Efficiency of High-Flux Hemodialysis in the Treatment of Valproic Acid Intoxication

Journal of Toxicology - Clinical Toxicology

Volumn 41, Issue 6, 2003, Pages 873-876

  Kielstein, Jan T ^a   Woywodt, A ^a   Schumann, G ^a   Haller, H ^a   Fliser, D ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

GENIUS dialysis system; High flux hemodialysis; Valproic acid intoxication

Indexed keywords

VALPROIC ACID;

ADULT; ARTICLE; CASE REPORT; COST EFFECTIVENESS ANALYSIS; CRITICAL ILLNESS; DEVICE; DIALYSATE; DRUG INTOXICATION; EXTRACORPOREAL CIRCULATION; FATALITY; HEMODIALYSIS; HUMAN; INTENSIVE CARE UNIT; MALE; TREATMENT OUTCOME;

ADULT; ANTICONVULSANTS; HUMANS; MALE; RENAL DIALYSIS; SUICIDE, ATTEMPTED; THROMBOCYTOPENIA; VALPROIC ACID;

EID: 0345133463     PISSN: 07313810     EISSN: None     Source Type: Journal    
DOI: 10.1081/CLT-120025355     Document Type: Article

References (12)

1. Jones AL, Proudfoot AT. Features and management of poisoning with modern drugs used to treat epilepsy. QJM 1998; 91(5):325-332.
2. Morrow JI, Routledge, PA. Poisoning by anticonvulsants. Adverse Drug React Acute Poisoning Rev 1989; 8(2):97-109.
3. Sztajnkrycer MD. Valproic acid toxicity: overview and management. J Toxicol Clin Toxicol 2002; 40(6):789-801.
4. Fernandez MC, Walter FG, Kloster JC, Do SM, Brady LA, Villarin A, Ruffenach SJ, Prosnitz EH, Salmon JV. Hemodialysis and hemoperfusion for treatment of valproic acid and gabapentin poisoning. Vet Hum Toxicol 1996; 38(6):438-443.
5. Franssen EJ, van Essen GG, Portman AT, de Jong J, Go G, Stegeman CA, Uges DR. Valproic acid toxicokinetics: serial hemodialysis and hemoperfusion. Ther Drug Monit 1999; 21(3):289-292.
6. Roodhooft AM, Van Dam K, Haentjens D, Verpooten GA, Van Acker KJ. Acute sodium valproate intoxication: occurrence of renal failure and treatment with haemoperfusion-haemodialysis. Eur J Pediatr 1990; 149(5):363-364.
7. Tank JE, Palmer BF. Simultaneous "in series" hemodialysis and hemoperfusion in the management of valproic acid overdose. Am J Kidney Dis 1993; 22(2):341-344.
8. Dhamidharka VR, Fennell RS III, Richard GA. Extracorporeal removal of toxic valproic acid levels in children. Pediatr Nephrol 2002; 17(5):312-315.
9. Hicks LK, McFarlane PA. Valproic acid overdose and haemodialysis. Nephrol Dial Transplant 2001; 16(7):1483-1486.
10. Kane SL, Constantiner M, Staubus AE, Meinecke CD, Sedor JR. High-flux hemodialysis without hemoperfusion is effective in acute valproic acid overdose. Ann Pharmacother 2000; 34(10):1146-1151.
11. Zaccara G, Messori A, Moroni F. Clinical pharmacokinetics of valproic acid - 1988. Clin Pharmacokinet 1988; 15(6):367-389.
12. Mortensen PB, Hansen HE, Pedersen B, Hartmann-Andersen F, Husted SE. Acute valproate intoxication: biochemical investigations and hemodialysis treatment. Int J Clin Pharmacol Ther Toxicol 1983; 21(2):64-68.