Very slow autoxidation of low-density lipoprotein spares α-tocopherol

Chemistry and Physics of Lipids

Volumn 94, Issue 1, 1998, Pages 63-70

  Herak, Janko N ^a   Krilov, Dubravka ^b   Stojanović, Nataša ^a   Marincel, Jasna ^c  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b UNIVERSITY OF ZAGREB   (Croatia)

^c Pharmaceutical   (Croatia)

Author keywords

tocopherol; EPR; Low density lipoprotein; Oxidation; Oxygen consumption

Indexed keywords

ALPHA TOCOPHEROL; EDETIC ACID; FREE RADICAL; LIPID HYDROPEROXIDE; LOW DENSITY LIPOPROTEIN; OXYGEN;

ARTICLE; AUTOOXIDATION; HUMAN; HUMAN EXPERIMENT; LIPID PEROXIDATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; TEMPERATURE;

HUMANS; LIPOPROTEINS, LDL; MALE; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; PEROXIDES; TEMPERATURE; VITAMIN E;

EID: 0345020385     PISSN: 00093084     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-3084(98)00044-9     Document Type: Article

References (27)

1. Berliner J.A., Heinecke J.W. The role of oxidized lipoproteins in atherogenesis. Free Radical Biol. Med. 20:1996;707-727.
2. Bowry V.W., Stocker R. Tocopherol-mediated peroxidation. The prooxidant effect of vitamin E on the radical-initiated oxidation of human low-density lipoprotein. J. Am. Chem. Soc. 115:1993;6029-6044.
3. Bowry V.W., Mohr D., Cleary J., Stocker R. Prevention of tocopherol-mediated peroxidation of ubiquinol-10-free human low density lipoprotein. J. Biol. Chem. 270:1995;5756-5763.
4. Buettner G.R., Jurkiewicz B.A. Catalytic metals, ascorbate and free radicals: combination to avoid. Radiat. Res. 145:1996;532-541.
5. Dunford H.B. Free radicals in iron-containing systems. Free Radical Biol. Med. 3:1987;405-421.
6. El-Saadani M., Esterbauer H., El-Sayed M., Goher M., Nassar A.Y., Jürgens G. A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent. J. Lipid Res. 30:1989;627-630.
7. Esterbauer H., Gebicki J., Puhl H., Jürgens G. The role of lipid peroxidation and antioxidant in oxidative modification of LDL. Free Radical Biol. Med. 13:1992;341-390.
8. Esterbauer H., Jürgens G. Mechanistic and genetic aspects of susceptibility of LDL to oxidation. Curr. Opin. Lipidol. 4:1993;114-124.
9. Esterbauer H., Schmidt R., Hayn M. Relation among oxidation of low-density lipoprotein, antioxidant protection and atherosclerosis. Adv. Pharmacol. 38:1997;425-455.
10. Gebicki J.M., Collins J., Baoutina A., Phair P. The limitations of an iodometric aerobic assay for peroxydes. Anal. Biochem. 240:1996;235-241.
11. Ingold K.U., Bowry V.W., Stocker R., Walling C. Autoxidation of lipids and antioxidation by α-tocopherol and ubiquinol in homogenous solution and in aqueous dispersions of lipids: unrecognized consequences of lipid particle size as exemplified by oxidation of human low density lipoprotein. Proc. Natl. Acad. Sci. USA. 90:1993;45-49.
12. Kleinveld H.A., Hak-Lemmers H.L.M., Stalenhoef A.F.H. Improved measurement of low-density lipoprotein susceptibility to copper-induced oxidation: application of a short procedure for isolating low-density lipoprotein. Clin. Chem. 38:1992;2066-2072.
13. Kontush A., Meyer S., Finkh B., Kohlschrütter A., Beisiegel U. α-Tocopherol as a reductant for Cu(II) in human lipoproteins. J. Biol. Chem. 271:1996;11106-11112.
14. Krilov D., Herak-Kramberger C.M., Ukrainczyk T., Herak J.N. Formation of free radicals in oxidation of human low-density lipoprotein. An EPR spin trapping study. Croat. Chem. Acta. 68:1995;409-415.
15. 2 uptake by Chinese hamster ovary cells during the cell cycle. Proc. Natl. Acad. Sci. USA. 79:1982;1166-1170.
16. Lee D.M. Isolation and characterization of LDL. Day C.E., Levy R.S. Low Density Lipoproteins. 1976;3-47 Plenum, New York.
17. Lidl, P.R. (Ed.), 1996. Handbook of Chemistry and Physics, 77th ed. CRC Press, Boca Raton, FL, pp. 4-6.
18. Neuzil J., Thomas S.R., Stocker R. Requirement for, promotion, or inhibition by alpha tocopherol of radical-induced initiation of plasma lipoprotein lipid peroxidation. Free Radical Biol. Med. 22:1997;57-71.
19. Noguchi N., Gotoh N., Niki E. Dynamics of the oxidation of low density lipoprotein induced by free radicals. Biochim. Biophys. Acta. 1168:1993;348-357.
20. Rankin S.M., Partasarathy S., Steinberg D. Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages. J. Lipid Res. 32:1991;448-456.
21. Steinberg D., Parthasarathy S., Carew T.E., Khoo J.C., Witztum J.L. Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. New Engl. J. Med. 320:1989;915-924.
22. Stocker R., Bowry V.W., Frei B. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does α-tocopherol. Proc. Natl. Acad. Sci. USA. 88:1991;1646-1650.
23. Subczynski W.K., Hyde J.S. Diffusion of oxygen in water and hydrocarbons using an electron spin resonance spin-label technique. Biophys. J. 45:1984;743-748.
24. Tertov V.V., Dvoryantsev S.N., Orekhov A.N. Apolipoprotein B-bound lipids as a marker for evaluation of low density lipoprotein oxidation in vivo. Biochem. Biophys. Res. Commun. 214:1995;608-613.
25. Tribble D.L., Van den Berg J.J.M., Motchnik P.A., Ames B.N., Lewis D.M., Chait A., Krauss R. Oxidative susceptibility of low density lipoprotein subfractions is related to their ubiquinol-10 and alpha-tocopherol content. Proc. Natl. Acad. Sci. USA. 91:1994;1183-1187.
26. Wieland E., Parthasarathy S., Steinberg D. Peroxidase-dependent metal-independent oxidation of low-density lipoprotein in vitro-A model for in vivo oxidation. Proc. Natl. Acad. Sci. USA. 90:1993;5929-5933.
27. Yoshida Y., Tsuchiya J., Niki E. Interaction of alpha-tocopherol with copper and its effect on lipid peroxidation. Biochim. Biophys. Acta. 1200:1994;85-92.