Intoxication due to negative canrenone interference in digoxin drug monitoring

Lancet

Volumn 354, Issue 9185, 1999, Pages 1176-1177

  Steimer, Werner ^a   Müller, Christine ^a   Eber, Barbara ^a   Emmanuilidis, Klaus ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CANRENOATE POTASSIUM; CANRENONE; DIGITALIS LIKE FACTOR; DIGOXIN; SPIRONOLACTONE;

AGED; ARTICLE; ASCITES; AUTOPSY; BIOASSAY; CARDIOPULMONARY INSUFFICIENCY; CASE REPORT; CAUSE OF DEATH; CONTROLLED STUDY; DIGOXIN BLOOD LEVEL; DRUG COMPETITION; DRUG DETERMINATION; DRUG INTOXICATION; DRUG MONITORING; HEART ATRIUM FIBRILLATION; HEART VENTRICLE EXTRASYSTOLE; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; MALE; MULTIPLE ORGAN FAILURE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SEPTICEMIA; TACHYCARDIA; TARGET ORGAN; ULTRAFILTRATION;

EID: 0345425642     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(99)03818-0     Document Type: Article

References (5)

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2. Pleasants R.A., Williams D.M., Porter R.S., Gadsden R.H. Reassessment of cross-reactivity of spironolactone metabolites with four digoxin immunoassays. Ther Drug Monit. 11:1989;200-204.
3. Huffman D.H. The effect of spironolactone and canrenone on the digoxin radioimmunoassay. Res Commun Chem Pathol Pharmacol. 9:1974;787-790.
4. Datta P., Dasgupta A. Bidirectional (positive/negative) interferencein a digoxin immunoassay: importance of antibody specificity. Ther Drug Monit. 20:1998;352-357.
5. Jortani S.A., Miller J.J., Helm R.A., Johnson N.A., Valdes R. Suppression of immunoassay results by cross-reactivity. J Clin Ligand Assay. 20:1997;177-179.