Partially differentiated ex vivo expanded cells accelerate hematologic recovery in myeloablated mice transplanted with highly enriched long-term repopulating stem cells

Blood

Volumn 88, Issue 9, 1996, Pages 3642-3653

  Szilvassy, Stephen J ^a,b   Weller, Kevin P ^a   Chen, Ben ^a   Juttner, Christopher A ^a   Tsukamoto, Ann ^a   Hoffman, Ronald ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 3; INTERLEUKIN 6; STEEL FACTOR;

ALLOTRANSPLANTATION; ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL REGENERATION; CELL TRANSPLANTATION; COLONY FORMING UNIT S; CONTROLLED STUDY; CYTOPENIA; ERYTHROCYTE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; LEUKOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE;

EID: 0029858420     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.9.3642.bloodjournal8893642     Document Type: Article

References (59)

1. Wu AM, Till JE, Siminovitch L, McCulloch EA: Cytological evidence for a relationship between normal hemopoietic colony-forming cells and cells of the lymphoid system. J Exp Med 127:455, 1968
2. Abramson S, Miller RG, Phillips RA: The identification in adult bone marrow of pluripotent and restricted stem cells of the myeloid and lymphoid systems. J Exp Med 145:1567, 1977
3. V mice. Cell 42:71, 1985
4. Keller G, Paige C, Gilboa E, Wagner EF: Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors. Nature 318:149, 1985
5. Lemischka IR, Raulet DH, Mulligan RC: Developmental potential and dynamic behaviour of hematopoietic stem cells. Cell 45:917, 1986
6. Brenner MK, Rill DR, Moen RC, Krance RA, Mirro J Jr, Anderson WF, Ihle JN: Gene-marking to trace origin of relapse after autologous bone-marrow transplantation. Lancet 341:85, 1993
7. + cells present in autologous transplants of chronic myelogenous leukemia (CML) contribute to relapse after autologous bone marrow in CML. Blood 88:3068, 1994
8. + marrow cells in patients with breast cancer or neuroblastoma. Blood 77:1717, 1991
9. Shpall EJ, Jones RB, Johnston C, Hami L, Stemmer S, Affronti ML, Curiel T, Berenson RJ: Purified CD34 positive (+) marrow progenitor cells provide effective reconstitution for breast cancer (Ca) and non-Hodgkin's lymphoma (NHL) patients receiving high dose chemotherapy with autologous bone marrow support (HDC/ABMS): Recombinant granulocyte colony stimulating factor (G-CSF) accelerates hematopoietic recovery. Proc Am Assoc Clin Oncol 11:59a, 1992
10. Kohler G, Brugger W, Schaefer HE, Kanz L: Expression of CD34 stem cell antigen on tumor cells. Blood 84:497a, 1994 (abstr, suppl 1)
11. + stem cells do not contain clonal myeloma cells. Blood 86:381, 1995
12. Wessman M, Schnell J, Van Den Berg D, Kshirsagar B, Sriti Z, Reading C: Fluorescent detection of metastatic breast cancer cells in bone marrow and mobilized peripheral blood by immunofluorescence and by high speed flow cytometry. Blood 86:233a, 1995 (abstr, suppl 1)
13. Gazitt Y, Tian E, Barlogie B, Reading CL, Vesole DH, Jagannath S, Schnell J, Hoffman R, Tricot G: Differential mobilization of myeloma cells and normal hematopoietic stem cells in multiple myeloma after treatment with cyclophosphamide and granulocyte-macrophage colony-stimulating factor. Blood 87:805, 1996
14. Sutherland HJ, Eaves CJ, Eaves AC, Dragowska W, Lansdorp PM: Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro. Blood 74:1563, 1989
15. - progenitor cells. Blood 77:1218, 1991
16. Baum CM, Weissman IL, Tsukamoto AS, Buckle AM, Peault B: Isolation of a candidate human hematopoietic stem-cell population. Proc Natl Acad Sci USA 89:2804, 1992
17. Craig W, Kay R, Cutler RL, Lansdorp PM: Expression of Thy-1 on human hematopoietic progenitor cells. J Exp Med 177:1331, 1993
18. Bender JG, To LB, Williams S, Schwartzberg LS: Defining a therapeutic dose of peripheral blood stem cells. J Hematother 1:329, 1992
19. To LB, Roberts MM, Haylock DN, Dyson PG, Branford AL, Thorp D, Ho JQK, Dart GW, Horvath N, Davy MLJ, Olweny CLM, Abdi E, Juttner CA: Comparison of haematological recovery times and supportive care requirements of autologous recovery phase peripheral blood stem cell transplants, autologous bone marrow transplants and allogeneic bone marrow transplants. Bone Marrow Transplant 9:277, 1992
20. + cells into the myeloid lineage. Blood 80:1405, 1992
21. + hematopoietic stem cells. Blood 83:3758, 1994
22. Zijlmans JMJM, Kleiverda K, Heemskerk DPM, Kluin PM, Visser JWM, Willemze R, Fibbe WE: No role for committed progenitor cells in engraftment following transplantation of murine cytokine-mobilized blood cells. Blood 86: 112a, 1995 (abstr, suppl 1)
23. Williams DA: Ex vivo expansion of hematopoietic stem and progenitor cells - Robbing Peter to pay Paul? Blood 81:3169, 1993
24. Muench MO, Firpo MT, Moore MAS: Bone marrow transplantation with interleukin-1 plus kit-ligand ex vivo expanded bone marrow accelerates hematopoietic reconstitution in mice without the loss of stem cell lineage and proliferative potential. Blood 81:3463, 1993
25. Peters SO, Kittler ELW, Ramshaw HS, Quesenberry PJ: Ex vivo expansion of murine marrow cells with interleukin-3 (IL-3), IL-6, IL-11, and stem cell factor leads to impaired engraftment in irradiated hosts. Blood 87:30, 1996
26. Knobel KM, McNally MA, Berson AE, Rood D, Chen K, Kilinski L, Tran K, OkarmaTB, Lebkowski JS: Long-term reconstitution of mice after ex vivo expansion of bone marrow cells: Differential activity of cultured bone marrow and enriched stem cell populations. Exp Hematol 22:1227, 1994
27. Traycoff CM, Cornetta K, Yoder MC, Davidson A, Srour EF: Ex vivo expansion of murine hematopoietic progenitor cells generates classes of expanded cells possessing different levels of bone marrow repopulating potential. Exp Hematol 24:299, 1996
28. Brandt J, Srour EF, Van Besien K, Briddell RA, Hoffman R: Cytokine-dependent long-term culture of highly enriched precursors of hematopoietic progenitor cells from human bone marrow. J Clin Invest 86:932, 1990
29. Srour EF, Brandt JE, Briddell RA, Grigsby S, Leemhuis T, Hoffman R: Long-term generation and expansion of human primitive hematopoietic progenitor cells in vitro. Blood 81:661, 1993
30. +-selected human peripheral blood progenitor cells. Blood 84:2898, 1994
31. - cells is possible in a clinically suitable stroma conditioned medium culture supplemented with one or two cytokines. Blood 86:294a, 1995 (abstr, suppl 1)
32. Petzer AL, Hogge DE, Lansdorp PM, Reid DS, Eaves CJ: Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium. Proc Natl Acad Sci USA 93:1470, 1996
33. Brugger W, Heimfeld S, Berenson RJ, Mertelsmann R, Kanz L: Reconstitution of hematopoiesis after high-dose chemotherapy by autologous progenitor cells generated ex vivo. N Engl J Med 333:283, 1995
34. Champlin R, Mehra R, Gajewski J, Khouri I, Geisler D, Davis M, Oba K, Thomas M, Armstrong RD, Douville J, Weber S, Silver S, Muller T, Deisseroth A: Ex vivo expanded progenitor cell transplantation in patients with breast cancer. Blood 86:295a, 1995 (abstr, suppl 1)
35. + cells in autologous stem cell transplantation for breast cancer. Blood 87:1687, 1996
36. Holyoake TL, Alcorn MJ, Richmond L, Pearson C, Farrell E. Kyle B, Dunlop DJ. Fitzsimons E, Steward WP, Pragnell IB, Franklin IM: A phase I study to evaluate the safety of re-infusing CD34 cells expanded ex vivo as part or all of a PBPC transplant procedure. Blood 86:294a, 1995 (abstr, suppl 1)
37. Szilvassy SJ, Weller KP, Lin W, Sharma AK, Ho ASY, Tsukamoto A, Hoffman R, Leiby K, Gearing DP: Leukemia inhibitory factor upregulates cytokine expression by a murine stromal cell line enabling maintenance of highly enriched competitive repopulating stem cells. Blood 87:4618, 1996
38. Spangrude GJ, Heimfeld S, Weissman IL: Purification and characterization of mouse hematopoietic stem cells. Science 241:58, 1988
39. Till JE, McCulloch EA: A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res 14:213, 1961
40. Szilvassy SJ, Humphries RK, Lansdorp PM, Eaves AC, Eaves CJ: Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy. Proc Natl Acad Sci USA 87:8736, 1990
41. Szilvassy SJ, Lansdorp PM, Humphries RK, Eaves AC, Eaves CJ: Isolation in a single step of a highly enriched murine hematopoietic stem cell population with competitive long-term repopulating ability. Blood 74:930, 1989
42. Harrison DE, Astle CM: Loss of stem cell repopulating ability upon transplantation: Effects of donor age, cell number, and transplantation procedure. J Exp Med 156:1767, 1982
43. Szilvassy SJ, Cory S: Phenotypic and functional characterization of competitive long-term repopulating hematopoietic stem cells enriched from 5-fluorouracil-treated murine marrow. Blood 81:2310, 1993
44. Taswell C: Limiting dilution assays for the determination of immunocompetent cell frequencies: I. Data analysis. J Immunol 126:1614, 1981
45. + cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow. J Exp Med 175:175, 1992
46. Okamoto T, Kanamaru A, Hara H, Nagai K: Changes in expression of major histocompatibility complex (MHC) class-I antigen on hematopoietic progenitors during murine development. Exp Hematol 15:190, 1987
47. Eaves AC, Bruce WR: Endotoxin-induced sensitivity of hematopoietic stem cells to chemotherapeutic agents. Ser Haemat 2:64, 1972
48. De Vries P, Brasel KA, Eisenman JR, Alpert AR, Williams DE: The effect of recombinant mast cell growth factor on purified murine hematopoietic stem cells. J Exp Med 173:1205, 1991
49. Migliaccio G, Migliaccio AR, Valinsky J, Langley K, Zsebo K, Visser JWM, Adamson JW: Stem cell factor induces proliferation and differentiation of highly enriched murine hematopoietic cells. Proc Natl Acad Sci USA 88:7420, 1991
50. Li CL, Johnson GR: Stem cell factor enhances the survival but not the self-renewal of murine hematopoietic long-term repopulating cells. Blood 84:408, 1994
51. Heimfeld S, Hudak S, Weissman I, Rennick D: The in vitro response of phenotypically defined stem cells and myeloerythroid progenitors to single or multiple growth factors. Proc Natl Acad Sci USA 88:9902, 1991
52. + hemopoietic stem cells. J Exp Med 175:1443, 1992
53. Jones RJ, Celano P, Sharkis SJ, Sensenbrenner LL: Two phases of engraftment established by serial bone marrow transplantation in mice. Blood 73:397, 1989
54. Jones RJ, Wagner JE, Celano P, Zicha MS, Sharkis SJ: Separation of pluripotent haematopoietic stem cells from spleen colony-forming cells. Nature 347:188, 1990
55. Spangrude GJ, Johnson GR: Resting and activated subsets of mouse multipotent hematopoietic stem cells. Proc Natl Acad Sci USA 87:7433, 1990
56. Phillips RL, Reinhart AJ, Van Zant G: Genetic control of murine hematopoietic stem cell pool sizes and cycling kinetics. Proc Natl Acad SCi USA 89:11607, 1992
57. Dunlop DJ, Wright EG, Lorimore S, Graham GJ, Holyoake T, Kerr DJ, Wolpe SD, Pragnell IB: Demonstration of stem cell inhibition and myeloprotective effects of SCI/rhMIP-1α in vivo. Blood 79:2221, 1992
58. Quesniaux VFJ, Graham GJ, Pragnell I, Donaldson D, Wolpe SD, Iscove NN, Fagg B: Use of 5-fluorouracil to analyze the effect of macrophage inflammatory protein-1α on long-term reconstituting stem cells in vivo. Blood 81:1497, 1993
59. - Peripheral blood stem cells (PBSC) effect timely trilineage engraftment in multiple myeloma (MM). Blood 86:293a, 1995 (abstr, suppl 1)