Separation of the enantiomers of ibuprofen and its major phase I metabolites in urine using capillary electrophoresis

Electrophoresis

Volumn 19, Issue 3, 1998, Pages 455-460

  Bjørnsdottir, Inga ^a   Kepp, Dorte Rode ^a   Tjørnelund, Jette ^a   Hansen, Steen Honoré ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Capillary electrophoresis; Chiral separation; Dextrin 10; Heptakis (2,3,6 tri O methyl) cyclodextrin; Ibuprofen

Indexed keywords

BODY FLUIDS; CHIRALITY; CYCLODEXTRINS; ELECTROOSMOSIS; ENANTIOMERS; GLUCOSE; METABOLITES;

2(N-MORPHOLINO) ETHANESULFONIC ACID; ACID BUFFERS; CHIRAL SELECTOR; CHIRAL SEPARATIONS; DEXTRIN 10; HEPTAKI (2,3,6-TRI-O-METHYL)-Β-CYCLODEXTRIN; IBUPROFEN; METHYL-Β-CYCLODEXTRIN; PHASE I; URINE SAMPLE;

CAPILLARY ELECTROPHORESIS;

2 CARBOXYIBUPROFEN; 2 HYDROXYIBUPROFEN; DRUG METABOLITE; IBUPROFEN; NYFEN; UNCLASSIFIED DRUG;

ARTICLE; CAPILLARY ELECTROPHORESIS; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG METABOLISM; DRUG PURIFICATION; ENANTIOMER; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; TECHNIQUE; URINALYSIS;

EID: 0345214534     PISSN: 01730835     EISSN: None     Source Type: Journal    
DOI: 10.1002/elps.1150190316     Document Type: Article

References (20)

1. Davies, E. F., Avery, G. S., Drugs 1971, 2, 416-446.
2. Brooks, C. D., Schmid, F. R., Biundo, J., Blau, S., Gonzales-Alcover, R., Gowans, J. D. C., Hurd, E., Partidge, R. E. H., Tarpley, E. L., Rheumatol. Phys. Med., Suppl. 1970, 48-63.
3. Adams, S. S., McCullough, K. F., Nicholson, J. S., Arch. Int. Pharmacodyn. 1969, 178, 115-129.
4. Jamali, F., Wainer, I. W. (Eds.), Drug Stereochemistry, Marcel Dekker Inc., New York 1993, pp. 375-384.
5. Adams, S. S., Bresloff, P., Mason, C. G., J. Pharm. Pharmacol. 1976, 28, 256-257.
6. Hutt, A. J., Caldwell, J., J. Pharm Pharmacol. 1983, 35, 683-704.
7. Kaiser, D. J., Vangeissen, G. J., Reischer, R. J., Wechter, W. J., J. Pharm. Sci. 1976, 65, 269-273.
8. Tracy, T. S., Hall, S. D., Drug Metabol. Dispos. 1992, 20, 322-327.
9. Kepp, D. R., Sidelmann, U. G., Hansen, S. H., Pharmac. Res. 1997, 14, 676-680.
10. Guttman, A., Electrophoresis 1995, 16, 1900-1905.
11. Fanali, S., Aturki, Z., J. Chromatogr. A 1995, 694, 297-305.
12. Rawajee, Y. Y., Williams, R. L., Vigh, G., J. Chromatogr. A 1994, 680, 599-607.
13. Soini, H., Stefansson, M., Riekkola, M. L., Novotny, M. V., Anal. Chem. 1994, 66, 3477-3484.
14. Quang, C., Khaledi, M. G., J. High Res. Chromatogr. 1994, 17, 609-612.
15. D'Hulst, A., Verbeke, N., Electrophoresis 1994, 15, 854-863.
16. Sun, P., Wu, N., Barker, G., Hartwick, R. A., J. Chromatogr. 1993, 648, 475-480.
17. Rawjee, Y. Y., Staerk, D. U., Vigh, G., J. Chromatogr. 1993, 635, 291-306.
18. D'Hulst, A, Verbeke, N., J. Chromatogr. 1992, 608, 275-287.
19. Córdova, E., Gao, J., Whitesides, G. M., Anal. Chem. 1997, 69, 1370-1379.
20. Kaneta, T., Tanaka, S., Taga, M., J. Chromatogr.1993, 653, 313-319.