Docosahexaenoic and arachidonic acid prevent a decrease in dopaminergic and serotoninergic neurotransmitters in frontal cortex caused by a linoleic and α-linolenic acid deficient diet in formula-fed piglets

Journal of Nutrition

Volumn 129, Issue 11, 1999, Pages 2088-2093

  De La Presa Owens, Sylvia ^a   Innis, Sheila M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Arachidonic acid; Docosahexaenoic acid; Dopaminergic; Essential fatty acids; Piglets; Serotoninergic

Indexed keywords

2',3' CYCLIC NUCLEOTIDE 3' PHOSPHODIESTERASE; 3,4 DIHYDROXYPHENYLACETIC ACID; 5 HYDROXYINDOLEACETIC ACID; ARACHIDONIC ACID; DNA; DOCOSAHEXAENOIC ACID; DOPAMINE; HOMOVANILLIC ACID; LINOLEIC ACID; LINOLENIC ACID; MONOAMINE; NEUROTRANSMITTER; NORADRENALIN; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLINOSITOL; SEROTONIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ESSENTIAL FATTY ACID DEFICIENCY; FRONTAL CORTEX; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NEWBORN; NONHUMAN; SWINE; THIN LAYER CHROMATOGRAPHY;

ANIMALIA; SUS SCROFA;

EID: 0345109281     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/129.11.2088     Document Type: Article

References (46)

1. Arbuckle, L. D. & Innis, S. M. (1992) Docosahexaenoic acid in developing brain and retina of piglets fed high or low alpha-linolenate formula with or without fish oil. Lipids 27: 89-93.
2. Arbuckle, L. D., MacKinnon, M. J. & Innis, S. M. (1994) Formula 18:2(n-6) and 18:3(n-3) content and ratio influence long-chain polyunsaturated fatty acids in developing piglet liver and central nervous tissue. J. Nutr. 124: 289-298.
3. Arbuckle, L. D., Rioux, F. M., MacKinnon, M. J., Hrboticky, N. & Innis S. M. (1991) Response of (n-3) and (n-6) fatty acids in piglet brain, liver and plasma to increasing, but low, fish oil supplementation of formula. J. Nutr. 121: 1536-1547.
4. Bourre, J. M., Francois, M., Youyou, A., Dumont, O., Piciotti, M., Pascal, G. & Durand, G. (1989) The effects of dietary α-linolenic acid on the composition of nerve membranes, enzyme activity, amplitude of electrophysiological parameter resistance to poisons and performance of learning tasks in rats. J. Nutr. 119: 1880-1892.
5. Brozosky, T. J., Brown, R. M., Rosvold, H. E. & Goldman, P. S. (1979) Cognitive deficient caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Science 205: 929-932.
6. Chen, P. S., Toribara, T. Y. & Warner, H. (1956) Microdetermination of phosphorus. Anal. Chem. 28: 1756-1758.
7. Clandinin, M. T., Wong, K. & Hacker, R. R. (1985) Synthesis of chain elongation-desaturation products of linoleic acid by liver and brain microsomes during development of the pig. Biochem. J. 226: 305-309.
8. Delion, S., Chalon, S., Guilloteau, D., Besnard, J. -C. & Dwand, G. (1996) Alpha-linolenic acid dietary deficiency alters age-related changes of dopaminergic and serotoninergic neurotransmission in the rat frontal cortex. J. Neurochem. 66: 1582-1591.
9. Delion, S., Chalon, S., Herault, J., Guilloteau, D., Besnard, J. C. & Durand, G. (1994) Chronic dietary α-linoleic acid deficiency alters dopaminergic and serotinergic neurotransmitters in rats. J. Nutr. 124: 2466-2476.
10. 14 C] linoleic acid into the adult rat brain. Biochem. Biophys. Acta 231: 8-14.
11. 14 C] linolenic acid into the adult rat brain. Biochem. Biophys. Acta 239: 162-167.
12. Edmond, J., Higa, T. A., Korsak, R. A., Bergner, E. A. & Lee, W. N. (1998) Fatty acid transport and utilization for the developing brain. J. Neurochem. 70: 1227-1234.
13. Enslen, M., Milan, H. & Malnoe, A. (1991) Effects of low intake of n-3 fatty acids during development on brain phospholipid fatty acid composition and exploratory behaviour in rats. Lipids 26: 203-208.
14. Folch, J., Lees, M. & Sloane-Stanley, G. H. A. (1957) A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226: 497-509.
15. Foote, K. D., Hrboticky, N. & Innis, S. M. (1990) Brian synaptosomal, liver, plasma and red blood cell lipids in piglets fed exclusively on a vegetable oil containing formula with and without fish oil supplements. Am. J. Clin. Nutr. 51: 1001-1009.
16. Frances, H., Monier, C., Clement, M., Lecorsier, A., Debray, M. & Bourre, J. M. (1996) Effect of dietary α-linolenic acid deficiency on habituation. Life Sci. 58: 1805-1816.
17. Hrboticky, N., MacKinnon, M. J., Puterman, M. L. & Innis, S. M. (1989) Effect of a linoleic acid infant formula feeding on brain synaptosomal lipid accretion and enzyme thermotropic behavior in the piglet. J. Lipid Res. 30: 1173-1184.
18. Innis S. M. (1992) The colostrum-deprived piglet as a model for study of infant lipid nutrition. J. Nutr. 123: 386-390.
19. Innis, S. M. & Dyer, R. (1997) Dietary triacylglycerols with palmitic acid (16:0) in the 2-position increase 16:0 in the 2-position of plasma and chylomicron triacylglycerols, but reduce phospholipid arachidonic acid and docosahexaenoic acids, and alter cholesteryl ester metabolism in formula-fed piglets. J. Nutr. 127: 1311-1319.
20. Innis, S. M., Dyer, R. & Nelson, C. M. (1994a) Evidence that palmitic acid is absorbed as sn-2 monoacylglycerol from human milk by breast-fed infants. Lipids 29: 541-545.
21. Innis, S. M., Nelson, C. M., Rioux, M. F. & King, D. J. (1994b) Development of visual acuity in relation to plasma and erythrocyte ω-6 and ω-3 fatty acids in healthy term gestation infants. Am. J. Clin. Nutr. 60: 347-52.
22. Lamptey, M. S. & Walker, B. L. (1976) A possible role for dietary linolenic acid in the development of the young rat. J. Nutr. 106: 86-93.
23. Lin D. S., Connor, W. E., Anderson, G. J. & Neuringer, M. (1990) Effects of dietary n-3 fatty acids on the phospholipid molecular species of monkey brain. J. Neurochem. 55: 1200-1207.
24. Lowry, O. H., Rosebrough, N. S., Farr, A. L. & Randall, R. J. (193) (1951) Protein measurement with folin reagents. J. Biol. Chem. 265-275.
25. Makrides, M., Neumann, M. A., Simmer, K. & Gibson, R. A. (1995) Erythrocyte fatty acids of term infants fed either breast milk, standard formula, or formula supplemented with long-chain polyunsaturates. Lipids. 30: 941-948.
26. McEntee, W. J. & Cook, T. J. (1991) Serotonin, memory and the aging brain. Psychopharmacology 103: 143-149.
27. Moore, S. A., Yoder, E. & Spector, A. A. (1990) Role of the blood-brain barrier in the formation of long-chain ω-3 and ω-6 fatty acids from essential fatty acid precursors. J. Neurochem. 55: 391-402.
28. Moore, S. A., Yoder, E., Murphy, S., Dutton, G. R. & Spector, A. A. (1991) Astrocytes, not neurons, produce docosahexaenoic acid (22:6ω-3) and ara-chidonic acid (20:4ω-6). J. Neurochem. 56: 518-524.
29. Norton, W. T. & Cammer, W. (1985) Isolation and characterization of myelin. In: Myelin (Morrell, P., ed.), pp. 148-153. Plenum Press, New York, NY.
30. 1 - phosphahydrolase. Anal. Biochem. 56: 275-282.
31. Putnam, J. C., Carlson, S. E., Devoe, P. W. & Barness, J. S. (1982) The effects of variations in dietary fatty acids on the fatty acid composition of erythrocyte phosphatidylcholine and phosphatidylethanolamine in human infants. Am. J. Clin. Nutr. 36: 106-114.
32. Reisbick, S., Neuringer, M., Hasain, R. & Connor, W. E. (1990) Polydipsia in Rhesus monkeys deficient in omega-3 fatty acids. Physiol. Behav. 47: 315-323.
33. Sastry P. S. (1985) Lipids of nervous tissue: composition and metabolism. Prog. Lipid Res. 24: 69-176.
34. Simon, H., Scatton, B. & de Moal, M. (1980) Dopaminergic A 10 neurons are involved in cognitive functions. Nature 286: 150-151.
35. Sprecher, H., Luthria, D. L., Mohammed, B. S. & Baykousheva, S. P. (1995) Reevaluation of the pathways for the biosynthesis of polyunsaturated fatty acids. J. Lipid Res. 36: 2471-2477.
36. Utsunomiya, A., Owanda, Y., Yoshimoto, T. & Kondo, H. (1997) Localization of mRNA for fatty acid transport protein in developing and mature brain of rats. Brain Res. Mol. Brain Res. 46: 217-222.
37. Wainwright, P. E. & Ward, G. R. (1997) Early nutrition and behaviour: A conceptual framework for critical analysis of research. In: Developing Brain and Behaviour: The Role of Lipids in Infant Formula. (Dobbing, J., ed.) pp. 388-425. Academic Press. San Diego, CA.
38. Wainwright, P. E., Bulman-Fleming, M. B., Lévesque, S., Mutsaer, L. & McCutcheon, D. (1999) A saturated-fat diet during development alters dendritic growth in mouse brain. Nutritional Neurosci. 1: 49-58.
39. Wainwright, P. E., Xing, X. -C., Mutsaers, L., McCutcheon, D. & Kyle, D. (1997) Arachidonic acid offsets the effects on mouse brain and behaviour of a diet with a low (n-6)-(n-3) ratio and very high levels of docosahexaenoic acid. J. Nutr. 127: 184-193.
40. Weisinger, H. S., Vingrys, A. J. & Sinclair, A. J. (1996) The effect of docosahexaenoic acid on the electroretinogram of the guinea pig. Lipids 31: 65-70.
41. Xu, L. Z., Sanchez, R., Sali, A. & Heintz, N. (1996) Ligand specificity of brain lipid-binding protein. J. Biol. Chem. 271: 24711-719.
42. Yeh, Y. Y., Yeh, S. M. & Lien, E. L. (1998) Modification of milk formula to enhance accretion of long-chain n-6 and n-3 polyunsaturated fatty acids in artificially reared infant rats. Lipids 33: 513-20.
43. Yamamoto, N., Hashimoto, A., Takemoto, Y., Okuyama, H., Nomura, M., Kitajima, R., Togashi, T. & Tamai, Y. (1988) Effect of dietary α-linolenate/linoleate balance on lipid composition and learning hability in rats. II. Discrimination process, extinction process, and glycolipid compositon. J. Lipid Res. 29: 1013-1021.
44. Yoshida, S., Yashuda, A., Kawazato, H., Sakai, K., Shimada, T., Takeshita, M., Yuasa, S., Kobayashi, T., Watanabe, S. & Okuyama, H. (1997) Synaptic vesicle ultrastructural changes in the rat hippocampus induced by a combination of α-linoleate deficiency and a learning task. J. Neurochem. 68: 1261-1268.
45. Youyou, A., Durand, G., Pascal, G., Piciotti, M., Dumont, O. & Bourre, J. M. (1986) Recovery of altered fatty acid composition induced by a diet devoid of n-3 fatty acids in myelin, synaptosomes, mitochondria, and microsomes of developing rat brain. J. Neurochem. 46: 224-228.
46. Zimmer, L., Hembert, S., Dward, G., Breton, P., Guilloteau, D., Besnard, J. -C. & Chalm, S. (1998) Chronic n-3 polyunsaturated fatly acid diet-deficiency acts on dopamine metabolism in the rat frontal cortex: a microdialysis study. Neurosci. Lett. 240: 177-181.