The mouse homeodomain protein OTX2 regulates NCAM promoter activity

Molecular Brain Research

Volumn 67, Issue 2, 1999, Pages 292-295

  Nguyen Ba Charvet, Kim Tuyen ^a   Von Boxberg, Ysander ^a   Godement, Pierre ^a  

^a CNRS   (France)

Author keywords

Homeobox; Mouse; NCAM; Otx2; Promoter activity

Indexed keywords

HOMEODOMAIN PROTEIN; NERVE CELL ADHESION MOLECULE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSFECTION; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; BRAIN CHEMISTRY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; MICE; NERVE TISSUE PROTEINS; NEURAL CELL ADHESION MOLECULES; OTX TRANSCRIPTION FACTORS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; TRANS-ACTIVATORS; TRANSFECTION;

ANIMALIA; MAMMALIA;

EID: 0345355154     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(99)00071-6     Document Type: Article

References (21)

1. Acampora D., Acantaggiato V., Tuorto F., Simeone A. Genetic control of brain morphogenesis through Otx gene dosage requirement. Development. 124:1997;3639-3650.
2. Acampora D., Mazan S., Lallemand Y., Avantaggiato V., Maury M., Simeone A., Brûlet P. Forebrain and midbrain regions are deleted in Otx2(-/-) mutants due to a defective anterior neuroectoderm specification during gastrulation. Development. 121:1995;3279-3290.
3. Barbas J.A., Chaix J.-C., Steinmetz M., Goridis C. Differential splicing and alternative polyadenylation generates distinct NCAM transcripts and proteins in the mouse. EMBO J. 7:1988;625-632.
4. Boncinelli E. Early CNS development: distal-less related genes and forebrain development. Curr. Opin. Neurobiol. 4:1994;29-36.
5. Edelman G.M., Jones F.S. Outside and downstream of the homeobox. J. Biol. Chem. 268:1993;20683-20686.
6. Gherzi R., Briata P., Boncinelli E., Ponassi M., Querze G., Viti F., Corte G., Zardi L. The human homeodomain protein OTX2 binds to the human tenascin-C promoter and trans-represses its activity in transfected cells. DNA Cell Biol. 16:1997;559-567.
7. Goodburn S., Burstein H., Maniatis T. The human β-interferon gene enhancer is under negative control. Cell. 45:1986;601-610.
8. Goridis C., Brunet J.F. NCAM: structural diversity, function and regulation of expression. Sem. Cell. Biol. 3:1992;189-197.
9. C. Gorman, High efficiency gene transfer into mammalian cells, in: D.M. Glover (Ed.), DNA Cloning, a Practical Approach, IRL Press, Oxford, 1985, pp. 143-190.
10. Hirsch M.-R., Gaugler L., Deagostini-Bazin H., Bally-Cuif L., Goridis C. Identification of positive and negative regulatory elements governing cell-type specific expression of the neural cell adhesion molecule gene. Mol. Cell. Biol. 10:1990;1959-1968.
11. Hirsch M.-R., Valarche I., Deagostini-Bazin H., Pernelle C., Joliot A., Goridis C. An upstream regulatory element of the NCAM promoter contains a binding site for homeodomains. FEBS Lett. 287:1991;197-202.
12. Jones F.S., Holst B.D., Minowa O., De Robertis E.M., Edelman G.M. Binding and transcriptional activation of the promoter for the neural cell adhesion molecule by HoxC6 (Hox-3.3). Proc. Nat. Acad. Sci. U.S.A. 90:1993;6557-6561.
13. Jones F.S., Prediger E.A., Bittner D.A., De Robertis E.M., Edelman G.M. Cell adhesion molecules as targets for Hox genes: neural cell adhesion molecule promoter activity is modulated by cotransfection with Hox-2.5 and -2.4. Proc. Natl. Acad. Sci. U.S.A. 89:1992;2086-2090.
14. Luckow B., Schütz G. CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res. 15:1987;5490.
15. Matsuo I., Kuratani S., Kimura C., Takeda N., Aizawa S. Mouse Otx2 functions in the formation and patterning of rostral head. Genes Dev. 9:1995;2646-2658.
16. Nguyen Ba-Charvet K.T., von Boxberg Y., Guazzi S., Boncinelli E., Godement P. A potential role for the OTX2 homeoprotein in creating early 'highways' for axon extension in the rostral brain. Development. 125:1998;4273-4282.
17. Nothias F., Vernier P., von Boxberg Y., Mirman S., Vincent J.D. Modulation of NCAM polysialylation is associated with morphofunctional modifications in the hypothalamoneurohypophysial system during lactation. Eur. J. Neurosci. 9:1997;1553-1565.
18. Rhinn M., Dierich A., Shawlot W., Behringer R.R., Le Meur M., Ang S.-L. Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification. Development. 125:1998;845-856.
19. Simeone A., Acampora D., Mallamaci A., Stornaiuolo A., D'Apice M.R., Nigro V., Boncinelli E. A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo. EMBO J. 12:1993;2735-2747.
20. Stoykova A., Gotz M., Gruss P., Price J. Pax6-dependent regulation of adhesive patterning, R-cadherin expression and boundary formation in developing forebrain. Development. 124:1997;3765-3777.
21. Valarché I., Tissier-Seta J.P., Hirsch M.R., Martinez S., Goridis C., Brunet J.F. The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype. Development. 119:1993;881-896.