Distribution and mitogen response of peripheral blood lymphocytes after exertional heat injury

Journal of Applied Physiology

Volumn 95, Issue 6, 2003, Pages 2381-2389

  DuBose, David A ^a   Bruce Wenger, C ^a   Flinn, Scott D ^b   Judy, Thomas A ^b   Dubovtsev, Alexandre I ^b   Morehouse, David H ^a  

^a U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

^b NAVAL HOSPITAL   (United States)

Author keywords

Exercise; Flow cytometry; Heat stress; Heatstroke; Hyperthermia; Leukocytes; Lymphocyte subsets; Phytohemagglutinin

Indexed keywords

CD69 ANTIGEN; MITOGENIC AGENT; PHYTOHEMAGGLUTININ;

ADULT; ARTICLE; BLOOD SAMPLING; BODY TEMPERATURE; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE SEVERITY; DYNAMIC EXERCISE; FEMALE; FLOW CYTOMETRY; FLUORESCENCE; HEAT INJURY; HEAT STRESS; HEAT STROKE; HEAT TOLERANCE; HELPER CELL; HUMAN; HUMAN EXPERIMENT; IMMUNOCOMPETENT CELL; IMMUNOPATHOLOGY; LYMPHOCYTE COUNT; MALE; NATURAL KILLER CELL; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; SOLDIER; SUMMER; SUPPRESSOR CELL; TRAINING;

EID: 0345708343     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00039.2003     Document Type: Article

References (36)

1. Bouchama A. Heat stroke: a new look at an ancient disease. Intensive Care Med 21: 623-625, 1995.
2. Bouchama A, Hussein KA, Adra C, Rezeig M, Shail EA, and Sedairy SA. Distribution of peripheral blood leukocytes in acute heat stroke. J Appl Physiol 73: 405-409, 1992.
3. Bouchama A and Knochel JP. Heat stroke. N Engl J Med 346: 1978-1988, 2002.
4. Bouchama A, Parhar RS, El-Yazigi A, Sheth K, and Al-Sedairy S. Endotoxemia and release of tumor necrosis factor and interleukin-1α in acute heat stroke. J Appl Physiol 70: 2640-2644, 1991.
5. Bouchama A, Sedairy SA, Siddiqui S, Shail S, and Rezeig M. Elevated pyrogenic cytokines in heat stroke. Chest 104: 1498-1502, 1993.
6. Costrini AM, Pitt HA, Gustafson AB, and Uddin DE. Cardiovascular manifestations of heat stroke and severe heat exhaustion. Am J Med 66: 296-302, 1979.
7. Cross MC, Radomski MW, Vanhelder WP, Rhind SG, and Shepard RJ. Endurance exercise with and without a thermal clamp: effects on leukocytes and leukocyte subsets. J Appl Physiol 81: 822-829, 1996.
8. Frisina JP, Gaudieri S, Cable T, Keast D, and Palmer TN. Effects of acute exercise on lymphocyte subsets and metabolic activity. Int J Sports Med 15: 36-41, 1994.
9. Gardner JW, Kark JA, Karnei K, Sanborn J, Gastaldo E, Burr P, and Wenger CB. Risk factors predicting exertional heat illness in male Marine Corps recruits. Med Sci Sports Exerc 28: 939-944, 1996.
10. Gottschalk PG and Thomas JE. Heat stroke. Mayo Clin Proc 41: 470-482, 1996.
11. Graber CD, Reinhold RB, Breman SG, Harley R, and Hennigar G. Fatal heat stroke. Circulating endotoxin and gram negative sepsis as complications. JAMA 216: 1195-1196, 1971.
12. Hammami MM, Bouchama A, Sedairy SA, Shail E, Ohaly YA, and Mohamed GED. Concentrations of soluble tumor necrosis factor and interleukin-6 receptors in heat stroke and heat stress. Crit Care Med 25: 1314-1319, 1997.
13. Hammami M, Bouchama A, Shail E, Enein HYA, and Sedairy SA. Lymphocyte subsets and adhesion molecules expression in heat stroke and heat stress. J Appl Physiol 84: 1615-1621, 1998.
14. Hinton JR, Rowbottom DG, Keast D, and Morton AR. Acute intensive interval training and in vitro T-lymphocyte function. Int J Sports Med 18: 130-135, 1997.
15. Hubbard RW. Effects of exercise in the heat on predisposition to heat stroke. Med Sci Sports 11: 66-71, 1979.
16. Khogali M. Epidemiology of heat illnesses during the Makkah Pilgrimages in Saudi Arabia. Int J Epidemiol 12: 267-273, 1983.
17. Levine JA. Heat stroke in the aged. Am J Med 47: 251-258, 1969.
18. Lim LCL, Fiordalisi MN, Mantelli JL, Schmitz JL, and Folds JD. A whole-blood assay for qualitative and semiquantitative measurements of CD69 surface expression on CD4 and CD8 T lymphocytes using flow cytometry. Clin Diagn Lab Immunol 5: 392-398, 1998.
19. Lind AR. Pathophysiology of heat exhaustion and heat stroke. In: Heat Stroke and Temperature Regulation, edited by Khogali M and Hales JRS. Sydney, Australia: Academic, 1983, p. 179-188.
20. Malamud N, Haymakee W, and Custer RP. Heat stroke: a clinico-pathologic study of 125 fatal cases. Mil Surgeon 99: 397-449, 1946.
21. Mazzeo RS, Rajkumar C, Rolland J, Blaher B, Jennings G, and Esler M. Immune response to a single bout of exercise in young and elderly subjects. Mech Ageing Dev 100: 121-132, 1998.
22. Mitchell JB, Dugas JP, McFarland BK, and Nelson MJ. Effect of exercise, heat stress, and hydration on immune cell number and function. Med Sci Sports Exerc 34: 1941-1950, 2002.
23. Nielsen HB and Pedersen BK. Lymphocyte proliferation in response to exercise. Eur J Appl Physiol 75: 375-379, 1997.
24. Nieman DC, Miller AR, Henson DA, Warren BJ, Gusewitch G, Johnson RL, Davis JM, Butterworth DE, Herring JL, and Nehlsen-Cannarella SL. Effect of high- versus moderate-intensity exercise on lymphocyte subpopulations and proliferation response. Int J Sports Med 15: 199-206, 1994.
25. Nieman DC, Simandle S, Henson DA, Warren BJ, Suttles J, Davis JM, Buckley KS, Ahle JC, Butterworth DE, Fagoaga OR, and Nehlsen-Cannarella SL. Lymphocyte proliferation response to 2.5 hours of running. Int J Sports Med 16: 404-409, 1995.
26. Rhind SG, Gannon GA, Shek PN, Brenner IKM, Severs Y, Zamecnik J, Buguet A, Natale VM, Shephard RJ, and Radomski MW. Contribution of exertional hyperthermia to sympathoadrenal-mediated lymphocyte subset redistribution. J Appl Physiol 87: 1178-1185, 1999.
27. Ronsen O, Pedersen OB, Oritsland TR, Bahr R, and Kjeldsen-Kragh J. Leukocyte counts and lymphocyte responsiveness associated with repeated bouts of strenuous endurance exercise. J Appl Physiol 91: 425-434, 2001.
28. Sawka MN. Body fluid responses and hypohydration during exercise-heat stress. In: Human Performance Physiology and Environmental Medicine at Terrestrial Extremes, edited by Pandolf KB, Sawka MN, and Gonzalez RR. Traverse City, MI: Benchmark, 1988, p. 227-266.
29. Shek PN, Sabiston BH, Buguet A, and Radomski MW. Strenuous exercise and immunological changes: a multiple time-point analysis of leukocyte subset, CD4/CD8 ratio, immunoglobulin production and NK cell response. Int J Sports Med 16: 466-474, 1995.
30. Shephard RJ. Exercise under hot conditions: a major threat to the immune response? J Sports Med Phys Fitness 42: 368-378, 2002.
31. Shephard RJ, Rhind S, and Shek PN. Exercise and the immune system. Natural killer cells, interleukins and related responses. Sports Med 18: 340-369, 1994.
32. Shephard RJ and Shek PN. Immune dysfunction as a factor in heat illness. Crit Rev Immunol 19: 285-302, 1999.
33. Simon HB. Hyperthermia. N Engl J Med 329: 483-487, 1993.
34. Sturm AW, Grave W, and Kwee WS. Disseminated Fusarium oxysporum infection in patient with heat stroke. Lancet 1: 968, 1989.
35. Tveda N, Kappel M, Klarlund K, Duhn S, Halkjaer-Kristensen J, Kjaer M, Galbo H, and Pedersen BK. Evidence that the effect of bicycle exercise on blood mononuclear cell proliferation responses and subsets is mediated by epinephrine. Int J Sports Med 15: 100-104, 1994.
36. Vider J, Lehtmaa J, Kullisaar T, Vihalemm T, Zilmer K, Kairane C, Landor A, Karu T, and Zilmer M. Acute immune response in respect to exercise-induced oxidative stress. Pathophysiology 7: 263-270, 2001.