Inhibition of tumor invasiveness by 1α,25-dihydroxy-vitamin D3 coupled to a decline in protein kinase A activity and an increase in cytoskeletal organization

Clinical and Experimental Metastasis

Volumn 15, Issue 2, 1997, Pages 102-110

  Young, M Rita I ^a,b   Lozano, Yvonne ^a  

^a HINES VA HOSPITAL   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

1 ,25 dihydroxyvitamin D3; cytoskeleton; F actin; invasion; protein kinase A

Indexed keywords

CALCITRIOL; CYCLIC AMP DEPENDENT PROTEIN KINASE; F ACTIN; MATRIGEL;

ANIMAL CELL; ARTICLE; CELL INVASION; CONTROLLED STUDY; CYTOSKELETON; LEWIS CARCINOMA; MOUSE; NONHUMAN;

ANIMALS; CALCITRIOL; CARCINOMA, LEWIS LUNG; CELL MOVEMENT; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOSKELETON; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; NEOPLASM INVASIVENESS; PHENOTYPE; VIMENTIN;

EID: 0030966969     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1018492525027     Document Type: Article

References (43)

1. Bernstein LR and Liotta LA, 1994, Molecular mediators of interactions with extracellular matrix components in metastasis and angiogenesis. Curr Opin Oncol, 6, 106-13.
2. Rosen EM, Knesel J, Goldberg ID, et al. 1994, Scatter factor modulates the metastatic phenotype of the EMT6 mouse mammary tumor. Int J Cancer, 57, 706-14.
3. You J, Miele ME, Dong C and Welch DR, 1995, Suppression of human melanoma metastasis by introduction of chromosome 6 may be partially due to inhibition of motility, but not to inhibition of invasion. Biochem Biophys Res Commun, 208, 476-84.
4. Veatch AL, Carson LF and Ramakrishnan S, 1995, Phenotypic variations and differential migration of NIH:OVCAR-3 ovarian carcinoma cells isolated from athymic mice. Clin Exp Metastasis, 13, 165-72.
5. Mohler JL, Broskie EN, Ranparia DJ, Sharief Y, Coleman WB and Smith GJ, 1992, Cancer cell motility-inhibitory protein in the Dunning adenocarcinoma model. Cancer Res, 52, 2349-52.
6. Shimokawa-Kuroki R, Sadano H and Taniguchi S, 1994, A variant actin (beta m) reduces metastasis of mouse B16 melanoma. Int J Cancer, 56, 689-97.
7. Sadano H, Shimokawa-Kuroki R and Taniguchi S, 1994, Intracellular localization and biochemical function of variant beta-actin, which inhibits metastasis of B16 melanoma. Japanese J Cancer Res, 85, 735-43.
8. Pokorna E, Jordan PW, O'Neill CH, Zicha D, Gilbert CS and Vesely P, 1994, Actin cytoskeleton and motility in rat sarcoma cell populations with different metastatic potential. Cell Motility & the Cytoskeleton, 28, 25-33.
9. Helige C, Smolle J, Zellnig G, et al. 1993, Inhibition of K1735-M2 melanoma cell invasion in vitro by retinoic acid. Clin Exp Met, 11, 409-18.
10. Lakshmi MS, Parker C and Sherbet GV, 1993, Metastasis and associated MTS1 and NM23 genes affect tubulin polymerisation in B16 melanomas: a possible mechanism of their regulation of metastatic behaviour of tumours. Anticancer Res, 13, 299-303.
11. Button E, Shapland C and Lawson D, 1995, Actin, its associated proteins and metastasis. Cell Motil Cytoskel, 30, 247-51.
12. Imai K, Kumagai S, Nakagawa K, Yamamoto E, Nakanishi I and Okada Y, 1995, Immunolocalization of desmoglein and intermediate filaments in human oral squamous cell carcinomas. Head & Neck, 17, 204-12.
13. Scott G and Liang H, 1995, pp125FAK in human melanocytes and melanoma: expression and phosphorylation. Exp Cell Res, 219, 197-203.
14. Trachsel S and Keller HU, 1995, Selective responses (actin polymerization, shape changes, locomotion, pinocytosis) to the PKC inhibitor Ro 31-8220 suggest that PKC discriminately regulates functions of human blood lymphocytes. J Leuko Biol, 57, 587-91.
15. Goldenring JR, Vallano ML and DeLorenzo RJ, 1985, Phosphorylation of microtubule-associated protein 2 at distinct sites by calmodulin-dependent and cyclic-AMP-dependent kinases. J Neurochem, 45, 900-5.
16. 2+/calmodulin-dependent protein kinase II. J Neurosci Res, 34, 642-7.
17. Lamb NJC, Fernandez A, Feramisco JR and Welch WJ, 1989, Modulation of vimentin containing intermediate filament distribution and phosphorylation in living fibroblasts by the cAMP-dependent protein kinase. J Cell Biol, 108, 2409-22.
18. Huang TJ, Lee TT, Lee WC, Lai YK, Yu JS and Yang SD, 1994, Autophosphorylation-dependent protein kinase phosphorylates Ser25, Ser38, Ser65, Ser71, and Ser411 in vimentin and thereby inhibits cytoskeletal intermediate filament assembly. J Prot Chem, 13, 517-25.
19. Tang DG, Grossi IM, Tang KQ, Diglio CA and Honn KV, 1995, Inhibition of TPA and 12(S)-HETE-stimulated tumor cell adhesion by prostacyclin and its stable analogs: rationale for their antimetastatic effects. Int J Cancer, 60, 418-25.
20. Ziegler A, Knesel J, Fabbro D and Nagamine Y, 1991, Protein kinase C down-regulation enhances cAMP-mediated induction of urokinase-type plasminogen activator mRNA in LLC-PK1 cells. J Biol Chem, 266, 21067-74.
21. 2-producing nonmetastatic Lewis lung carcinoma variants. Cancer Res, 50, 2973-8.
22. Young MRI, Lozano Y, Djordjevic A and Maier D, 1993, Protein phosphatases limit tumor motility. Int J Cancer, 54, 1036-41.
23. Maier GD, Vellody K, Meisinger J, Djordjevic A, Lozano Y and Young MRI, 1996, Protein kinase A regulates Lewis lung carcinoma adherence to extra-cellular matrix components and spontaneous metastasis. Clin Exp Metastasis, in press.
24. Young MRI, Montpetit M, Lozano Y, et al. 1995, Lewis lung carcinoma transfectants that either over-express or have defective protein kinase A activity have a respective high or low capacity to invade and metastasize in vivo. Int J Cancer, 64, 104-9.
25. 2-stimulated migration of Lewis lung carcinoma clones. Int J Cancer, 49, 150-5.
26. 3 reduces tumor motility and metastasis. Invasion Metastasis, 13, 169-77.
27. Young MRI, Young ME, Lozano Y and Bagash JM, 1992, Activation of protein kinase A increases the in vitro invasion, migration, and adherence to reconstituted basement membrane by Lewis lung carcinoma tumor cells. Invasion Metastasis, 12, 253-63.
28. Young MRI, Charboneau S, Lozano Y, Djordjevic A and Young ME, 1994, Activation of the protein kinase A signal transduction pathway by granulocytemacrophage colony-stimulating factor or by genetic manipulation reduces cytoskeletal organization in Lewis lung carcínoma variants. Int J Cancer, 54, 446-51.
29. McKnight GS, Uhler MD, Clegg CH, Correll LA and Cadd GG, 1988, Application of molecular genetic techniques to the cAMP-dependent protein kinase system. Meth Enzymol, 159, 299-311.
30. Maier GD, Wright MA, Lozano Y, Djordjevic A, Matthews JP and Young MRI, 1995, Regulation of cytoskeletal organization in tumor cells by protein phosphatases -1 and -2A. Int J Cancer, 61, 51-4.
31. Babai F and Royal A, 1994, Rat myoblastic sarcoma cell lines. A model for the study of invasion, metastasis, and myogenic differentiation. Lab Invest, 70, 907-15.
32. Gutierrez LM, Quintanar JL, Rueda J, Viniegra S and Reig JA, 1995. The protein phosphatase inhibitor calyculin-A affects catecholamine secretion and granular distribution in cultured adrenomedullary chromaffin cells. Eur J Cell Biol, 68, 88-95.
33. Hannun YA and Linardic CM. 1993, Sphingolipid breakdown products: anti-proliferative and tumor-suppressor lipids. [Review] Biochim Biophys Acta. 1154, 223-36.
34. 2-ceramide. J Biol Chem. 270, 12808-13.
35. Wolff RA, Dobrowsky RT, Bielawska A, Obeid LM and Hannun YA, 1994, Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J Biol Chem, 269, 19605-9.
36. Dohrowsky RT, Kamibayashi C, Mumby MC and Hannun YA, 1993, Ceramide activates heterotrimeric protein phosphatase 2A. J Biol Chem, 268, 15523-30.
37. 3-induced HL-60 cell differentiation. J Biol Chem, 265, 15823-31.
38. 3 in HL-60 cells. Role in cell differentiation. J Biol Chem, 264, 19076-80.
39. 3 alters the effect of cAMP in thyroid cells by increasing the regulatory subunit type IIβ of the cAMP-dependent protein kinase. J Biol Chem, 269, 32233-32238.
40. 3 attenuates adenylyl cyclase activity in rat thyroid cells: reduction of thyrotropin receptor number and increase in guanine nucleotide-binding protein Gi-2α. Endocrinology, 135, 595-602.
41. Colston KW, Makay AG, James SY, Binderup L and Chander Sand Coombes RC, 1992, EB1089: a new vitamin D analogue that inhibits the growth of breast cancer cells in vivo and in vitro. Biochem Pharmacol, 44, 2273-80.
42. 3. Cancer Res, 54, 4057-64.
43. Studzinski GP and Moore DC, 1995, Sunlight - Can it prevent as well as cause cancer? Cancer Res, 55, 4014-22.