Role of HIF-1 in Physiological Adaptation of the Carotid Body during Chronic Hypoxia

Advances in Experimental Medicine and Biology

Volumn 536, Issue , 2002, Pages 593-601

  Fung, Man Lung ^a   Tipoe, George L ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN 1; HYPOXIA INDUCIBLE FACTOR 1; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; CALCIUM CELL LEVEL; CARDIOVASCULAR RESPONSE; CAROTID BODY; CAROTID BODY CHEMORECEPTOR; CHEMORECEPTOR; CONFERENCE PAPER; CONTROLLED STUDY; DNA BINDING; GENE EXPRESSION; HYPOXIA; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANOXIA; CAROTID BODY; CHRONIC DISEASE; ENDOTHELIN-1; GENE EXPRESSION REGULATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; MODELS, NEUROLOGICAL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

ANIMALIA;

EID: 0345550461     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (22)

1. Bee, D., Pallott, D. J., and Barer, G. R., 1986, Division of type 1 and endothelial cells in the hypoxic rat carotid body. Acta. Anat. 126: 226-229.
2. Bisgard, G. E., 2000, Carotid body mechanisms in acclimatization to hypoxia. Resp. Physiol., 121: 237-246.
3. Chavez, J. C., Agani, F., Piciule, P., and LaManna, J. C., 2000, Expression of hypoxiainducible factor-1α in the brain of rats during chronic hypoxia. J. Appl. Physiol. 89: 1937-1942.
4. Chen, J., He, J., Dinger, B., and Fidone, J., 2000, Cellular mechanisms involved in rabbit carotid bidy excitation elicited by endothelin peptides. Respir. Physiol. 121: 13-23.
5. A receptor expression. Pflügers Archiv 443: 565-573.
6. Clarke, J. A., Daly, M. B., Marshall, J. M., Ead, H. W., and Hennessy, E. M., 2000, Quantitative studies of the vasculature of the carotid body in the chronically hypoxic rat. Braz. J. Med. Biol. Res. 33: 331-340.
7. Dhillon, D. P., Barer, G. R., and Walsh, M., 1984, The enlarged carotid body of the chronically hypoxic and hypercapnic rat: a morphometric analysis. Q. J. Exp. Physiol. 69: 301-317.
8. Fung, M.-L., Lam, S.-Y., Chen, Y., Dong, X., and Leung, P. S., 2001a, Functional expression of angiotensin II receptors in type-1 cells of the rat carotid body. Pflügers Archiv 441: 474-480.
9. Fung, M.-L., Ye, J.-S., and Fung, P. C. W., 2001b, Acute hypoxia elevates nitric oxide generation in rat carotid body in vitro. Pflügers Archiv 442: 903-909.
10. Gonzalez, C., Almaraz, L., Obeso, A., and Rigual, R., 1994, Carotid body chemoreceptors: From natural stimuli to sensory discharges. Physiol. Rev. 74: 829-898
11. Gozal, D., Gozal, E., Gozal, Y. M., and Torres, J. E., 1996, Nitric oxide synthase isoforms and peripheral chemoreceptor stimulation in conscious rats. Neuroreport 7: 1145-1148.
12. Harik, S. I., Hritz, M. A., and LaManna, J. C., 1995, Hypoxia-induced brain angiogenesis in the adult rat. J. Physiol. (Lond.) 485: 525-530.
13. He, L., Chen, J., Dinger, B., Stensaas, L., and Fidone, S., 1996, Endothelin modulates chemoreceptor cell function in mammalian carotid body. Adv. Exp. Med. Biol. 410: 305-310.
14. 2 tension. Am. J. Physiol. 271: C1172-1180.
15. Kline, D. D., Yang, T., Premkumar, R. D., Thomas, A. J., and Prabhakar, N. R., 2000, Blunted respiratory responses to hypoxia in mutant mice deficient in nitric oxide synthase-3. J. Appl. Physiol. 88: 1496-1508.
16. Lahiri, S., Rozanov, C., Roy, A., Storey, B., and Buerk, D. G., 2001, Regulation of oxygen sensing in peripheral arterial chemoreceptors. Int. J. Biochem. & Cell Biol. 33: 755-774.
17. McGregor, K. H., Gil, J., and Lahiri, S., 1984, A morphometric study of the carotid body in chronically hypoxic rats. J. Appl. Physiol. 57: 1430-1438.
18. Paciga, M., Vollmer, C., and Nurse, C., 1999, Role of ET-1 in hypoxia-induced mitosis of cultured rat carotid body chemoreceptors. Neuroreport 10: 3739-3744.
19. Palmer, L. A., Semenza, G. L., Stoler, M. H., and Johns, R. A., 1998, Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. Am. J. Physiol. 274: L212-219.
20. Prabhakar, N. R., 1999, NO and CO as second messengers in oxygen sensing in the carotid body. Resp. Physiol. 115: 161-168.
21. Semenza, G. L., 2000, HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J. Appl. Physiol. 88: 1474-1480.
22. Wang, Z.-Z., Dinger, B. G., Stensaas, L. J., and Fidone, S. J., 1995, The role of nitric oxide in carotid chemoreception. Biol. Signals 4: 109-116.