Simple and sensitive liquid chromatography/tandem mass spectrometry method for the determination of diazepam and its major metabolites in rat cerebrospinal fluid

Rapid Communications in Mass Spectrometry

Volumn 17, Issue 6, 2003, Pages 519-525

  Wang, Junying ^a   Shen, Xiaolan ^a   Fenyk Melody, Judy ^a   Pivnichny, James V ^a   Tong, Xinchun ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; BIOMOLECULES; BRAIN; CALIBRATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; RATS;

ANALYTES; LC-MS-MS; LINEAR CALIBRATION; LOWER LIMIT OF QUANTIFICATIONS; OXAZEPAM; SAMPLE VOLUME; SENSITIVE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; SIMPLE++; SMALL SAMPLES; STATUS EPILEPTICUS;

CEREBROSPINAL FLUID;

DIAZEPAM; DRUG METABOLITE; NORDAZEPAM; OXAZEPAM; TEMAZEPAM;

ANIMAL EXPERIMENT; ARTICLE; CALIBRATION; CEREBROSPINAL FLUID; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG METABOLISM; EPILEPTIC STATE; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; RAT; TANDEM MASS SPECTROMETRY;

EID: 0345268639     PISSN: 09514198     EISSN: None     Source Type: Journal    
DOI: 10.1002/rcm.942     Document Type: Article

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