Enhanced ornithine decarboxylase activity is associated with attenuated rate of damage evolution and reduction of infarct volume in transient middle cerebral artery occlusion in the rat

Brain Research

Volumn 826, Issue 2, 1999, Pages 325-329

  Lukkarinen, Jouko A ^a   Gröhn, Olli H J ^a   Alhonen, Leena I ^a   Jänne, Juhani ^a   Kauppinen, Risto A ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Focal cerebral ischemia; Magnetic resonance imaging; Ornithine decarboxylase; Transgenic rat

Indexed keywords

ORNITHINE DECARBOXYLASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CELL MEMBRANE DEPOLARIZATION; ENZYME ACTIVITY; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL MEMBRANE; NEUROPROTECTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENESIS; PRIORITY JOURNAL; RAT; REPERFUSION; TRANSGENIC MOUSE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ARTERIAL OCCLUSIVE DISEASES; BRAIN CHEMISTRY; BRAIN ISCHEMIA; CAUDATE NUCLEUS; CEREBRAL CORTEX; CEREBRAL INFARCTION; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MAGNETIC RESONANCE IMAGING; ORNITHINE DECARBOXYLASE; RATS; TRANSGENES;

EID: 0345711479     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01327-X     Document Type: Article

References (28)

1. Belliveau J.W., Rosen B.R., Kantor H.L., Rzedzian R.R., Kennedy D.N., McKinstry R.C., Vevea J.M., Cohen M.S., Pykett I.L., Brady T.J. Functional cerebral imaging by susceptibility-contrast NMR. Magn. Reson. Med. 14:1990;538-546.
2. 1 of tissue water protons arise from magnetization transfer to macromolecular solid-state broadening lines. Magn. Reson. Med. 28:1992;145-152.
3. Campagne M.V., Verheul J.B., Nicolay K., Balazs R. Early evolution and recovery from excitotoxic injury in the neonatal rat brain: A study combining magnetic resonance imaging, electrical impedance, and histology. J. Cereb. Blood Flow Metab. 14:1994;1011-1023.
4. 19F NMR Magn. Reson. Med. 40:1998;1-13.
5. Finch E.D., Homer L.D. Proton nuclear magnetic resonance relaxation measurements in frog muscle. Biophys. J. 14:1974;907-921.
6. Garwood M., Ke Y. Symmetric pulses to induce arbitrary flip angles with compensation for RF inhomogeneity and resonance offsets. J. Magn. Reson. 94:1991;511-525.
7. 2. J.Cereb. Blood Flow Metab. 18:1998;911-920.
8. 1ρ imaging of acute brain ischaemia in rats, 6th ISMRM Annual Meeting, Sydney, Australia, 1998, pp. 136.
9. Halmekytö M., Hyttinen J.-M., Sinervirta R., Utriainen M., Myöhänen S., Voipio H.-M., Wahlfors J., Syrjänen S., Syrjänen K., Alhonen L., Jänne J. Transgenic mice aberrantly expressing human ornithine decarboxylase gene. J. Biol. Chem. 266:1991;19746-19751.
10. Halonen T., Sivenius J., Miettinen R., Halmekytö M., Kauppinen R., Sinervirta R., Alakuijala L., Alhonen L., MacDonald E., Jänne J., Riekkinen P.J.S. Elevated seizure threshold and impaired spatial learning in transgenic mice with putrescine overproduction in the brain. Eur. J. Neurosci. 5:1993;1233-1239.
11. Longa E.Z., Weinstein P.R., Carlson S., Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 20:1989;84-91.
12. Lukkarinen J., Gröhn O.H.J., Sinervirta R., Järvinen A., Kauppinen R.A., Jänne J., Alhonen L.I. Transgenic rats as models for studying the role of ornithine decarboxylase expression in permanent middle cerebral artery occlusion. Stroke. 28:1997;639-645.
13. Lukkarinen J., Kauppinen R.A., Koistinaho J., Halmekytö M., Alhonen L., Jänne J. Cerebral energy metabolism and immediate early gene induction following severe incomplete ischaemia in transgenic mice overexpressing the human ornithine decarboxylase gene: evidence that putrescine is not neurotoxic in vivo. Eur. J. Neurosci. 7:1995;1840-1849.
14. Lukkarinen J.A., Kauppinen R.A., Grohn O.H., Oja J.M., Sinervirta R., Jarvinen A., Alhonen L.I., Janne J. Neuroprotective role of ornithine decarboxylase activation in transient focal cerebral ischaemia: a study using ornithine decarboxylase overexpressing transgenic rats. Eur J Neurosci. 10:1998;2046-2055.
15. Metcalf B.W., Bey P., Danzin C., Jung M.J., Casara J., Vevert J.P. Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C. 4.1.1.17.) by substrate and product analogues. J. Am. Chem. Soc. 100:1978;2551-2553.
16. Miyabe M., Mori M., van Zijl P.C.M., Kirsch J.R., Eleff S.M., Koehler R.C., Traystman R.J. Correlation of the average water diffusion constant with cerebral blood flow and ischemic damage after transient middle cerebral artery occlusion in cats. J. Cereb. Blood Flow Metab. 16:1996;881-891.
17. Mori S., van Zijl P.C.M. Diffusion weighting by the trace of the diffusion tensor within a single scan. Magn. Reson. Med. 33:1995;41-52.
18. 2-weighted MRI and spectroscopy. Magn. Reson. Med. 14:1990;330-346.
19. Nichols C.G., Lopatin A.N. Inward rectifier potassium channels. Annu. Rev. Physiol. 59:1997;171-191.
20. Ogawa S., Lee T.M., Kay A.R., Tank D.W. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc. Natl. Acad. Sci. USA. 87:1990;9868-9872.
21. Paschen W. Polyamine metabolism in reversible cerebral ischemia. Cerebrovasc. Brain Metab. Rev. 4:1992;59-88.
22. Pulsinelli W.A. Pathophysiology of acute ischaemic stroke. Lancet. 339:1992;533-536.
23. Pussinen R., Sirviö J., Alhonen L., Larson J., Halmekytö M., Koivisto E., Jänne J. Preserved induction of long-term potentiation in the striatum radiatum in CA1 field of hippocampal slices from transgenic mice overexpressing ornithine decarboxylase and overproducing putrescine. Synapse. 28:1998;288-293.
24. Ransom R.W., Deschennes N.L. Polyamines regulate glycin interaction with the N-methyl-D-aspartate receptor. Synapse. 5:1990;294-298.
25. Scott R.H., Sutton K.G., Dolphin A.C. Interactions of polyamines with neuronal ion channels. Trends Neurosci. 16:1993;153-160.
26. van Bruggen N., Roberts T.P.L., Cremer J.E. The application of magnetic resonance imaging to the study of experimental cerebral ischaemia. Cerebrovasc. Brain Metab. Rev. 6:1994;180-210.
27. van Zijl P.C.M., Eleff S.M., Ulatowski J.A., Oja J.M.E., Ulug A.M., Traystman R.J., Kauppinen R.A. Quantitative assessment of blood flow, blood volume and blood oxygenation in functional magnetic resonance imaging. Nature Med. 4:1998;159-167.
28. 1ρ measurements. Arch. Biochem. Biophys. 178:1977;435-441.