Introduction to the Aging of Primary Lymphoid Organs: Cellular or Homeostatic Failure?

Microscopy Research and Technique

Volumn 62, Issue 6, 2003, Pages 461-463

  Garcia Suarez O ^a,b   Vega, J A ^b,c  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF OVIEDO   (Spain)

^c Depto de Morfol y Biologia Celular

Author keywords

[No Author keywords available]

Indexed keywords

CELLULARS; LYMPHOID ORGANS;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AGING; BONE MARROW; CELL FUNCTION; CELL MATURATION; EDITORIAL; HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; LYMPHOID ORGAN; MACROPHAGE; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; STROMA; T LYMPHOCYTE; THYMUS ATROPHY; THYMUS FUNCTION; THYMUS TRANSPLANTATION;

EID: 0345016296     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jemt.10407     Document Type: Editorial

References (30)

1. Anderson G, Moore N, Owen JJT, Jenkinson EJ. 1996. Cellular interactions in thymocytes development. Annu Rev Immunol 14:73-99.
2. Appay V, Rowland-Jones SL. 2002. Premature ageing of the immune system: the cause of AIDS? Trends Immunol 23:580-585.
3. Aspinall R. 2000. Longevity and the immune response. Biogerontology 1:273-278.
4. Aspinal R, Andrew D. 2000a. Thymic atrophy in the mouse is a soluble problem of the thymic environment. Vaccine 18:1629-1637.
5. Aspinal R, Andrew D. 2000b. Thymic involution in aging. J Clin Immunol 20:250-256.
6. Aspinal R, Andrew D. 2001. Gender-related differences in the rates of age associated thymic atrophy. Dev Immunol 8:95-106.
7. Beverley PC, Grubeck-Loebenstein B. 2000. Is immune senescence reversible? Vaccine 18:1721-1724.
8. Berthiaume F, Aparicio CL, Eungdamrong J, Yarmush ML. 1999. Age- and disease-related decline in immune function: an opportunity for "thymus-boosting" therapies. Tissue Eng 5:499-514.
9. Berzins SP, Uldrich AP, Sutherland JS, Gill J, Limmer JFAP, Godfrey DI, Boyd RL. 2002. Thymic regeneration: teaching and old immune system new tricks. Trends Mol Med 8:469-476.
10. Bodey B, Bodey B Jr, Siegel SE, Kaiser HE. 1997. Involution of the mammalian thymus, one of the leading regulators of ageing. In Vivo 11:421-440.
11. Dardanne M. 1999. Role of thymic peptides as transmitters between the neuroendocrine and immune systems. Ann Med 31(Suppl 2): 34-39.
12. Dardanne M, Savino W. 1994. Control of thymus physiology by peptidic hormones and neuropeptides. Immunol Today 15:518-523.
13. Gavazzi G, Krause KH. 2002. Aging and infection. Lancet Infect Dis 2:659-666.
14. Glick B. 1991. Historical perspective: the bursa of Fabricius and its influence on B-cell development, past and present. Vet Immunol Immunopathol 30:3-12.
15. Globerson A, Effros RB. 2000. Ageing of lymphocytes and lymphocytes in the aged. Immunol Today 121:1-4.
16. Grubeck-Loebenstei B. 1997. Changes in the aging immune system. Biologicals 25:205-208.
17. Grubeck-Loebenstei B, Wick G. 2002. The aging of immune system. Adv Immunol 80:243-248.
18. Hirokawa K, Utsuyama M, Kobayashi S. 2001. Hypothalamic control of thymic function. Cell Mol Biol 47:97-102.
19. Hong R. 2001. The thymus. Finally getting some respect. Chest Surg Clin N Am 11:295-310.
20. Kelley KW, Davila DR, Brief S, Simon J, Arkins S. 1988. A pituitary-thymus connection during aging. Ann NY Acad Sci 521:88-98.
21. Kendall MD. 1991. Functional anatomy of the thymic microenvironment. J Anat 177:1-29.
22. Lloberas J, Celada A. 2002. Effect of aging on macrophage function. Exp Gerontol 37:1323-1329.
23. Malaguarnera L, Ferlito L, Imbesi RM, Gulizia GS, Di Mauro S, Maugeri D, Malaguarnera M, Messina A. 2001. Immunosenescence: a review. Arch Geronto Geriatr 32:1-14.
24. Moll UM. 1997. Functional histology of the neuroendocrine thymus. Microsc Res Tech 38:300-310.
25. Mountz JD, Van Zant GE, Zang HG, Grizzle WE, Ahmed R, Williams RW, Hsu HC. 2001. Genetic dissection of age-related changes of immune functions in mice. Scand J Immunol 54:10-20.
26. Ortman CL, Dittmar KA, White PL, Le PT. 2002. Molecular characterization of the mouse involuted thymus: aberrations in the expression of transcription regulators in thymocyte and epithelial compartments. Int Immunol 4:813-822.
27. Pido-Lopez J, Imami N, Aspinall R. 2001. Both age and gender affect thymic output: more recent thymic migrants in females than males as they age. Clin Exp Immunol 125:409-413.
28. Poulin JF, Viswanathan MN, Harris JM, Komanduri KV, Wieder E, Ringuette N, Jenkins M, McCune JM, Sekaly RP. 1999. Direct evidence for thymic function in adult humans. J Exp Med 16:479-486.
29. Straub RH, Cutolo M, Zietz B, Schölmerich J. 2001. The process of aging changes the interplay of the immune, endocrine and nervous systems. Mech Ageing Dev 122:1591-1611.
30. Uyemura K, Castle SC, Makinodan T. 2002. The frail elderly: role of dendritic cells in the susceptibility of infection. Mech Ageing Dev 123:955-962.