Circulating nucleosomes and response to chemotherapy: An in vitro, in vivo and clinical study on cervical cancer patients

International Journal of Cancer

Volumn 104, Issue 6, 2003, Pages 663-668

  Trejo Becerril, Catalina ^a   Pérez Cárdenas, Enrique ^a   Treviño Cuevas, Homero ^a   Taja Chayeb, Lucía ^a   García López, Patricia ^a   Segura Pacheco, Blanca ^a   Chávez Blanco, Alma ^a   Lizano Soberon, Marcela ^a   González Fierro, Aurora ^a   Mariscal, Ignacio ^a   Wegman Ostrosky, Talia ^a   Dueñas González, Alfonso ^a,b  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b INSTITUTO NACIONAL DE CANCEROLOGÍA   (Mexico)

Author keywords

Cervical cancer; Circulating nucleosomes; ELISA; Neoadjuvant chemotherapy

Indexed keywords

CISPLATIN; DNA; GEMCITABINE; OXALIPLATIN; PACLITAXEL;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CELL LYSATE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOSOME; NUDE MOUSE; PRIORITY JOURNAL; TREATMENT OUTCOME; TUMOR XENOGRAFT; UTERINE CERVIX CANCER;

ADENOCARCINOMA; ADULT; AGED; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, ADENOSQUAMOUS; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; CISPLATIN; DEOXYCYTIDINE; DNA, NEOPLASM; DNA, VIRAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HELA CELLS; HUMANS; MICE; MICE, NUDE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM CIRCULATING CELLS; NUCLEOSOMES; ORGANOPLATINUM COMPOUNDS; PACLITAXEL; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; PROGNOSIS; RATS; RATS, WISTAR; TUMOR VIRUS INFECTIONS; UTERINE CERVICAL NEOPLASMS;

EID: 0345701255     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.11003     Document Type: Article

References (30)

1. Mohar A, Frias-Mendivil M. Epidemiology of cervical cancer. Cancer Invest 2000;18:584-90.
2. Lehman M, Thomas G. Is concurrent chemotherapy and radiotherapy the new standard of care for locally advanced cervical cancer? Int J Gynecol Cancer 2001;11:87-99.
3. Majno G, Joris I. Apoptosis, oncosis, and necrosis: an overview of cell death. Am J Pathol 1995;146:3-15.
4. White E. Life, death and the pursuit of apoptosis. Gene Dev 1996; 10:1-15.
5. Leist M, Nicotera P. The shape of cell death (breakthroughs and views). Biochem Biophys Res Commun 1997;236:1-9.
6. Soini Y, Raunio H, Paakko P. High-grade malignant non-Hodgkin lymphomas differ from low grade lymphomas in the extent of apoptosis and their expression of bcl-2, mcl1, Bax and p53. Tumor Biol 1998;19:176-85.
7. Gaffney ER, O'Neill AJ, Staunton MJ. In situ end-labeling, light microscopy assessment and ultrastructure of apoptosis in lung carcinoma. J Clin Pathol 1995;48:1017-21.
8. Mustonen M, Raunio H, Paakko, Soini Y. The extent of apoptosis is inversely associated with bcl-2 expression in premalignant and malignant breast lesions. Histopathology 1997;31:347-54.
9. Saegusa M, Kamata Y, Isono M, Okayasu I. Bcl-2 expression and the development of endometrial carcinoma. Mod Pathol 1996;180:275-82.
10. Trejo-Becerril C, Rivera L, Chanona J, Segura-Pacheco B, Pérez-Cardenas E, López-Graniel C, Hinojosa-García LM, Dueñas-González A. Correlation of tumor growth index with early treatment response in cervical carcinoma. J Exp Clin Cancer Res 2002;21:57-63.
11. Staammler G, Volm M. Apoptosis in non-small cell lung cancer as related to drug resistance and prognosis. Apoptosis 1996;1:95-9.
12. Basolo F, Pollina L, Fontanini G, Fiore L, Pacini F, Baldanzi A. Apoptosis and proliferation in thyroid carcinoma: correlation with bcl-2 and p53 protein expression. Br J Cancer 1997;75:537-41.
13. Koshida Y, Saegusa M, Okayasu I. Apoptosis, cell proliferation, and expression of Bcl-2 and Bax in gastric carcinomas: immunohisto-chemical and histopathological study. Br J Cancer 1997;75:367-73.
14. Chang J, Ormerod M, Powles TJ, Allred DC, Ashley SE, Dowsett M. Apoptosis and proliferation as predictors of chemotherapy response in patients with breast carcinoma. Cancer 2000;89:2145-52.
15. Anker P, Mulcahy H, Chen XQ, Stroun M. Detection of circulating tumour DNA in the blood (plasma/serum) of cancer patients. Cancer Metastasis Rev 1999;18:65-73.
16. Leon SA, Shapiro B, Sklaroff DM, Yaros DJ. Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res 1977;37:646-50.
17. Holdenrieder S, Stieber P, Forg T, Kuhl M, Schulz L, Busch M, Schalhorn A, Seidel D. Apoptosis in serum of patients with solid tumours. Anticancer Res 1999;19:2721-4.
18. Holdenrieder S, Stieber P, Bodenmuller H, Busch M, Fertig G, Furst H, Schalorn A, Schmeller N, Untch M, Seidel D. Nucleosomes in serum of patients with benign and malignant diseases. Int J Cancer (Pred Oncol) 2001;95:114-20.
19. Jen J, Wu L, Sidransky D. An overview on the isolation and analysis of circulating tumor DNA in plasma and serum. Ann N Y Acad Sci 2000;906:8-12.
20. Do TK, Kubota T, Ura HT, Yamaue H, Akiyama S, Maehara Y, Tanigawa N, Kitajima M, Takagi H. Cumulative results of chemo-sensitivity tests for antitumor agents in Japan. Japan Research Society for Appropriate Cancer Chemotherapy. Anticancer Res 2000;20: 2389-92.
21. Kuroi K, Tanaka C, Toi M. Clinical significance of plasma nucleosome levels in cancer patients. Int J Oncol 2001;19:143-8.
22. Fournie GJ, Courtin JP, Laval F, Chale JJ, Pourrat JP, Pujazon MC, Lauque D, Carles P. Plasma DNA as a marker of cancerous cell death. Investigations in patients suffering from lung cancer and in nude mice bearing human tumours. Cancer Lett 1995;91:221-7.
23. Jahr S, Hentze H, Englisch S, Hardt D, Fackelmayer FO, Hesch RD, Knippers R. DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res 2001;61:1659-65.
24. Hendry JH, West CM. Apoptosis and mitotic cell death: their relative contribution to normal-tissue and tumor radiation response. Int J Radiat Biol 1997;71:709-19.
25. Lockshin RA, Osborne B, Zakeri Z. Cell death in the third millennium. Cell Death Differ 2000;7:2-7.
26. Meyn RE, Stephens LC, Hunter NR, Milas L. Kinetics of cisplatin-induced apoptosis in murine mammary and ovarian adenocarcinomas. Int J Cancer 1995;60:725-9.
27. Gauthier VJ, Tyler LN, Mannik M. Blood clearance kinetics and liver uptake of mononucleosomes in mice. J Immunol 1996;156:1151-6.
28. Rumore P, Mualidhar B, Lin M, Lai C, Steinman CR. Hemodialysis as a model for studying endogenous plasma DNA: oligonucleosome-like structure and clearance. Clin Exp Immunol 1992;90:56-62.
29. Shapiro B, Chakrabarty M, Cohn EM, Leon SA. Determination of circulating DNA levels in patients with benign or malignant gastro-intestinal disease. Cancer 1987;51:2116-20.
30. 99m)Tc recombinant human Annexin V in human tumors after one course of chemotherapy as a predictor of tumor response and patient prognosis. Clin Cancer Res 2002;8:2766-74