aciclovir in children: a randomised double-blind placebo-controlled study. BMJ 1997;314:1800-1803.
93. Spruance SL, Rea TL, Thoming C, Tucker R, Saltzman R, Boon R. Penciclovir cream for the treatment of herpes simplex labialis. A randomized, multicenter, double-blind, placebo-controlled trial. Topical Penciclovir Collaborative Study Group. JAMA 1997;277:1374-1379.
94. Spruance SL, Stewart JC, Rowe NH, McKeough MB, Wenerstrom G, Freeman DJ. Treatment of recurrent herpes simplex labialis with oral acyclovir. J Infect Dis 1990;161:185-190.
95. Spruance SL, Jones TM, Blater MM, Vargas-Cortes M, Barber J, Hill J et al. High-dose, short-duration, early valacyclovir therapy for episodic treatment of cold sores: results of two randomized, placebo-controlled, multicenter studies. Antimicrob Agents Chemother 2003;47:1072-1080.
96. Whitley RJ, Levin M, Barton N, Hershey BJ, Davis G, Keeney RE et al. Infections caused by herpes simplex virus in the immunocompromised host: natural history and topical acyclovir therapy. J Infect Dis 1984;150:323-329.
97. Shepp DH, Newton BA, Dandliker PS, Flournoy N, Meyers JD. Oral acyclovir therapy for mucocutaneous herpes simplex virus infections in immunocompromised marrow transplant recipients. Ann Intern Med 1985;102:783-785.
98. Wade JC, Newton B, Flournoy N, Meyers JD. Oral acyclovir for prevention of herpes simplex virus reactivation after marrow transplantation. Ann Intern Med 1984;100:823-828.
99. Aoki FY. Aciclovir suspension for the treatment of acute HSV gingivo-stomatitis in children: a placebo-controlled double blind trial. 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy, New Orleans, 17-20 October 1993. Abstract 399.