Heat shock protein 90 is responsible for hyperdynamic circulation in portal hypertensive rats

World Journal of Gastroenterology

Volumn 9, Issue 11, 2003, Pages 2544-2547

  Ai, Jian Hua ^a   Yang, Zhen ^a   Qiu, Fa Zu ^a   Zhu, Tong ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; MESSENGER RNA; METHOXAMINE; NITRIC OXIDE; NITROPRUSSIDE SODIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASCITES; CIRCULATION; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG INHIBITION; DRUG POTENTIATION; ENDOTHELIUM; ESOPHAGUS VARICES BLEEDING; GENE OVEREXPRESSION; HEMODYNAMICS; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MESENTERY BLOOD FLOW; NONHUMAN; PORTAL HYPERTENSION; PORTAL VEIN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS INHIBITION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TISSUE PERFUSION; VASOCONSTRICTION; VASODILATATION; VEIN LIGATION; WESTERN BLOTTING;

EID: 0345330166     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v9.i11.2544     Document Type: Article

References (32)

1. Piscaglia F, Zironi G, Gaiani S, Ferlito M, Rapezzi C, Siringo S, Gaia C, Gramantieri L, Bolondi L. Relationship between splanchnic, peripheral and cardiac haemodynamics in liver cirrhosis of different degrees of severity. Eur J Gastroenterol Hepatol 1997; 9: 799-804
2. Bhatal PS, Grossman HJ. Reduction of the increased portal vascular resistance of the isolated perfused cirrhotic rat liver by vasodilators. J Hepatol 1985; 1: 325-337
3. Niederberger M, Gines P, Tsai P, Martin PY, Morris K, Weigert A, McMurtry I, Schrier RW. Increased aortic cyclic guanosine monophosphate concentration in experimental cirrhosis in rats: Evidence for a role of nitric oxide in the pathogenesis of arterial vasodilation in cirrhosis. Hepatology 1995; 21: 1625-1631
4. Cahill PA, Redmond EM, Hodges R, Zhang S, Sitzmann JV. Increased endothelial nitric oxide synthase activity in the hyperemic vessels of portal hypertensive rats. J Hepatol 1996; 25: 370-378
5. Rockey D. The cellular pathogenesis of portal hypertension: Stellate cell contractility, endothelin, and nitric oxide. Hepatology 1997; 25: 2-5
6. Rodriguez-Perez F, Groszmann R. Pharmacologic treatment of portal hypertension. Gastroenterol Clin North Am 1992; 21: 15-40
7. Wiest R, Das S, Cadelina G, Garcia-Tsao G, Milstein S, Groszmann RJ. Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular contractility. J Clin Invest 1999; 104: 1223-1233
8. 2 exchange and liver energy metabolism in hyperdynamic porcine endotoxemia: Effects of iloprost. Intensive Care Med 2000; 26: 1531-1539
9. Laffi G, La Villa G, Pinzani M, Marra F, Gentilini P. Arachidonic acid derivatives and renal function in liver cirrhosis. Semin Nephrol 1997; 17: 530-548
10. Sieber CC, Groszmann RJ. In vitro hyporeactivity to methoxamine in portal hypertensive rats: Reversal by nitric oxide blockade. Am J Physiol 1992; 262 (6Pt1): G996-G1001
11. Sieber CC, Groszmann RJ. Nitric oxide mediates hyporeactivity to vasopressors in mesenteric vessels of portal hypertensive rats. Gastroenterology 1992; 103: 235-239
12. Feron O. Intracellular localization and activation of endothelial nitric oxide synthase. Curr Opin Nephrol Hypertens 1999; 8: 55-59
13. Kubes P. Inducible nitric oxide synthase: A little bit of good in all of us. Gut 2000; 47: 6-9
14. Ros J, Jimenez W, Lamas S, Claria J, Arroyo V, Rivera F, Rodes J. Nitric oxide production in arterial vessels of cirrhotic rats. Hepatology 1995; 21: 554-560
15. Castro A, Jimenez W, Claria J, Ros J, Martinez JM, Bosch M, Arroyo V, Piulats J, Rivera F, Rodes J. Impaired responsiveness to angiotensin II in experimental cirrhosis: Role of nitric oxide. Hepatology 1993; 18: 367-372
16. Weigert AL, Martin PY, Niederberger M, Higa EM, McMurtry IF, Gines P, Schrier RW. Endothelium-dependent vascular hyporesponsiveness without detection of nitric oxide synthase induction in aortas of cirrhotic rats. Hepatology 1995; 22: 1856-1862
17. Wiest R, Shah V, Sessa WC, Groszmann RJ. NO overproduction by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats. Am J Physiol 1999; 276(4 Pt 1): G1043-G1051
18. Gadano AC, Sogni P, Yang S, Cailmail S, Moreau R, Nepveux P, Couturier D, Lebrec D. Endothelial calcium-calmodulin dependent nitric oxide synthase in the in vitro vascular hyporeactivity of portal hypertensive rats. J Hepatol 1997; 26: 678-686
19. Martin PY, Xu DL, Niederberger M, Weigert A, Tsai P, St. John J, Gines P, Schrier RW. Upregulation of endothelial constitutive NOS: A major role in the increased NO production in cirrhotic rats. Am J Physiol 1996; 270(3 Pt 2): F494-F499
20. Hori N, Wiest R, Groszmann RJ. Enhanced release of nitric oxide in response to changes in flow and shear stress in the superior mesenteric arteries of portal hypertensive rats. Hepatology 1998; 28: 1467-1473
21. Nemoto T, Ohara-Nemoto Y, Ota M, Takagi T, Yokoyama K. Mechanism of dimer formation of the 90-kDa heat-shock protein. Eur J Biochem 1995; 233: 1-8
22. Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM. Inhibition of heat shock protein HSP90-pp60-v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci U S A 1994; 91: 8324-8328
23. Garcia-Cardena G, Fan R, Shah V, Sorrentino R, Cirino G, Papapetropoulos A, Sessa WC. Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature 1998; 392: 821-824
24. Chojkier M, Groszmann RJ. Measurement of portal-systemic shunting in the rat by using gamma-labelled microspheres. Am J Physiol 1981; 240: G371-G375
25. Rudic RD, Shesely EG, Maeda N, Smithies O, Segal SS, Sessa WC. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. J Clin Invest 1998; 101: 731-736
26. Sieber CC, Lopez-Talavera JC, Groszmann RJ. Role of nitric oxide in the in vitro splanchnic vascular hyporeactivity in ascitic cirrhotic rats. Gastroenterology 1993; 104: 1750-1754
27. Atucha NM, Shah V, Garcia-Cardena G, Sessa WE, Groszmann RJ. Role of endothelium in the abnormal response of mesenteric vessels in rats with portal hypertension and liver cirrhosis. Gastroenterology 1996; 111: 1627-1632
28. Obermann WM, Sondermann H, Russo AA, Pavletich NP, Hartl FU. In vivo function of HSP90 is dependent on ATP binding and ATP hydrolysis. J Cell Biol 1998; 143: 901-910
29. Picard D, Khursheed B, Garabedian MJ, Fortin MG, Lindquist S, Yamamoto KR. Reduced levels of HSP90 compromise steroid receptor action in vivo. Nature 1990; 348: 166-168
30. Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci U S A 1994; 91: 8324-8328
31. Van Der Straten A, Rommel C, Dickson B, Hafen E. The heat shock protein 83(HSP83) is required for Raf-mediated signaling in Drosphila. EMBO J 1997; 16: 1961-1969
32. Imai J, Yahara I. Role of HSP90 in salt stress tolerance via stabilization and regulation of calcineurin. Mol Cell Biol 2000; 20: 9262-9270