In vitro interaction of AFB1 with rabbit liver monooxygenase activities

Chemico-Biological Interactions

Volumn 107, Issue 3, 1997, Pages 145-155

  Guerre, Philippe ^a   Calléja, Cécile ^b   Burgat, Viviane ^a   Galtier, Pierre ^b  

^a UNIVERSITÉ DE TOULOUSE   (France)

^b CEMAGREF   (France)

Author keywords

Aflatoxin B1; Cytochrome P450; Rabbit liver microsomes

Indexed keywords

AFLATOXIN B1; CYTOCHROME P450; UNSPECIFIC MONOOXYGENASE;

ANIMAL TISSUE; ARTICLE; COMPETITIVE INHIBITION; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; IN VITRO STUDY; LIVER METABOLISM; LIVER MICROSOME; MOLECULAR INTERACTION; NONHUMAN; RABBIT; XENOBIOTIC METABOLISM;

AFLATOXIN B1; ANILINE HYDROXYLASE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BINDING, COMPETITIVE; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; KINETICS; MALE; MICROSOMES, LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; RABBITS;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0345404282     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(97)00086-0     Document Type: Article

References (24)

1. B.D. Roebuck, Y.Y. Maxuitenko, Biochemical mechanisms and biological implications of the toxicity of aflatoxins as related to aflatoxin carcinogenesis, in: D.L. Eaton, J.D. Groopman (Eds.), The Toxicology of Aflatoxins: Human Health, Veterinary and Agricultural Significance, Academic Press, London, 1994, pp. 27-45.
2. D.L. Eaton, H.S. Ramsdell, G.E. Neal, Biotransformation of aflatoxins, in: D.L Eaton, J.D. Groopman (Eds.), The Toxicology of Aflatoxins: Human Health, Veterinary and Agricultural Significance, Academic Press, London, 1994, pp. 45-72.
3. Mgbodile M.U.K., Holscher M., Neal R.A. A possible protective role for reduced glutathione in Aflatoxine B1 toxicity: effect of pretreatment of rats with phenobarbital and 3-methylcholanthrene on aflatoxin toxicity. Toxicol. Appl. Pharmacol. 34:1975;128-142.
4. Kamdem L., Siest G., Magdalou J. Differential toxicity of aflatoxin B1 in male and female rats: relationship with hepatic drug-metabolizing enzymes. Biochem. Pharmacol. 31:1982;3057-3062.
5. Galtier P., Larrieu G., Le Bars J. Comparative incidence of oral ochratoxicosis and aflatoxicosis on the activity of drug metabolizing enzymes in rat liver. Toxicol. Lett. 23:1984;341-347.
6. Gawai K.R., Vodela J.K., Dalvi P.S., Dalvi R.R. Comparative assessment of the effect of aflatoxin B1 on hepatic dysfunction in some mammalian and avian species. Comp. Biochem. Physiol. 101C:1992;415-418.
7. Mbiapo F., Moudipa Ph.D., Moudipa P.F. Hepatic microsomal drug-metabolizing enzyme in aflatoxin B1-treated rats after feeding vegetable diet Amaranthus hybridus. Nutr. Res. 13:1993;941-951.
8. Raisuddin S., Parmar D., Zaidi S.I.A.et al. Aflatoxin induces depletion of activities of phase I biotransformation enzymes in growing rats. Eur. J. Drug Metab. Pharmacokinet. 2:1994;163-168.
9. Guerre P., Eeckhoutte C., Larrieu G., Burgat V., Galtier P. Dose-related effect of aflatoxin B1 on liver drug metabolizing enzymes in rabbit. Toxicology. 108:1996;39-48.
10. Ball R.W., Coulombe R.A. Comparative biotransformation of aflatoxin B1 in mammalian airway epithelium. Carcinogenesis. 12:1991;305-310.
11. Daniels J.M., Massey T.E. Modulation of aflatoxin B1 biotransformation in rabbit pulmonary and hepatic microsomes. Toxicology. 74:1992;19-32.
12. Putt D.A., Ding X., Coon M.J., Hollenberg P.F. Metabolism of aflatoxin B1 by rabbit and rat nasal mucosa microsomes and purified cytochrome P450, including isoforms 2A10 and 2A11. Carcinogenesis. 16:1995;1411-1417.
13. Galtier P., Battaglia A., More J., Franc M. Impairement of drug metabolism by the liver in experimental fascioliasis in the rat. J. Pharm. Pharmacol. 35:1983;729-733.
14. Lowry O.H., Rosenbrough N.J., Farral A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
15. Omura T., Sato R. A new cytochrome in liver microsomes. J. Biol. Chem. 237:1962;1375-1376.
16. B.N. La Du, H.G. Mandel, E.L. Way, Determination of microsomal aniline hydroxylase, in: B.N. La Du, H.G. Mandel, E.L. Way (Eds), Fundamentals of Drug Metabolism and Drug Disposition, Waverly Press, Baltimore, 1972, pp. 569-572.
17. B.G. Lake, Preparation and characterisation of microsomal fractions for studies on xenobiotic metabolism, in: K. Snell, B. Mullock (Eds.), Biochemical Toxicology, IRL Press, Oxford, 1987, pp. 183-215.
18. Cochin J., Axelrod J. Biochemical and pharmacological changes in the rat following chronic administration of morphine, nalorphine and normorphine. J. Pharmacol. Exp. Ther. 125:1959;105-115.
19. P. Guerre, T. Pineau, P. Costet, G. Larrieu, V. Burgat, P. Galtier, Compared mechanisms of cytochrome P450 decreases observed in rabbit liver and primary cultures of rabbit hepatocytes exposed to AFB1, Toxicol. Appl. Pharmacol. (submitted).
20. McHugh T.E., Atkins W.M., Racha J.K., Kunze K.L., Eaton D.L. Binding of the aflatoxin-glutathione conjugate to mouse glutathione S-transferase A3-3 is saturated at only one ligand per dimer. J. Biol. Chem. 271:1996;27470-27474.
21. Koop D.R., Crump B.L., Nordplom G.D., Coon M.J. Immunochemical evidence for induction of alcohol-oxidizing cytochrome P450 of rabbit liver microsomes by diverse agents: ethanol, imidazole, trichloroethylene, acetone, pyrazole, and isoniazid. Proc. Natl. Acad. Sci. USA. 82:1985;4065-4069.
22. Van de Wiel J.A.G., Fijneman P.H.S., Teeuw K.B., Van Ommen B., Noordhoek J., Bos R.P. Influence of long-term ethanol treatment on rat liver biotransformation enzymes. Alcohol. 10:1993;397-402.
23. Gallagher E.P., Kunze K.L., Stapleton P.L., Eaton D.L. The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4. Toxicol. Appl. Pharmacol. 141:1996;595-606.
24. Pineau T., Daujat M., Pichard L.et al. Developmental expression of rabbit cytochrome P450 CYP1A 1, CYP1A2, and CYP3A6 genes. Effect of weaning and rifampicin. Eur. J. Biochem. 197:1991;145-153.