Biodistribution of protoporphyrin IX in rat urinary bladder after intravesical instillation of 5-aminolevulinic acid

Journal of Urology

Volumn 155, Issue 5, 1996, Pages 1744-1748

  Chang, Shi Chung ^a   Macrobert, Alexander J ^b   Bown, S G ^b  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b NONE

Author keywords

aminolevulinic acid; photosensitizing agents; phototherapy; protoporphyrins

Indexed keywords

AMINOLEVULINIC ACID; PROTOPORPHYRIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG STABILITY; FEMALE; FLUORESCENCE MICROSCOPY; INTRAVESICAL DRUG ADMINISTRATION; NONHUMAN; PH; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION;

EID: 0029979540     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(01)66190-1     Document Type: Article

References (19)

1. Lipson, R. L., Baldes, E. J. and Olsen, A. M.: Hematoporphyrin derivative: a new aid for endoscopic detection of malignant disease. J. Thorac. Cardiovasc. Surg., 42: 623, 1961.
2. Dougherty, T. J., Gomer, C. J. and Weishaupt, K. R.: Energetics and efficiency of photoinactivation of murine tumor cells containing hematoporphyrin. Cancer Res., 36: 2330, 1976.
3. Pass, H. I.: Photodynamic therapy in oncology: mechanisms and clinical use. J. Natl. Cancer Inst., 85: 443, 1993.
4. Kennedy, J. C., Pottier, R. H. and Pross, D. C.: Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. J. Photochem. Photobiol. B., 6: 143, 1990.
5. Regula, J., MacRobert, A. J., Gorchein, A., Buonaccorsi, G. A., Thorpe, S. M., Spencer, G. M., Hatfield, A. R. W. and Bown, S. G.: Photosensitisation and photodynamic therapy of oesophageal, duodenal and colorectal tumours using 5-aminolaevulinic acid induced protoporphyrin IX: a pilot study. Gut, 36: 67, 1995.
6. Bedwell, J., MacRobert, A. J., Phillips, D. and Bown, S. G.: Fluorescence distribution and photodynamic effect of ALA-induced PpIX in the DMH rat colonic tumour model. Br. J. Cancer, 65: 818, 1992.
7. Kriegmair, M., Baumgartner, R., Susanne, S., Riesenberg, R., Hofstetter, A., Knuchel, R. and Steinbach, P.: Photodynamic treatment of urothelial cancer following intravesical application of 5-aminolaevulinic acid in a rat bladder tumor model. J. Urol., abstract 1163, 151: 518A, 1994.
8. Divans, X. G., Kennedy, J. C. and Pottier, R. H.: Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5-aminolaevulinic acid correlates with localized protoporphyrin IX fluorescence. Am. J. Pathol., 136: 891, 1990.
9. Loh, C. S., Bedwell, A. J., MacRobert, A. J., Krasner, N., Phillips, D. and Bown, S. G.: Photodynamic therapy of the normal rat stomach: a comparative study between di-sulphonated aluminium phthalocyanine and 5-aminolaevulinic acid. Br. J. Cancer, 66: 452, 1992.
10. Loh, C. S., MacRobert, A. J., Bedwell, J., Regula, J., Krasner, N. and Bown, S. G.: Oral versus intravenous administration of 5-aminolaevulinic acid for photodynamic therapy. Br. J. Cancer, 68: 41, 1993.
11. Loh, C. S., Vernon, D., MacRobert, A. J., Bedwell, J., Bown, S. G. and Brown, S. B.: Endogenous porphyrin distribution induced by 5-aminolaevulinic acid in the tissue layers of the gastrointestinal tract. J. Photochem. Photobiol. B., 20: 47, 1993.
12. Pottier, R. H., Chow, Y. F. A., LaPlante, J.-P., Truscott, T. G., Kennedy, J. C. and Beiner, L. A.: Non-invasive technique for obtaining fluorescence excitation and emission spectra in vivo. Photochem. Photobiol., 44: 679, 1986.
13. Harty, J. I., Amin, M., Wieman, T. J., Tseng, M. T., Ackerman, D. and Broghamer, W.: Complications of whole bladder dihematoporphyrin ether photodynamic therapy. J. Urol., 141: 1341, 1989.
14. Pope, A. J. and Bown, S. G.: The morphological and functional changes in rat bladder following photodynamic therapy with phthalocyanine photosensitization. J. Urol., 145: 1064, 1991.
15. Bridges, J. W., Sargent, N. S. E. and Upshall, D. G.: Rapid absorption from the urinary bladder of a series of n-alkyl carbamate: a route for the recirculation of drug. Br. J. Pharmacol., 66: 283, 1979.
16. 14C-labelled tryptophan, its metabolites, glycine and glucose by the urinary bladder of the mouse. Invest. Urol., 3: 577, 1966.
17. Rodriguez, M. N., Huttmann, G. and Diddens, H.: Chemical instability of 5-aminolevulinic acid (ALA) in aqueous solution. S.P.I.E., 2371: 204, 1995.
18. Leveckis, J., Burn, J. L., Brown, N. J. and Reed, M. W. R.: Kinetics of endogenous protoporphyrin IX induction by aminolevulinic acid: preliminary studies in the bladder. J. Urol., 152: 550, 1994.
19. Bachor, R., Flotte, T. J., Scholz, M., Dretler, S. and Hasan, T.: Comparison of intravenous and intravesical administration of chloro-aluminum sulfonated phthalocyanine for photodynamic treatment in rat bladder cancer model. J. Urol., 147:1404, 1992.