Influence of cytarabine and cyclophosphamide on the disposition kinetics of cyclosporin A after bone marrow transplantation

Transplant International

Volumn 16, Issue 11, 2003, Pages 788-793

  Shimada, Tsutomu ^a   Aoki, Yuki ^a   Yokogawa, Koichi ^a   Nomura, Masaaki ^a   Ishizaki, Junko ^a   Nishigami, Jun ^a   Miyamoto, Ken Ichi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

Cyclophosphamide; Cyclosporin A; CYP3A2; Disposition kinetics; Drug interaction; P glycoprotein

Indexed keywords

CYCLOPHOSPHAMIDE; CYCLOSPORIN A; CYTARABINE; CYTOCHROME P450 3A2; GLYCOPROTEIN P; METHYLPREDNISOLONE; PROTEIN MDR1A; PROTEIN MDR1B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BONE MARROW TRANSPLANTATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; GRAFT VERSUS HOST REACTION; HUMAN; IMMUNOBLOTTING; LIVER MICROSOME; MEAN RESIDENCE TIME; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WHOLE BODY RADIATION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; ATP-BINDING CASSETTE TRANSPORTERS; BLOTTING, WESTERN; BONE MARROW TRANSPLANTATION; CYCLOPHOSPHAMIDE; CYCLOSPORINE; CYTARABINE; IMMUNOSUPPRESSIVE AGENTS; LIVER; MALE; MEMBRANE PROTEINS; OSMOLAR CONCENTRATION; P-GLYCOPROTEIN; P-GLYCOPROTEINS; POSTOPERATIVE PERIOD; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0345098545     PISSN: 09340874     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00147-003-0618-y     Document Type: Article

References (16)

1. Yokogawa K, Shimada T, Higashi Y, Itoh Y, Masue T, Ishizaki J, Asahi M, Miyamoto K (2002) Modulation of mdrla and CYP3A gene expression in the intestine and liver as possible cause of changes in the cyclosporin A disposition kinetics by dexamethasone. Biochem Pharmacol 63: 777-783
2. Shimada T, Terada I, Yokogawa K, Kaneko H, Nomura M, Kaji K, Kaneko S, Kobayashi K, Miyamoto K (2002) Lowered blood concentration of tacrolimus and its recovery with changes in expression of CYP3A and P-glycoprotein after high-dose steroid therapy. Transplantation 74: 1419-1424
3. David-Neto E, Ballarati CA, Freitas OJ, Lemos FC, Nahas WC, Arap S, Kalil J (2000) Comparison of the fluorescent polarization (TDx) and the enzymatic competitive (EMT 2000) immune assays for the measurement of cyclosporin A blood concentration. Rev Hosp Clin Fac Med Sao Paulo 55: 207-212
4. Chin JE, Soffir R, Noonan KE, Choi K, Roninson IB (1989) Structure and expression of the human MDR (P-glycoprotein) gene family. Mol Cell Biol 9: 3808-3820
5. Oinonen T, Lindros KO (1995) Hormonal regulation of the zonated expression of cytochrome P-450 3A in rat liver. Biochem J 309: 55-61
6. Waki Y, Miyamoto K, Kasugai S, Ohya K (1995) Osteoporosis-like changes in Walker carcinoma 256-bearing rats, not accompanied with hypercalcemia or parathyroid hormone-related protein production. Jpn J Cancer Res 86: 470-476
7. Kamataki T, Kitagawa H (1974) Effects of lyophilization and storage of rat liver microsomes on activity of aniline hydroxylase, contents of cytochrome b5 and cytochrome P-450 and aniline-induced P-450 difference spectrum. Jpn J Pharmacol 24: 195-203
8. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275
9. Laemmli UK (1970) Cleavage of structure proteins during the assembly of the head of bacteriophage T4. Nature (Lond) 227: 680-685
10. Guengerich FP, Wang P, Davidson NK (1982) Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Biochemistry 21: 1698-1706
11. Yamaoka K, Nakagawa T, Uno T (1978) Statistical moments in pharmacokinetics. J Pharmacokinet Biopharm 6: 547-558
12. Dumont RJ, Ensom MHH (2000) Methods for clinical monitoring of cyclosporin in transplant patients. Clin Pharmacokinet 38: 427-447
13. Saeki T, Ueda K, Tanigawara Y, Hori R, Komano T (1993) Human P-glycoprotein transports cyclosporin A and FK506. J Biol Chem 268: 6077-6080
14. Lampen A, Christians U, Guengerich FP, Watkins PB, Kolars JC, Bader A, Gonschior AK, Dralle H, Hackbarth I, Sewing KF (1995) Metabolism of the immunosuppressant tacrolimus in the small intestine: Cytochrome P450, drug interactions, and interindividual variability. Drug Metab Dispos 23: 1315-1324
15. Tanaka K, Hirai M, Tanigawara Y, Yasuhara M, Hori R, Ueada K, Inui K (1996) Effect of cyclosporin acyclosporin a Analogues and FK506 on transcellular transport of daunorubicin and vinblastine via P-glycoprotein. Pharm Res 13: 1073-1077
16. Bader A, Knop E, Boker KH, Crome O, Fruhauf N, Gonschior AK, Christians U, Esselmann H, Pichlmayr R, Sewing KF (1996) Tacrolimus (FK506) biotransformation in primary rat hepatocytes depends on extracellular matrix geometry. Naunyn Schmiedebergs Arch Pharmacol 353: 461-473