Isolation and characterization of major phase I and II metabolites of ibuprofen

Pharmaceutical Research

Volumn 14, Issue 5, 1997, Pages 676-680

  Kepp, Dorte R ^a   Sidelmann, Ulla G ^a   Hansen, Steen H ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

HPLC; Ibuprofen; Metabolites; NMR

Indexed keywords

DRUG METABOLITE; IBUPROFEN;

ARTICLE; CHROMATOGRAPHY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG METABOLISM; DRUG PURITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SOLID PHASE EXTRACTION;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; GLUCURONATES; HUMANS; IBUPROFEN; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE;

EID: 0030908333     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012125700497     Document Type: Article

References (12)

1. G. F. Lockwood and J. G. Wagner. J. Chromatogr. 232:335-343 (1982).
2. C. J. W. Brooks and M. T. Gilbert. J. Chromatogr. 99:541-551 (1974).
3. C. Giachetti, G. Zanolo, and S. Canali. J. High Resolut. Chromatogr. Chromatogr. Commun. 8:465-468 (1985).
4. B. Chai, P. E. Minkler, and C. L. Hoppel. J. Chromatogr. 430:93-101 (1988).
5. A. Shah and D. Jung. J. Chromatogr. 378:232-236 (1986).
6. R. F. N. Mills, S. S. Adams, E. E. Cliffe, W. Dickinson, and Z. S. Nicholson. Xenobiotica 3:589-598 (1973).
7. H. Spahn and P. Langguth. Pharm. Res. 7:1262-1268 (1990).
8. M. El Mouelhi, H. W. Ruelius, C. Fenslau, and D. M. Dulik. Drug Melab. Dispos. 15:767-772 (1987).
9. M. Spraul, M. Hofmann, P. Dvortsak, J. K. Nicholson, and I. D. Wilson. Anal. Chem. 65:327-330 (1993).
10. M. Spraul, M. Hofmann, P. Dvortsak, J. K. Nicholson, and I. D. Wilson. J. Pharm. Biomed. Anal. 10:601-605 (1992).
11. I. D. Wilson and J. K. Nicholson. Anal. Chem. 59:2830-2832 (1987).
12. I. D. Wilson, F. Y. K. Ghauri, C. R. Blackledge, and J. K. Nicholson. Anal. Proc. 28:217-223 (1991).