Adducts of acrylonitrile with hemoglobin in nonsmokers and in participants in a smoking cessation program

Chemical Research in Toxicology

Volumn 12, Issue 10, 1999, Pages 869-873

  Licea Pérez, Hermes ^a   Segerbäck, Dan ^a   Osterman Golkar, Siv ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLONITRILE; CARCINOGEN; HEMOGLOBIN; TOBACCO SMOKE;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EXPOSURE; HYDROLYSIS; METHYLATION; NONHUMAN; PASSIVE SMOKING; SMOKING CESSATION; SMOKING HABIT;

ACRYLONITRILE; ADULT; CALIBRATION; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEMOGLOBINS; HUMANS; INFANT, NEWBORN; PLANTS, TOXIC; PREGNANCY; REFERENCE STANDARDS; SMOKING; SMOKING CESSATION; TOBACCO, SMOKELESS;

NICOTIANA TABACUM;

EID: 0345281588     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx9900728     Document Type: Article

References (17)

1. Osterman-Golkar, S., Ehrenberg, L., Segerbäck, D., and Hällström, I. (1976) Evaluation of genetic risks of alkylating agents. II. Haemoglobin as a dose monitor. Mutat. Res. 34, 1-10.
2. Bryant, M. S., and Osterman-Golkar, S. (1991) Hemoglobin adducts as dosimeters of exposure to DNA-reactive chemicals. CIIT Activities 11, 1-9.
3. Filser, J. G., Denk, B., Törnqvist, M., Kessler, W., and Ehrenberg, L. (1992) Pharmacokinetics of ethylene in man; body burden with ethylene oxide and hydroxyethylation of hemoglobin due to endogenous and environmental ethylene. Arch. Toxicol. 66, 157-163.
4. Törnqvist, M., Svartengren, M., and Ericsson, C. H. (1992) Methylations in hemoglobin from monozygotic twins discordant for cigarette smoking: Hereditary and tobacco-related factors. Chem.-Biol. Interact. 82, 91-98.
5. Bergmark, E. (1997) Hemoglobin adducts of acrylamide and acrylonitrile in laboratory workers, smokers and nonsmokers. Chem. Res. Toxicol. 10, 78-84.
6. Bryant, M. S., Skipper, P. L., Tannenbaum, S. R., and Maclure, M. (1987) Hemoglobin adducts of 4-aminobiphenyl in smokers and nonsmokers. Cancer Res. 47, 602-608.
7. Myers, S. R., Spinnato, J. A., Pinori-Godly, M. T., Cook, C., Boles, B., and Rodgers, G. C. (1996) Characterization of 4-aminobiphenyl-hemoglobin adducts in maternal and fetal blood samples. J. Toxicol. Environ. Health 47, 553-566.
8. Hammond, S. K., Coghlin, J., Gann, P. H., Paul, M., Taghizadeh, K., Skipper, P. L., and Tannenbaum, S. R. (1993) Relationship between environmental tobacco smoke exposure and carcinogen-hemoglobin adduct levels in non-smokers. J. Natl. Cancer Inst. 85, 474-478.
9. Carmella, S. G., Kagan, S. S., Kagan, M., Foiles, P. G., Palladino, G., Quart, A. M., Quart, E., and Hecht, S. S. (1990) Mass spectrometric analysis of tobacco-specific nitrosamine hemoglobin adducts in snuff dippers, smokers and nonsmokers. Cancer Res. 50, 5438-5445.
10. Maltoni, C., Ciliberti, A., Cotti, G., and Perino, G. (1987) Experimental Research on Acrylonitrile Carcinogenesis, Princeton Scientific Publishing Co., Princeton, NJ.
11. International Agency for Research on Cancer (1985) Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans: Tobacco Smoking, Vol. 38, International Agency for Research on Cancer, Lyon, France.
12. Osterman-Golkar, S. M., MacNeela, J. P., Turner, M. J., Walker, V. E., Swenberg, J. A., Jenkins Sumner, S., Youtsey, N., and Fennell, T. R. (1994) Monitoring exposure to acrylonitrile using adducts to N-terminal valine in hemoglobin. Carcinogenesis 15, 2701-2707.
13. Tavares, R., Borba, H., Monteiro, M., Proença, M. J., Lynce, N., Rueff, J., Bailey, E., Sweetman, G. M. A., Lawrence, R. M., and Farmer, P. B. (1996) Monitoring of exposure to acrylonitrile by determination of N-(2-cyanoethyl)valine at the N-terminal position of haemoglobin. Carcinogenesis 17, 2655-2660.
14. Licea Pérez, H., Cheong, H. K., Yang, J. S., and Osterman-Golkar, S. (1999) Simultaneous analysis of hemoglobin adducts of acrylamide and glycidamide by gas chromatography - mass spectrometry. Anal. Biochem. (in press).
15. Fennell, T. R., Sumner, S. C. J., and Walker, V. E. (1992) A model for the formation and removal of hemoglobin adducts. Cancer Epidemiol., Biomarkers Prev. 1, 213-219.
16. Maclure, M., Bryant, M. S., Skipper, P. L., and Tannenbaum, S. R. (1990) Decline of the hemoglobin adduct of 4-aminobiphenyl during withdrawal from smoking. Cancer Res. 50, 181-184.
17. Tates, A. D., Boogaard, P. J., Darroudi, F., Natarajan, A. T., Caubo, M. E., and van Sittert, N. J. (1995) Biological effect monitoring in industrial workers following incidental exposure to high concentrations of ethylene oxide. Mutat. Res. 329, 63-77.