Synthesis and physicochemical analysis of interpenetrating networks containing modified gelatin and poly(ethylene glycol) diacrylate

Journal of Biomedical Materials Research - Part A

Volumn 67, Issue 1, 2003, Pages 224-234

  Burmania, Jeanine A ^a,b   Martinez Diaz, Gabriel J ^a   Kao, Weiyuan John ^a,b  

^a University of Wisconsin Madison   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Biomaterials; Drug delivery; Ethylenediaminetetraacetic dianhydride; Swelling degradation; Tensile properties

Indexed keywords

DEGRADATION; ELASTICITY; HYDROGELS; HYDROPHILICITY; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; SWELLING; SYNTHESIS (CHEMICAL); TENSILE PROPERTIES;

PHYSIOCHEMICAL PROPERTIES;

BIOMATERIALS;

CHLORHEXIDINE GLUCONATE; EDETIC ACID; GELATIN; MACROGOL DERIVATIVE; POLY(ETHYLENE GLYCOL) DIACRYLATE; UNCLASSIFIED DRUG;

ARTICLE; DEGRADATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG RELEASE; ELASTICITY; HYDROPHILICITY; MELTING POINT; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; SYNTHESIS; TENSILE STRENGTH;

EID: 0345168971     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbm.a.10106     Document Type: Article

References (24)

1. Elisseeff J, Anseth K, Sims D, McIntosh W, Randolph M, Yaremchuk M, Langer R. Transdermal photopolymerization of poly(ethylene oxide)-based injectable hydrogels for tissue-engineered cartilage. Plast Reconstr Surg 1999;104(4):1014-1022.
2. Hasirci V, Lewandrowski KU, Bondre SP, Gresser JD, Trantolo DJ, Wise DL. High strength bioresorbable bone plates: Preparation, mechanical properties and in vitro analysis. Biomed Mater Eng 2000:10(1);19-29.
3. Song L, Liu T, Liang D, Fang D, Chu B. Separation of double-stranded DNA fragments by capillary electrophoresis in interpenetrating networks of polyacrylamide and polyvinylpyrrolidone. Electrophoresis 2001;22(17):3688-3698.
4. Kosmala JD, Henthorn DB, Brannon-Peppas L. Preparation of interpenetrating networks of gelatin and dextran as degradable biomaterials. Biomaterials 2000;21(20):2019-2023.
5. Elisseeff J, McIntosh W, Anseth K, Riley S, Ragan P, Langer R. Photoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks. J Biomed Mater Res 2000;51:164-171.
6. Okino H, Nakayama Y, Tanaka M, Matsuda T. In situ hydrogelation of photocurable gelatin and drug release. J Biomed Mater Res 2002;59:233-245.
7. Bozzy J, David A, Denes M, Rusznak I. Production of granules with controlled drug release rate. Pharmazie 1979;34:172-174.
8. Yamamoto M, Tabata Y, Hong L, Miyamoto S, Hashimoto N, Ikada Y. Bone regeneration by transforming growth factor beta1 released from a biodegradable hydrogel. J Control Release 2000;64:133-142.
9. McDonald JA, Kelley DG, Broekelmann TJ. Role of fibronectin in collagen deposition: Fab' to the gelatin-binding domain of fibronectin inhibits both fibronectin and collagen organization in fibroblast extracellular matrix. J Cell Biol 1982;92:485-492.
10. Thomson RC, Yaszemski MJ, Powers JM, Mikos AG. Fabrication of biodegradable polymer scaffolds to engineering trabecular bone. J Biomater Sci Polym Ed 1995;7:23-38.
11. Choi YS, Hong SR, Lee YM, Song KW, Park MH, Nam YS. Studies on gelatin-containing artificial skin. II. Preparation and characterization of cross-linked gelatin-hyaluronate sponge. J Biomed Mater Res 1999;48:631-639.
12. Budavari S, editor. Merck index. 12th ed., no. 4388. Whitehouse Station, NJ: Merck Research Laboratories Division of Merck & Co.; 1996. p 742.
13. Hwang DC, Damodaran S. Chemical modification strategies for synthesis of protein-based hydrogel. J Agric Food Chem 1996;44:751-758.
14. Zhang M, Li XH, Gong YD, Zhao NM, Zhang XF. Properties and biocompatibility of chitosan films modified by blending with PEG. Biomaterials 2002;23:2641-2648.
15. Harris JM, Zalipsky S, editors. Poly(ethylene glycol) chemistry and biological applications, ACS symposium series 680. Danvers, MA: American Chemical Society; 1997.
16. Harris JM, Struck EC, Case MG, Paley MS. Synthesis and characterization of poly(ethylene glycol) derivatives. J Polym Sci Polym Chem Ed 1984;22:341-352.
17. Hall J, Trinder N, Givens DI. Observation on the use of 2,4,6-trinitrobenzenesulphonic acid for the determination of available lysine in animal protein concentrates. Analyst 1973;98:673-686.
18. Offner CM, Bubnis WA. Chemical and swelling evaluations of amino group crosslinking in gelatin and modified gelatin matrices. Pharm Res 1996;13:1821-1827.
19. Einerson NJ, Stevens KR, Kao WJ. Synthesis and physicochemical analysis of gelatin-based hydrogels for drug carrier matrices. Biomaterials 2003;24:509-523.
20. Hamilton WC. A technique for the characterization of hydrophilic solid surfaces. J Colloid Interface Sci 1972;40:219-222.
21. Stevens KR, Einerson NJ, Burmania JA, Kao WJ. In vivo biocompatibility of gelatin-based hydrogels and interpenetrating networks. J Biomater Sci Polym Ed 2002;13(12):1353-1366.
22. Friedman M, Golomb G. New sustained release dosage form of chlorhexidine for dental use: Development and kinetics of release. J Periodontol Res 1982;17:323-328.
23. Van de Vaart FJ, Hulshoff A, Indemans AW. Analysis of creams: Quantitative determination of drugs in creams by UV spectrophotometry. Pharm Weekbl Sci 1980;2:179-185.
24. Zazhi ZX. Measurement of chlorhexidine content by ultraviolet spectrophotometry. Ch J Disinfect 1996;13:239-240.