Prediction of Deleterious Functional Effects of Amino Acid Mutations Using a Library of Structure-Based Function Descriptors

Proteins: Structure, Function and Genetics

Volumn 53, Issue 4, 2003, Pages 806-816

  Herrgard, Sanna ^a,b   Cammer, Stephen A ^a,b,c   Hoffman, Brian T ^a   Knutson, Stacy ^a   Gallina, Marijo ^a   Speir, Jeffrey A ^a   Fetrow, Jacquelyn S ^a,d   Baxter, Susan M ^a  

^a Cengent Therapeutics Inc   (United States)

^b Ambit Biosciences   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d WAKE FOREST UNIVERSITY   (United States)

Author keywords

Fuzzy Functional Form ; Human genome; Protein structure; Single nucleotide polymorphism; SNP

Indexed keywords

AMINO ACID; ENZYME; PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; AUTOMATION; CALCULATION; CATALYSIS; DRUG METABOLISM; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; GENE LIBRARY; MUTATIONAL ANALYSIS; PREDICTION; PRIORITY JOURNAL; PROTEIN STRUCTURE; SINGLE NUCLEOTIDE POLYMORPHISM;

ALGORITHMS; AMINO ACIDS; ASPARTATE AMINOTRANSFERASES; BINDING SITES; COMPUTATIONAL BIOLOGY; ESCHERICHIA COLI PROTEINS; MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTEINS; REPRODUCIBILITY OF RESULTS;

EID: 0344980726     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.10458     Document Type: Article

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