Simple procedures for blinded sample size adjustment that do not affect the type I error rate

Statistics in Medicine

Volumn 22, Issue 23, 2003, Pages 3571-3581

  Kieser, Meinhard ^a,b   Friede, Tim ^c  

^a DR WILLMAR SCHWABE GMBH AND CO KG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c LANCASTER UNIVERSITY   (United Kingdom)

Author keywords

Clinical trial; Internal pilot study; Sample size adjustment; Two stage design

Indexed keywords

BENZODIAZEPINE; KAVA; KAVAKAVA SPECIAL EXTRACT WS; PLACEBO;

ANALYTIC METHOD; ANALYTICAL ERROR; ANXIETY DISORDER; ARTICLE; BIOSTATISTICS; CALCULATION; CLINICAL STUDY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; HUMAN; MEDICINAL PLANT; PLANNING; PROBABILITY; RANDOMIZED CONTROLLED TRIAL; SAMPLE SIZE; SATISFACTION; SIMULATION; STATISTICAL ANALYSIS;

ANXIETY DISORDERS; CLINICAL TRIALS; HUMANS; KAVA; PLANT EXTRACTS; RESEARCH DESIGN; SAMPLE SIZE;

EID: 0345329168     PISSN: 02776715     EISSN: None     Source Type: Journal    
DOI: 10.1002/sim.1585     Document Type: Article

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