Hepatitis C virus core protein transactivates the inducible nitric oxide synthase promoter via NF-κB activation

Antiviral Research

Volumn 60, Issue 2, 2003, Pages 117-124

  De Lucas, Susana ^a   Bartolomé, Javier ^a   Amaro, María José ^a   Carreño, Vicente ^a  

^a Fund El Estud Las Hepat Virales   (Spain)

Author keywords

HCV core protein; NF B; Nitric oxide

Indexed keywords

CORE PROTEIN; DNA; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; NITRIC OXIDE SYNTHASE;

BINDING SITE; CELL STRAIN HEPG2; COMPLEX FORMATION; CONFERENCE PAPER; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSFECTION; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

HEPATITIS C VIRUS;

EID: 0345306186     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.antiviral.2003.08.006     Document Type: Conference Paper

References (41)

1. Amaro M.J., Bartolomé J., Carreño V. Hepatitis B virus X protein transactivates the inducible nitric oxide synthase promoter. Hepatology. 29:1999;915-923.
2. Amin A.R., Patel R.N., Thakker G.D., Lowenstein C.J., Attur M.G., Abramson S.B. Post-transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxicycline and chemically modified tetracyclines. FEBS. 410:1997;259-264.
3. Andus T., Bauer J., Gerok W. Effects of cytokines on the liver. Hepatology. 13:1991;364-375.
4. Camels S., Hainaut P., Ohshima H. Nitric oxide induces conformational and functional modifications of wild-type p53 tumor suppressor protein. Cancer Res. 57:1997;3365-3369.
5. Chen C.-H., Hwang L.-H., Lee Y.-H.W. Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-β receptor modulates the signal pathway of the lymphotoxin-β receptor. J. Virol. 71:1997;9417-9426.
6. García-Monzón C., Majano P.L., Zubia I., Sanz P., Apolinario A., Moreno-Otero R. Intrahepatic accumulation of nitrotyrosine in chronic viral hepatitis is associated with histological severity of liver disease. J. Hepatol. 32:2000;331-338.
7. Gonzalez-Peralta R.P., Davis G.L., Lau J.Y. Pathogenic mechanism of hepatocelular damage in chronic hepatitis C virus infection. J. Hepatol. 21:1994;255-259.
8. Guidotti L.G., McClary H., Loudis J.M., Chisari F.V. Nitric oxide inhibits hepatitis B virus replication in the livers of transgenic mice. J. Exp. Med. 191:2000;1247-1252.
9. Hoofnagle J.H. Hepatitis C: the clinical spectrum of disease. Hepatology. 26:1997;15S-20S.
10. Jaiswal M., LaRusso N.F., Burgart L.J., Gores G.J. Immflamatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by nitric oxide-dependent mechanism. Cancer Res. 60:2001;184-190.
11. Karupiah G., Xie Q., Mark R., Buller L., Nathan C., Duartet C., MacMicking J.D. Inhibition of viral replication by interferon gamma induced nitric oxide synthase. Science. 261:1993;1445-1448.
12. Kato N., Yoshida H., Ono-Nita S.K., Kato J., Goto T., Otsuka M., Lan K.-H., Matsushima K., Shiratori Y., Omata M. Activation of intracellular signaling by Hepatitis B and C viruses: C-viral core is the most potent signal inducer. Hepatology. 32:2000;405-412.
13. Kenneth D.C. Evidence for an antiviral effect of nitric oxide. J. Clin. Invest. 91:1993;2446-2452.
14. Kim Y.M., Talanian R.V., Billiar T. Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms. J. Biol. Chem. 272:1997;31138-31148.
15. 6-methylguanine-DNA methyltransferase. Carcinogenesis. 15:1994;443-447.
16. Lyons C.R. The role of nitric oxide in inflammation. Adv. Immunol. 60:1995;323-371.
17. Majano P.L., García-Monzón C., López-Cabrera M., Lara-Pezzi E., Fernández-Ruiz E., García-Iglesias C., Borque M.J., Moreno-Otero R. Inducible oxide nitric synthase expression in chronic viral hepatitis. Evidence for a virus-induced gene upregulation. J. Clin. Invest. 101:1998;1343-1352.
18. Majano P.L., Lara-Pezzi E., López-Cabrera M., Apolinario A., Moreno-Otero R., García-Monzón C. Hepatitis B virus X protein transactivates inducible oxide nitric synthase gene promoter through the proximal nuclear factor κb-binding site: evidence that cytoplasmic localization of X protein is essential for gene transactivation. Hepatology. 34:2001;1218-1224.
19. McCaughan G.W., Napoli J., McGuinness P., Bishop G.A. T1 versus T2 cytokine responses in chronic HCV: implications for mechanisms of liver injury. Viral Hepat. Rev. 3:1997;129-142.
20. Mihm S., Fayyazi A., Ramadori G. Hepatic expression of inducible oxide nitric synthase transcripts in chronic hepatitis C virus infection: relation to hepatic viral load and liver injury. Hepatology. 26:1997;451-458.
21. Moncada S., Palmer R.M.J., Higgs E.A. Nitric oxide physiology and pharmacology. Pharmacol. Rev. 43:1991;109-142.
22. Moriya K., Fujie H., Shintani Y., Yotsuyanagi H., Tsutsumi T., Ishibashi K., Matsuura Y., Kimura S., Miyamura T., Koike K. The core protein of hepatitis C virus core protein induces hepatocellular carcinoma in transgenic mice. Nat. Med. 4:1998;1065-1067.
23. Nathan C., Xie Q.W. Nitric oxide synthases: role, tolls and controls. Cell. 78:1994;915-928.
24. Nguyen T., Brunson D., Crespi C.L., Penman B.W., Wishnock J.S., Tannenbaum S.R. DNA damage and mutation in human cells exposed to nitric oxide in vitro. Proc. Natl. Acad. Sci. U.S.A. 89:1992;3030-3040.
25. Nunokawa Y., Ishida N., Tanaka S. Promoter analysis of human inducible oxide nitric synthase gene associated with cardiovascular homeostasis. Biochem. Biophys. Res. Commun. 200:1994;802-807.
26. Nussler A.K., Di Silvio M., Billiar T.R., Hoffman R.A., Geller D.A., Selby R., Madariaga J., Simmons R.L. Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin. J. Exp. Med. 176:1992;261-264.
27. Ray R.B., Lagging L.M., Meyer K., Steele R., Ray R. Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein. Virus Res. 37:1995;209-220.
28. Ray R.B., Meyer K., Ray R. Hepatitis C virus core protein promotes immortalization of primary human hepatocytes. Virology. 271:2000;197-204.
29. Rehermann B., Chisari F.V. Cell mediated immune response to the hepatitis C virus. Curr. Top. Microbiol. Immunol. 242:2000;299-325.
30. Saito I., Miyamura T., Harada H., Katayama T., Kikuchi S., Watanabe Y., Koi S., Onji M., Ohta Y., Choo Q., Houghton M., Kuo G. Hepatitis C virus infection is associated with the development of hepatocelular carcinoma. Proc. Natl. Acad. Sci. U.S.A. 87:1990;6547-6549.
31. Santolini E., Migliaccio G., La Monica N. Biosynthesis and biochemical properties of the hepatitis C virus core protein. J. Virol. 68:1994;3631-3641.
32. Schweyer S., Mihm S., Radzun H.J., Hartmann H., Fayyazi A. Liver infiltrating T lymphocytes express interferon γ and inducible nitric oxide synthase in chronic hepatitis C infection. Gut. 46:2000;255-259.
33. Shrivastava A., Manna S.K., Ray R., Aggarwal B.B. Ectopic expression of hepatitis C virus core protein differentially regulates nuclear transcription factors. J. Virol. 72:1998;9722-9728.
34. Stamler J.S. Redox signaling: nitrosylation and related target interactions of nitric oxide. Cell. 78:1994;931-936.
35. Tai D., Tsai S., Chen Y., Chuang Y., Peng C., Sheen I., Yeh C.T., Chang K.S., Huang S.N., Kuo G.C., Liaw Y.F. Activation of nuclear factor κB in hepatitis C virus infection: implication for pathogenesis and hepatocarcinogenesis. Hepatology. 31:2000;656-664.
36. Tsuchihara K., Hijikata M., Fukuda K., Kuroki T., Yamamoto N., Shimotohno K. Hepatitis C virus core protein regulates cell growth and signal transduction pathway transmitting growth stimuli. Virology. 258:1999;100-107.
37. Xie Q.W., Kasiwabara Y., Nathan C. Role of transcription factor NF-κB/rel in induction of nitric oxide synthase. J. Biol. Chem. 269:1994;4705-4708.
38. Yasui K., Wakita T., Tsukiyama-Kohara K., Funahashi S.-I., Ichikawa M., Kajita T., Moradpour D., Wands J.R., Kohara M. The native form and maturation process of hepatitis C virus core protein. J. Virol. 72:1998;6048-6055.
39. You L.-R., Chen C.-M., Lee Y.-H.W. Hepatitis C virus core protein enhances NF-κB signal pathway triggering by lymphotoxin-beta receptor ligand and tumor necrosis factor alpha. J. Virol. 73:1999;1672-1681.
40. Zhao X., Jie O., Li H., Xie J., Giles T.D., Greenberg S.S. Ethanol inhibits inducible nitric oxide synthase transcription and post-transcriptional proceses in vivo. Alcohol. Clin. Exp. Res. 21:1997;1246-1256.
41. Zhu N., Khoshnan A., Schneider R., Matsumoto M., Dennert G., Ware C., Lai M.M.C. Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis. J. Virol. 72:1998;3691-3697.