The use of IL-6 induction as a human biomarker for inflammatory agents in water

Water Science and Technology

Volumn 47, Issue 3, 2003, Pages 71-75

  Pool, E J ^a   Jagals, C ^b   Van Wyk, J H ^a   Jagals, P ^b  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b CENTRAL UNIVERSITY OF TECHNOLOGY   (South Africa)

Author keywords

IL 6; Inflammatory activity; Water quality; Whole blood culture

Indexed keywords

BIOASSAY; BLOOD; CHLORINATION; RIVERS; WATER TREATMENT;

WHITE BLOOD CULTURE (WBC) ASSAY SYSTEM;

WATER ANALYSIS;

ANTIINFLAMMATORY AGENT; BIOLOGICAL MARKER; INTERLEUKIN 6; RIVER WATER;

SAMPLING; URBAN AREA; WATER QUALITY; WATER TREATMENT;

BIOMARKER; SAMPLING; URBAN AREA; WATER QUALITY; WATER TREATMENT;

BLOOD CULTURE; CHLORINATION; CONFERENCE PAPER; ENVIRONMENTAL MONITORING; HEALTH HAZARD; HUMAN; IMMUNE SYSTEM; RESIDENTIAL CARE; RISK FACTOR; RIVER; SOUTH AFRICA; WASTE WATER TREATMENT PLANT; WATER CONTAMINATION; WATER MANAGEMENT; WATER QUALITY; WATER SAMPLING;

FREE STATE; MANGUANG; SOUTH AFRICA;

EID: 0345701245     PISSN: 02731223     EISSN: None     Source Type: Journal    
DOI: 10.2166/wst.2003.0164     Document Type: Conference Paper

References (19)

1. Atlas, R.M. and Bartha, R. (1993). Microbial Ecology: Fundamentals and Applications. 3rd Edition, chapter 7. The Benjamin/Cummings Publishing Company, Inc.
2. Baumann, H. and Gauldie, J. (1994). The acute phase response. Immunol. Today, 15, 74-80.
3. Couper, I. and Walker, A.R. (1997). Causes of death in a rural hospital in South Africa. Afr. J. Med., 43(8), 219-22.
4. DCD (1997). Municipal Infrastructure Framework. Dept of Constitutional Development, RSA.
5. Duff, G.W. and Atkins, E. (1982). The detection of endotoxins by in vitro production of endogenous pyrogen: Comparison with Limulus Amoebocyte Lysate gelation. J. Immunol. Methods, 52, 323-31.
6. Fennrich, S., Fisher, M., Hartung, T., Lexa, P., Montag-Lessing, T., Sonntag, H.G., Weigandt, M. and Wendel, A. (1999). Detection of endotoxins and other pyrogens using human whole blood. Dev. Biol. Stand., 101, 131-9.
7. Finch-Arietta, M.B. and Cochran, F.R. (1991). Cytokine production in whole blood ex vivo. Agents Actions, 34, 49-52.
8. Gauldie, J., Richards, C., Harnish, D., Lansdorp, P. and Baumann, H. (1987). Interferon beta2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proc. Natl. Acad. Sci. USA, 849(20), 7251-5.
9. Hu, W.J., Zhang, G.S., Chu, F.S., Meng, H.D. and Meng, Z.H. (1984). Purification and partial characterisation of flavotoxin A. Appl. Environ. Microbiol., 48(4), 690-3.
10. Meyer, O. (1995). Superantigens and their implication in autoimmune diseases. Presse. Med., 24(25), 1171-7.
11. Mimms, C.A. (1990). The Pathogenesis of Infectious Disease. Academic Press, London, San Diego.
12. Pool, E.J., Van Wyk, J.H. and Leslie, A.J. (2000). Inflammatory activity as an indicator of water quality: The use of human whole blood cultures. J. Immunoassay, 21, 387-399.
13. Pool, E.J. and Bouic, P.J. (1999a). Differentiation between endotoxin and non-endotoxin pyrogens in human albumin solutions using an ex vivo whole blood culture assay. J. Immunoassay, 20(1-2), 79-89.
14. Pool, E.J. and Bouic, P.J. (1999b). The detection of pyrogens in sera from patients with symptoms of sepsis using an ex vivo whole blood culture assay. J. Immunoassay, 20(1-2), 1-11.
15. Pool, E.J., Johaar, G., James, S., Petersen, I. and Bouic, P.J. (1998). The detection of pyrogens in blood products using an ex vivo whole blood culture assay. J. Immunoassay, 19(2-3), 95-111.
16. Poole, S., Thorpe, R., Meager, A. and Gearing, A.J.H. (1988b). Assay of pyrogenic contamination in pharmaceuticals by cytokine release from monocytes. Dev. Biol. Stan., 69, 121-23.
17. Poole, S., Thorpe, R., Meager, A., Hubbard, A. and Gearing, A.J.H. (1988a). Detection of pyrogens by cytokine release. Lancet, January 16, 130.
18. Rafferty, B., Mower, J.A., Tantak, Y.S. and Poole, S. (1991). Measurement of cytokine production by the monocytic cell line Mono Mac 6 using novel immunoradiometric assays for IL-1β and IL-6. J. Immunol. Methods, 144, 69-76.
19. Van Schirning, Y.E., Kfur, R., Cabelli, V., Franklin, L. and Joubert, G. (1972). Morbidity among bathers exposed to polluted seawater: A prospective study. S. Afr. Med. J., 81(11), 543-6.