Inhibition of steroidogenesis in Leydig cells by Müllerian-inhibiting substance

Molecular and Cellular Endocrinology

Volumn 211, Issue 1-2, 2003, Pages 99-104

  Fynn Thompson, Eric ^a   Cheng, Henry ^a   Teixeira, Jose ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Anti M llerian hormone; Leydig cells; M llerian inhibiting substance; Steroidogenesis

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOCHROME P450; MUELLERIAN INHIBITING FACTOR;

BINDING SITE; CONFERENCE PAPER; ENZYME INDUCTION; GENE OVEREXPRESSION; LEYDIG CELL; MEMBRANE TRANSPORT; MUELLERIAN DUCT; NONHUMAN; OVARY FOLLICLE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PUBERTY; SIGNAL TRANSDUCTION; STEROIDOGENESIS;

EID: 0345377818     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2003.09.015     Document Type: Conference Paper

References (29)

1. Bardin, C.W., Hardy, M.C., Catterall, J.F., 1995. Androgens, in: Adashi, E.Y., et al. (Eds.), Reproductive Endocrinology, Surgery, and Technology. Lippincott-Raven, Philadelphia, PA, pp. 505-525.
2. Behringer R.R., Cate R.L., Froelick G.J., Palmiter R.D., Brinster R.L. Abnormal sexual development in transgenic mice chronically expressing Müllerian-inhibiting substance. Nature. 345:1990;167-170.
3. Behringer R.R., Finegold M.J., Cate R.L. Mullerian-inhibiting substance function during mammalian sexual development. Cell. 79:1994;415-425.
4. Belville C., Josso N., Picard J.Y. Persistence of Mullerian derivatives in males. Am. J. Med. Genet. 89:1999;218-223.
5. De Santa Barbara P., Moniot B., Poulat F., Boizet B., Berta P. Steroidogenic factor-1 regulates transcription of the human anti-Mullerian hormone receptor. J. Biol. Chem. 273:1998;29654-29660.
6. Dufau M.L. The luteinizing hormone receptor. Annu. Rev. Physiol. 60:1998;461-496.
7. Durlinger A.L., Gruijters M.J., Kramer P., Karels B., Ingraham H.A., Nachtigal M.W., Uilenbroek J.T., Grootegoed J.A., Themmen A.P. Anti-Mullerian hormone inhibits initiation of primordial follicle growth in the mouse ovary. Endocrinology. 143:2002;1076-1084.
8. Durlinger A.L., Kramer P., Karels B., de Jong F.H., Uilenbroek J.T., Grootegoed J.A., Themmen A.P. Control of primordial follicle recruitment by anti-Müllerian hormone in the mouse ovary. Endocrinology. 140:1999;5789-5796.
9. Josso N., Cate R.L., Picard J.Y., Vigier B., di Clemente N., Wilson C., Imbeaud S., Pepinsky R.B., Guerrier D., Boussin L., Legeai L., Carré-Eusebe D. Anti-Müllerian hormone: the Jost factor. Recent Prog. Horm. Res. 48:1993;1-59.
10. Kananen K., Markkula M., Mikola M., Rainio E.M., McNeilly A., Huhtaniemi I. Gonadectomy permits adrenocortical tumorigenesis in mice transgenic for the mouse inhibin alpha-subunit promoter/simian virus 40 T-antigen fusion gene: evidence for negative autoregulation of the inhibin alpha-subunit gene. Mol. Endocrinol. 10:1996;1667-1677.
11. Laurich V.M., Trbovich A.M., O'Neill F.H., Houk C.P., Sluss P.M., Payne A.H., Donahoe P.K., Teixeira J. Mullerian Inhibiting Substance blocks the protein kinase A-induced expression of cytochrome P450 17{alpha}-hydroxylase/ C17-20 lyase mRNA in a mouse Leydig cell line independent of cAMP responsive element binding protein phosphorylation. Endocrinology. 143:2002;3351-3360.
12. Lee M.M., Donahoe P.K., Hasegawa T., Silverman B., Crist G.B., Best S., Hasegawa Y., Noto R.A., Schoenfeld D., MacLaughlin D.T. Müllerian inhibiting substance in humans: normal levels from infancy to adulthood. J. Clin. Endocrinol. Metab. 81:1996;571-576.
13. Lee M.M., Seah C.C., Masiakos P.T., Sottas C.M., Preffer F.I., Donahoe P.K., Maclaughlin D.T., Hardy M.P. Müllerian-inhibiting substance type II receptor expression and function in purified rat Leydig cells. Endocrinology. 140:1999;2819-2827.
14. Lejeune H., Habert R., Saez J.M. Origin, proliferation and differentiation of Leydig cells. J. Mol. Endocrinol. 20:1998;1-25.
15. Lyet L., Louis F., Forest M.G., Josso N., Behringer R.R., Vigier B. Ontogeny of reproductive abnormalities induced by deregulation of anti-müllerian hormone expression in transgenic mice. Biol. Reprod. 52:1995;444-454.
16. Masiakos P.T., MacLaughlin D.T., Maheswaran S., Teixeira J., Fuller A.F. Jr., Shah P.C., Kehas D.J., Kenneally M.K., Dombkowski D.M., Ha T.U., Preffer F.I., Donahoe P.K. Human ovarian cancer, cell lines, and primary ascites cells express the human Mullerian inhibiting substance (MIS) type II receptor, bind, and are responsive to MIS. Clin. Cancer Res. 5:1999;3488-3499.
17. McGee E.A., Smith R., Spears N., Nachtigal M.W., Ingraham H., Hsueh A.J. Müllerian inhibitory substance induces growth of rat preantral ovarian follicles. Biol. Reprod. 64:2001;293-298.
18. Mishina Y., Rey R., Finegold M.J., Matzuk M.M., Josso N., Cate R.L., Behringer R.R. Genetic analysis of the Müllerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation. Genes Dev. 10:1996;2577-2587.
19. Parker K.L., Schedl A., Schimmer B.P. Gene interactions in gonadal development. Annu. Rev. Physiol. 61:1999;417-433.
20. Racine C., Rey R., Forest M.G., Louis F., Ferré A., Huhtaniemi I., Josso N., di Clemente N. Receptors for anti-Müllerian hormone on Leydig cells are responsible for its effects on steroidogenesis and cell differentiation. Proc. Natl. Acad. Sci. U.S.A. 95:1998;594-599.
21. Rey R., Lordereau-Richard I., Carel J.C., Barbet P., Cate R.L., Roger M., Chaussain J.L., Josso N. Anti-Müllerian hormone and testosterone serum levels are inversely related during normal and precocious pubertal development. J. Clin. Endocrinol. Metab. 77:1993;1220-1226.
22. Rouiller-Fabre V., Carmona S., Merhi R.A., Cate R., Habert R., Vigier B. Effect of anti-Müllerian hormone on Sertoli and Leydig cell functions in fetal and immature rats. Endocrinology. 139:1998;1213-1220.
23. Segev D.L., Hoshiya Y., Hoshiya M., Tran T.T., Carey J.L., Stephen A.E., MacLaughlin D.T., Donahoe P.K., Maheswaran S. Mullerian-inhibiting substance regulates NF-kappa B signaling in the prostate in vitro and in vivo. Proc. Natl. Acad. Sci. U.S.A. 99:2002;239-244.
24. Segev D.L., Hoshiya Y., Stephen A.E., Hoshiya M., Tran T.T., MacLaughlin D.T., Donahoe P.K., Maheswaran S. Mullerian inhibiting substance regulates NFkappaB signaling and growth of mammary epithelial cells in vivo. J. Biol. Chem. 276:2001;26799-26806.
25. Teixeira J., Fynn-Thompson E., Payne A.H., Donahoe P.K. Müllerian-inhibiting substance regulates androgen synthesis at the transcriptional level. Endocrinology. 140:1999a;4732-4738.
26. Teixeira J., Kehas D.J., Antun R., Donahoe P.K. Transcriptional regulation of the rat Müllerian inhibiting substance type II receptor in rodent Leydig cells. Proc. Natl. Acad. Sci. U.S.A. 96:1999;13831-13838.
27. Teixeira J., Maheswaran S., Donahoe P.K. Mullerian inhibiting substance: an instructive developmental hormone with diagnostic and possible therapeutic applications. Endocrinol. Rev. 22:2001;657-674.
28. Trbovich A.M., Sluss P.M., Laurich V.M., O'Neill F.H., MacLaughlin D.T., Donahoe P.K., Teixeira J. Müllerian Inhibiting Substance lowers testosterone in luteinizing hormone-stimulated rodents. Proc. Natl. Acad. Sci. U.S.A. 98:2001;3393-3397.
29. Zhang P., Hammer F., Bair S., Wang J., Reeves W.H., Mellon S.H. Ku autoimmune antigen is involved in placental regulation of rat P450c17 gene transcription. DNA Cell Biol. 18:1999;197-208.