Pilot study of concurrent cisplatin, 5-fluorouracil, and external beam radiotherapy prior to radical surgery +/- intraoperative electron beam radiotherapy in locally advanced cervical cancer

Gynecologic Oncology

Volumn 74, Issue 1, 1999, Pages 30-37

  Jurado, M ^a   Martinez Monge R ^b   Garcia Foncillas J ^b   Azinovic, I ^b   Aristu, J ^b   Lopez Garcia G ^a   Brugarolas, A ^b  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

^b UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Chemoradiation, preoperative; Intraoperative radiotherapy; Radical surgery

Indexed keywords

CISPLATIN; FLUOROURACIL;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW SUPPRESSION; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CLINICAL ARTICLE; ELECTRON BEAM; FEMALE; HUMAN; PRIORITY JOURNAL; RADIATION BEAM; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA;

EID: 0345161752     PISSN: 00908258     EISSN: None     Source Type: Journal    
DOI: 10.1006/gyno.1999.5424     Document Type: Article

References (38)

1. Montana G S, Fowler W C, Varia M A, Walton L A, Mack Y, Shemansky L. Carcinoma of the cervix stage III. Results of radiation therapy. Cancer. 57:1986;148-154.
2. Burghardt W, Baltzer J, Harjanto-Tulusan A, Haas J. Results of surgical treatment of 1028 cervical cancers studied with volumetry. Cancer. 70:1992;648-655.
3. Mendenhall W M, Thar T L, Bova F J. Prognostic and treatment factors affecting pelvic control of stage Ib and stage IIa-b carcinoma of the intact uterine cervix treated with radiation alone. Cancer. 53:1984;2649-2654.
4. Pérez C A, Grigsby P W, Nene S M, Camel H M, Galakatos A, Kao M S, Lockett M A. Effect of tumor size on the prognosis of carcinoma of the uterine cervix treated with irradiation alone. Cancer. 69:1992;605-911.
5. Kim R Y, Trotti A, Wu C J, Soong S J, Salter M M. Radiation alone in the treatment of cancer of the uterine cervix: analysis of pelvic failure and dose response relationship. Int J Radiat Oncol Biol Phys. 17:1989;973-978.
6. Coia L, Won M, Lanciano R, Marcial V A, Martz K, Hanks G. The patterns of care outcome study for cancer of the uterine cervix: results of the 2nd National Practice Survey. Cancer. 66:1990;2451-2456.
7. Fuller A F, Elliontt N, Kosloff C, Hoskins W J, Lewis J L Jr. Determinations of increased risk for recurrence in patients undergoing radical hysterectomy for stage Ib and IIa carcinoma of the cervix. Gynecol Oncol. 33:1989;34-39.
8. Grigsby P W. Primary radiotherapy for stage Ib or IIa cervical cancer. Monogr Natl Cancer Inst. 21:1996;61-64.
9. Petterson F. FIGO's annual report on the results of treatment in gynecological cancer. Int J Gynecol Obstet. 36:1991;1-315.
10. Pérez C A. Uterine Cervix. Perez C A, Brady L W. Principles and Practice of Radiation Oncology. 1988;1733-1834 Lippincott, Philadelphia.
11. Vokes E, Weichselbaum R. Concomitant chemoradiotherapy. Rationale and clinical experience in patients with solid tumors. J Clin Oncol. 8:1990;911-934.
12. Hill B T. Interaction between antitumor agents and radiation and expression of resistance. Cancer Treat Rev. 18:1991;149-190.
13. Heaton D, Yordan E, Reddy S, Bonomi P, Lee M S, Lincoln S, Graham J, Dolan T, Miller A, Phillips A, Kirschner C, Bergen S, Wilbanks G. Treatment of 129 patients with bulky squamous cell carcinoma of the cervix with simultaneous cisplatin, 5-fluorouracil and split-course hyperfractionated radiation therapy. Gynecol Oncol. 38:1990;323-327.
14. Thomas G, Dembo A, Fyles A, Gadalla T, Beale F, Bean H, Pringle J, Rawlings G, Bush R, Black B. Concurrent chemoradiation in advanced cervical cancer. Gynecol Oncol. 38:1990;446-451.
15. Malfetano J, Keys H, Kredeurser D, Cunningham-Kotlove D, Weiss L. Weekly cisplatin and radical radiation therapy for advanced recurrent and poor prognosis cervical carcinoma. Cancer. 71:1993;3703-3706.
16. Lin J C, Ho E SC, Jan J S, Yan C H, Linf F S. High complete response rate of concomitant chemoradiotherapy for locally advanced squamous cell carcinoma of the uterine cervix. Gynecol Oncol. 61:1996;101-108.
17. Jhon M, Flam M, Caplan R, Rotman M, Quivey J, Steinfeld A, Russell A. Final results of a phase II chemoradiation protocol for locally advanced cervical cancer: RTOG 85-15. Gynecol Oncol. 61:1996;221-226.
18. Fields A L, Anderson P S, Goldberg G L, Wadler S, Beitler J, Sood B, Runowicz C D. Mature results of a phase II trial of concurrent cisplatin/pelvic radiotherapy for local advanced squamous cell carcinoma of the cervix. Gynecol Oncol. 61:1996;416-422.
19. Bonomi P, Blessing J A, Stehman F B, Di Saia P J, Walton L, Major F J. Randomized trial of three cisplatin dose schedules in squamous cell carcinoma of the cervix. J Clin Oncol. 3:1985;1079-1085.
20. Rotmensh J, Snekjian K E, Ghodratollah J, Herbst A. Evaluation of bolus cis-platinum and continuous 5-fluorouracil infusion for metastatic and recurrent squamous cell carcinoma of the cervix. J Gynecol Oncol. 29:1998;76-81.
21. Resbeut M, Cowen D, Viens P, Norclerc M, Perez T, Gouvernet J, Delpero J R, Gamerre M, Boubli L, Hovenaeghel G. Concomitant chemoradiation prior to surgery in the treatment of advanced cervical carcinoma. Gynecol Oncol. 54:1994;68-75.
22. Parham G, Hicks M. Retroperitoneal lymphadenectomy followed by concomitant chemoradiation and tailored surgical debulking: a pilot multimodality protocol for advanced cervical and vaginal cancer. Proc Am Soc Clin Oncol. 14:1995;A809.
23. Pras E, Willemse P HB, Boonstra H, Hollema H, Heesters M A, Szabo B G, De Brujin H W, Aalders J G, De Vries E G. Concurrent chemo and radiotherapy in patients with locally advanced carcinoma of the cervix. Ann Oncol. 7:1996;511-516.
24. Calvo F A, Ortiz de Urbina D, Jurado M, De la Fuente F. Gynecologic Cancer. Calvo F A, Santos M, Brady L W. Intraoperative Radiotherapy. 1992;79-86 Springer-Verlag, Berlin, Heidelberg.
25. Yordan E L, Jurado M, Kiel K, Reddy S, Kramer T, Calvo F, Roseman D L, Graham J E, Wilbanks G. Intraoperative Radiation Therapy in the Treatment of Pelvic Malignancies: A Preliminary Report. Burghard, Monaghan J M. Operative Treatment of Cervical Cancer. Bailliere's Clinical Obstetrics and Gynecology. 1988;1023-1034 Bailliere, Tindall, London.
26. Cox D R. Regression models and life-tables. J R Stat Soc (B). 34:1972;187-220.
27. Kaplan E L, Meier P. Nonparametric estimation for incomplete observations. J Ann Stat Assoc. 4:1958;57-81.
28. Pérez C A, Perry W G, Chao K S, Mutch D, Lockett M A. Tumor size/extent and irradiation doses in outcome of carcinoma of uterine cervix. Int J Radiat Oncol Biol Phys. 39:1997;A72.
29. Hall E J. The Oxygen Effect and Reoxygenation. Hall E J. Radiobiology for the Radiobiologist. 1988;137-160 Lippincott, Philadelphia.
30. Rockwell S. Use of hypoxia-directed drugs in the therapy of solid tumors. Semin Oncol. 19:1992;29-40.
31. Todoroki T, Suit H D. Therapeutic advantage in preoperative single dose radiation combined with conservative and radical surgery in different size murine fibrosarcoma. J Surg Oncol. 29:1985;207-215.
32. Ramsay J, Suit H D, Sedlacek R. Experimental studies on the incidence of metastases after failure of radiation treatment and the effect of salvage surgery. Int J Radiat Oncol Biol Phys. 14:1988;1165-1168.
33. Paunier J O, Delclos L, Fletcher G H. Causes, time of death and sites of failure in squamous cell carcinoma of the uterine cervix. Radiology. 88:1967;555-562.
34. Pérez C A, Kuske R R, Camel H M, Galakatos A E, Hederman M A, Kao M S, Walz B J. Analysis of pelvic tumor control and impact on survival in carcinoma of the uterine cervix treated with radiation therapy alone. Int J Radiat Oncol Biol Phys. 14:1988;613-621.
35. Komaki R, Brickner T J, Hanlon A L, Owen J B, Hanks G E. Long-term results of treatment of cervical carcinoma in the United States in 1973, 1978 and 1983: Patterns of Care Study (PCS). Int J Radiat Oncol Biol Phys. 31:1995;973-982.
36. Mendenhall W M, Mc Carty P, Morgan L S, Chafe W E, Million R R. Stage IB or IIA-B carcinoma of the intact uterine cervix ≥ 6 cm in diameter: is adjuvant extrafascial hysterectomy beneficial. Int J Radiat Oncol Biol Phys. 21:1991;899-904.
37. Pérez C A, Camel H M, Kao M S, Hederman M A. Randomized study of preoperative radiation and surgery or irradiation alone in the treatment of stage IB and IIA carcinoma of the uterine cervix: final report. Gynecol Oncol. 27:1987;129-140.
38. Landoni F, Maneo A, Colombo A, Placa F, Milani R, Perego P, Favini G, Ferri L, Mangioni C. Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer. Lancet. 350:1997;535-540.