Pseudolatex preparation using a novel emulsion-diffusion process involving direct displacement of partially water-miscible solvents by distillation

International Journal of Pharmaceutics

Volumn 188, Issue 2, 1999, Pages 155-164

  Quintanar Guerrero, D ^a,b,c   Allemann E ^b   Fessi, H ^c   Doelker, E ^b  

^a Campo 1   (Mexico)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c UNIVERSITÉ LYON 1   (France)

Author keywords

Cellulose acetate phthalate; Emulsion diffusion method; Eudragit E; Nanoparticles; Partially water miscible solvent; Pseudolatex

Indexed keywords

2 BUTANONE; ACETIC ACID ETHYL ESTER; CELLACEFATE; EUDRAGIT; LATEX; MEDISORB 100 D; MEDISORB 100 L; MOWIOL 4 88; NANOPARTICLE; POLOXAMER; POLYCAPROLACTONE; POLYLACTIC ACID; POLYVINYL ALCOHOL; SOLVENT; STABILIZING AGENT; TONE 767; UNCLASSIFIED DRUG; WATER;

AQUEOUS SOLUTION; ARTICLE; DIFFUSION; DISTILLATION; EMULSION; PARTICLE SIZE; POLYMERIZATION; PRIORITY JOURNAL; SOLUBILITY; TECHNIQUE;

CHEMISTRY, PHARMACEUTICAL; DIFFUSION; EMULSIONS; LATEX; MICROSCOPY, ELECTRON, SCANNING; PARTICLE SIZE; POLYMERS; SOLUBILITY; SOLVENTS; VOLATILIZATION;

EID: 0344980424     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00216-1     Document Type: Article

References (15)

1. Banker, G.S., 1982. Pharmaceutical coating composition, and preparation and dosages so coated. U.S. Pat. 4, 330, 338.
2. Banker G.S., Peck G.E. The new water-based colloidal dispersions. Pharm. Technol. 5(4):1981;55-62.
3. Bindschaedler C., Gurny R., Doelker E. Notions théoriques sur la formation des films obtenus à partir de microdispersions aqueuses et application à l'enrobage. Labo-Pharma-Probl. Tech. 31:1983;389-394.
4. Bodmeier R., McGinity J.W. Solvent selection in the preparation of poly(DL-lactide) microspheres prepared by the solvent evaporation method. Int. J. Pharm. 43:1988;179-186.
5. El-Aasser M.S., Vanderhoff J.W., Poehlein G.W. Preparation of polymer latexes with mixed emulsifier systems by emulsion polymerization and direct emulsification of polymer solutions. Coatings Plast. Preprint. 37:1977;92-97.
6. Hogan J. Film-coating materials and their properties. Cole G.C., Hogan J., Aulton M. Pharmaceutical Coating Technology. 1995;6-50 Taylor and Francis, London.
7. ICH, 1996. ICH Guideline for Residual Solvents Q3C, Step 2 Draft, 7 November 1996.
8. Koller C., Buri P. Propriétés et intérêt pharmaceutique des gels thermoréversibles à base de poloxamers et poloxamines. STP Pharma. 3:1987;115-124.
9. Opdyke D.L.J. Fragance raw materials monographs: ethyl acetate. Food Cosmet. Toxicol. 12:1974;711-712.
10. Quintanar-Guerrero D., Fessi H., Allémann E., Doelker E. Influence of stabilizing agents and preparative variables on the formation of Poly(D,L-lactic acid) nanoparticles by an emulsion-diffusion technique. Int. J. Pharm. 143:1996;133-141.
11. Quintanar-Guerrero D., Allémann E., Doelker E, Fessi H. Study of the formation mechanism of nanoparticles by the emulsion-diffusion technique. Colloid Polym. Sci. 275:1997;640-647.
12. Quintanar-Guerrero D., Allémann E., Fessi H., Doelker E. Influence of the stabilizer coating layer on the purification and freeze-drying of poly(D,L-lactic acid) nanoparticles prepared by an emulsification-diffusion technique. J. Microencapsul. 15:1998;107-119.
13. Vanderhoff, J.W., El-Aasser, M.S., Ugelstad, J., 1979. Polymer emulsification process. U.S. Pat. 4, 177, 177.
14. Wheatley T.A., Steuernagel C.R. Latex emulsions for controlled drug delivery. McGinity J.W. Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms. 1997;1-55 Marcel Dekker, New York.
15. Yamaoka T., Tabata Y., Ikada Y. Comparison of body distribution of poly(vinyl alcohol) with other water-soluble polymers after intravenous administration. J. Pharm. Pharmacol. 47:1995;479-486.